SNORA70C

Summary

SNORA70C (small nucleolar RNA, H/ACA box 70C, HGNC:33619) is a small nucleolar RNA gene on chromosome 9q33.1.

This gene produces a small nucleolar RNA (snoRNA) that plays a role in post-transcriptional modification. This snoRNA is a type-3 retrotransposed snoRNA, where the ribosomal protein L10 gene on chromosome X is its parental gene, and this, together with part of the parental gene, was subsequently mobilized into an intron of the astrotactin 2 host gene on chromosome 9. This snoRNA contains a H/ACA box, which serves as a guide for the pseudouridylation of selected bases of ribosomal RNA by forming short duplexes with the 18S rRNA U1692, the target for this snoRNA. This gene is specific to human, chimp and orangutan, and is not found in the genomes of rhesus or marmoset.

Source: NCBI Gene 100124538 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33619
Approved symbol	SNORA70C
Name	small nucleolar RNA, H/ACA box 70C
Location	9q33.1
Locus type	RNA, small nucleolar
Status	Approved
Ensembl gene	ENSG00000207268
Ensembl biotype	snoRNA
Entrez	100124538
RNAcentral	URS000075C3CE — snoRNA, 136 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000384538

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384538 — 1 exons

Exon	Start	End
ENSE00001807581	117181066	117181200

Expression profiles

Bgee: expression breadth broad, 26 present calls, max score 71.74.

Top tissues by expression

26 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
subcutaneous adipose tissue	UBERON:0002190	71.74	gold quality
intestine	UBERON:0000160	70.58	gold quality
stomach	UBERON:0000945	69.98	gold quality
popliteal artery	UBERON:0002250	68.73	gold quality
amygdala	UBERON:0001876	68.70	gold quality
minor salivary gland	UBERON:0001830	66.14	gold quality
substantia nigra	UBERON:0002038	66.05	gold quality
heart left ventricle	UBERON:0002084	65.68	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.01	gold quality
kidney	UBERON:0002113	62.66	gold quality
caudate nucleus	UBERON:0001873	62.62	gold quality
vagina	UBERON:0000996	62.07	gold quality
skin of abdomen	UBERON:0001416	61.59	gold quality
transverse colon	UBERON:0001157	60.68	gold quality
right atrium auricular region	UBERON:0006631	60.68	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.59	gold quality
right frontal lobe	UBERON:0002810	60.03	gold quality
cerebellar hemisphere	UBERON:0002245	59.84	gold quality
prostate gland	UBERON:0002367	59.59	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	59.57	gold quality
tibial nerve	UBERON:0001323	59.09	gold quality
nucleus accumbens	UBERON:0001882	58.69	gold quality
corpus callosum	UBERON:0002336	53.13	gold quality
pituitary gland	UBERON:0000007	50.44	gold quality
right testis	UBERON:0004534	45.08	gold quality
left testis	UBERON:0004533	42.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (35): SNORA70 (ENSG00000200237), SNORA70 (ENSG00000201376), SNORA70 (ENSG00000201945), SNORA70 (ENSG00000202379), SNORA70 (ENSG00000202389), SNORA70H (ENSG00000206637), SNORA70G (ENSG00000206650), SNORA70 (ENSG00000206661), SNORA70F (ENSG00000206869), SNORA70 (ENSG00000206886), SNORA70J (ENSG00000206909), SNORA70B (ENSG00000206937), SNORA70 (ENSG00000206958), SNORA70 (ENSG00000207098), SNORA70 (ENSG00000207165), SNORA70E (ENSG00000207221), SNORA70 (ENSG00000207244), SNORA70I (ENSG00000207274), SNORA70 (ENSG00000251796), SNORA70 (ENSG00000251893), SNORA70 (ENSG00000251925), SNORA70 (ENSG00000252014), SNORA70 (ENSG00000252133), SNORA70 (ENSG00000252199), SNORA70 (ENSG00000252258), SNORA70 (ENSG00000252505), SNORA70 (ENSG00000252526), SNORA70 (ENSG00000252657), SNORA70 (ENSG00000252724), SNORA70 (ENSG00000252969), SNORA70 (ENSG00000253027), SNORA70 (ENSG00000253042), SNORA70D (ENSG00000263666), SNORA70 (ENSG00000276094), SNORA70 (ENSG00000278010)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.