SNORA74B

Summary

SNORA74B (small nucleolar RNA, H/ACA box 74B, HGNC:32660) is a small nucleolar RNA gene on chromosome 5q35.1.

Small nucleolar RNAs (snoRNAs) are small noncoding RNAs involved in RNA processing. Box H/ACA snoRNAs, such as SNORA74B, direct the conversion of uridine to pseudouridine at specific residues of ribosomal RNAs or small nuclear RNAs (snRNAs) (Gu et al., 2005).

Source: NCBI Gene 677841 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32660
Approved symbol	SNORA74B
Name	small nucleolar RNA, H/ACA box 74B
Location	5q35.1
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U19-2
Ensembl gene	ENSG00000212402
Ensembl biotype	snoRNA
OMIM	611331
Entrez	677841
RNAcentral	URS000000D517 — lncRNA, 204 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000391100

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000391100 — 1 exons

Exon	Start	End
ENSE00001809258	173020728	173020928

Expression profiles

Bgee: expression breadth ubiquitous, 120 present calls, max score 99.76.

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	99.76	gold quality
adrenal tissue	UBERON:0018303	99.18	gold quality
sural nerve	UBERON:0015488	99.15	gold quality
corpus callosum	UBERON:0002336	96.82	gold quality
bone marrow cell	CL:0002092	94.67	gold quality
colonic epithelium	UBERON:0000397	93.01	gold quality
bone marrow	UBERON:0002371	91.99	gold quality
skeletal muscle tissue	UBERON:0001134	90.37	gold quality
tonsil	UBERON:0002372	82.79	gold quality
cortical plate	UBERON:0005343	82.32	gold quality
liver	UBERON:0002107	78.89	gold quality
prefrontal cortex	UBERON:0000451	78.42	gold quality
urinary bladder	UBERON:0001255	78.37	gold quality
hindlimb stylopod muscle	UBERON:0004252	76.37	gold quality
kidney	UBERON:0002113	76.13	gold quality
blood	UBERON:0000178	75.80	gold quality
monocyte	CL:0000576	74.08	gold quality
calcaneal tendon	UBERON:0003701	72.14	gold quality
cortex of kidney	UBERON:0001225	71.09	gold quality
lung	UBERON:0002048	70.29	gold quality
primary visual cortex	UBERON:0002436	69.84	gold quality
stomach	UBERON:0000945	69.24	gold quality
islet of Langerhans	UBERON:0000006	68.56	gold quality
adult mammalian kidney	UBERON:0000082	67.14	gold quality
lymph node	UBERON:0000029	66.49	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	66.25	gold quality
adrenal gland	UBERON:0002369	65.56	gold quality
muscle of leg	UBERON:0001383	65.33	gold quality
pancreas	UBERON:0001264	64.79	gold quality
heart	UBERON:0000948	64.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.74

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• High SNORA74B expression is associated with gallbladder cancer. (PMID:28212545)

Cross-species orthologs

0 orthologs

Paralogs (8): SNORA74A (ENSG00000200959), SNORA74 (ENSG00000252129), SNORA74D (ENSG00000252213), SNORA74 (ENSG00000252305), SNORA74 (ENSG00000252917), SNORA74C-1 (ENSG00000265733), SNORA74 (ENSG00000272025), SNORA74C-2 (ENSG00000288603)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.