SNORA70E

Summary

SNORA70E (small nucleolar RNA, H/ACA box 70E, HGNC:34357) is a small nucleolar RNA gene on chromosome 11q14.1.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 100379250 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34357
Approved symbol	SNORA70E
Name	small nucleolar RNA, H/ACA box 70E
Location	11q14.1
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U70E
Ensembl gene	ENSG00000207221
Ensembl biotype	snoRNA
Entrez	100379250
RNAcentral	URS00006A2FF4 — snoRNA, 135 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000384492

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384492 — 1 exons

Exon	Start	End
ENSE00001807146	83041464	83041598

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 79.97.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
Brodmann (1909) area 9	UBERON:0013540	79.97	gold quality
blood	UBERON:0000178	74.23	gold quality
monocyte	CL:0000576	72.82	gold quality
adrenal tissue	UBERON:0018303	72.62	gold quality
bone marrow	UBERON:0002371	71.63	gold quality
islet of Langerhans	UBERON:0000006	71.45	gold quality
muscle of leg	UBERON:0001383	70.92	gold quality
adult mammalian kidney	UBERON:0000082	70.78	gold quality
lung	UBERON:0002048	70.78	gold quality
gastrocnemius	UBERON:0001388	70.76	gold quality
prefrontal cortex	UBERON:0000451	70.37	gold quality
liver	UBERON:0002107	69.70	gold quality
right lobe of liver	UBERON:0001114	68.67	gold quality
heart	UBERON:0000948	68.27	gold quality
endometrium	UBERON:0001295	67.82	gold quality
stomach	UBERON:0000945	67.32	gold quality
right lobe of thyroid gland	UBERON:0001119	66.33	gold quality
ectocervix	UBERON:0012249	66.00	gold quality
adrenal gland	UBERON:0002369	65.97	gold quality
ascending aorta	UBERON:0001496	65.82	gold quality
thoracic aorta	UBERON:0001515	65.54	gold quality
tibial artery	UBERON:0007610	65.49	gold quality
intestine	UBERON:0000160	65.00	gold quality
body of pancreas	UBERON:0001150	64.93	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.90	gold quality
right atrium auricular region	UBERON:0006631	64.87	gold quality
body of stomach	UBERON:0001161	64.66	gold quality
omental fat pad	UBERON:0010414	64.47	gold quality
skin of abdomen	UBERON:0001416	64.44	gold quality
kidney	UBERON:0002113	64.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.56

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP. (PMID:36056690)

Cross-species orthologs

0 orthologs

Paralogs (35): SNORA70 (ENSG00000200237), SNORA70 (ENSG00000201376), SNORA70 (ENSG00000201945), SNORA70 (ENSG00000202379), SNORA70 (ENSG00000202389), SNORA70H (ENSG00000206637), SNORA70G (ENSG00000206650), SNORA70 (ENSG00000206661), SNORA70F (ENSG00000206869), SNORA70 (ENSG00000206886), SNORA70J (ENSG00000206909), SNORA70B (ENSG00000206937), SNORA70 (ENSG00000206958), SNORA70 (ENSG00000207098), SNORA70 (ENSG00000207165), SNORA70 (ENSG00000207244), SNORA70C (ENSG00000207268), SNORA70I (ENSG00000207274), SNORA70 (ENSG00000251796), SNORA70 (ENSG00000251893), SNORA70 (ENSG00000251925), SNORA70 (ENSG00000252014), SNORA70 (ENSG00000252133), SNORA70 (ENSG00000252199), SNORA70 (ENSG00000252258), SNORA70 (ENSG00000252505), SNORA70 (ENSG00000252526), SNORA70 (ENSG00000252657), SNORA70 (ENSG00000252724), SNORA70 (ENSG00000252969), SNORA70 (ENSG00000253027), SNORA70 (ENSG00000253042), SNORA70D (ENSG00000263666), SNORA70 (ENSG00000276094), SNORA70 (ENSG00000278010)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.