SNORA74D

Summary

SNORA74D (small nucleolar RNA, H/ACA box 74D, HGNC:52219) is a small nucleolar RNA gene on chromosome 5q31.2.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52219
Approved symbol	SNORA74D
Name	small nucleolar RNA, H/ACA box 74D
Location	5q31.2
Locus type	RNA, small nucleolar
Status	Approved
Ensembl gene	ENSG00000252213
Ensembl biotype	snoRNA
Entrez	109616975
RNAcentral	URS0000ABD80F — snoRNA, 144 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000516404

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000516404 — 1 exons

Exon	Start	End
ENSE00002088681	139276180	139276320

Expression profiles

Bgee: expression breadth broad, 91 present calls, max score 99.33.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6795 / max 54.2742, expressed in 291 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
58809	0.6795	291

Top tissues by expression

91 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.33	gold quality
adrenal tissue	UBERON:0018303	96.67	gold quality
liver	UBERON:0002107	91.28	gold quality
kidney	UBERON:0002113	83.54	gold quality
lung	UBERON:0002048	78.30	gold quality
stomach	UBERON:0000945	77.55	gold quality
adult mammalian kidney	UBERON:0000082	77.37	gold quality
blood	UBERON:0000178	76.28	gold quality
skeletal muscle tissue	UBERON:0001134	76.15	gold quality
left coronary artery	UBERON:0001626	74.45	gold quality
calcaneal tendon	UBERON:0003701	74.19	gold quality
prefrontal cortex	UBERON:0000451	73.39	gold quality
corpus callosum	UBERON:0002336	72.96	gold quality
islet of Langerhans	UBERON:0000006	72.80	gold quality
heart	UBERON:0000948	72.75	gold quality
adrenal gland	UBERON:0002369	71.70	gold quality
left uterine tube	UBERON:0001303	71.52	gold quality
muscle of leg	UBERON:0001383	70.88	gold quality
vermiform appendix	UBERON:0001154	70.82	gold quality
ectocervix	UBERON:0012249	70.24	gold quality
gastrocnemius	UBERON:0001388	70.02	gold quality
right lobe of liver	UBERON:0001114	68.84	gold quality
heart left ventricle	UBERON:0002084	68.15	gold quality
body of pancreas	UBERON:0001150	68.08	gold quality
lymph node	UBERON:0000029	67.78	gold quality
body of stomach	UBERON:0001161	67.13	gold quality
tibial artery	UBERON:0007610	67.07	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.76	gold quality
Ammon’s horn	UBERON:0001954	66.60	gold quality
intestine	UBERON:0000160	66.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.77

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	SNORA74	ENSDARG00000082930
danio_rerio	SNORA74	ENSDARG00000102120
mus_musculus	Gm54507	ENSMUSG00002076696

Paralogs (8): SNORA74A (ENSG00000200959), SNORA74B (ENSG00000212402), SNORA74 (ENSG00000252129), SNORA74 (ENSG00000252305), SNORA74 (ENSG00000252917), SNORA74C-1 (ENSG00000265733), SNORA74 (ENSG00000272025), SNORA74C-2 (ENSG00000288603)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.