SNORA80E

Summary

SNORA80E (small nucleolar RNA, H/ACA box 80E, HGNC:32635) is a small nucleolar RNA gene on chromosome 1q22.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 677823 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32635
Approved symbol	SNORA80E
Name	small nucleolar RNA, H/ACA box 80E
Location	1q22
Locus type	RNA, small nucleolar
Status	Approved
Aliases	ACA42
Ensembl gene	ENSG00000207475
Ensembl biotype	snoRNA
Entrez	677823
RNAcentral	URS00003D5684 — snoRNA, 134 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000384744

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384744 — 1 exons

Exon	Start	End
ENSE00001499752	155919909	155920045

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 99.82.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4080 / max 54.2742, expressed in 202 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14998	0.4080	202

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.82	gold quality
adrenal tissue	UBERON:0018303	94.01	gold quality
liver	UBERON:0002107	81.26	gold quality
kidney	UBERON:0002113	79.64	gold quality
superior frontal gyrus	UBERON:0002661	78.51	gold quality
adult mammalian kidney	UBERON:0000082	78.43	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	78.01	gold quality
monocyte	CL:0000576	77.65	gold quality
skeletal muscle tissue	UBERON:0001134	76.57	gold quality
bone marrow	UBERON:0002371	76.17	gold quality
endometrium	UBERON:0001295	75.80	gold quality
blood	UBERON:0000178	75.61	gold quality
stomach	UBERON:0000945	75.07	gold quality
endocervix	UBERON:0000458	73.96	gold quality
islet of Langerhans	UBERON:0000006	73.74	gold quality
calcaneal tendon	UBERON:0003701	73.59	gold quality
ectocervix	UBERON:0012249	73.35	gold quality
fundus of stomach	UBERON:0001160	72.50	gold quality
lung	UBERON:0002048	72.43	gold quality
body of stomach	UBERON:0001161	72.22	gold quality
right coronary artery	UBERON:0001625	72.18	gold quality
muscle of leg	UBERON:0001383	71.96	gold quality
vermiform appendix	UBERON:0001154	71.75	gold quality
duodenum	UBERON:0002114	71.67	gold quality
body of pancreas	UBERON:0001150	71.59	gold quality
gastrocnemius	UBERON:0001388	71.41	gold quality
right ovary	UBERON:0002118	70.46	gold quality
fallopian tube	UBERON:0003889	70.23	gold quality
left uterine tube	UBERON:0001303	70.09	gold quality
adrenal gland	UBERON:0002369	70.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.97

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• High Small nucleolar RNA 42 is associated with lung tumorigenesis. (PMID:21986946)
• SNORA42 expression negatively correlated with overall survival in an additional independent cohort and identified the patients with high risk for recurrence and poor prognosis in stage II CRC. Furthermore, in vitro and in vivo analyses showed that SNORA42 overexpression resulted in enhanced cell proliferation, migration, invasion, anoikis resistance and tumorigenicity. (PMID:26475630)
• SNORA42 enhances prostate cancer cell viability, migration and EMT and is correlated with prostate cancer poor prognosis (PMID:30053504)
• SNORA42 promotes oesophageal squamous cell carcinoma development through triggering the DHX9/p65 axis. (PMID:34182081)
• What is the Role of SNORA42 in Carcinogenesis? A Systematic Review. (PMID:37505750)

Cross-species orthologs

0 orthologs

Paralogs (6): SNORA80C (ENSG00000199787), (ENSG00000200385), SNORA80A (ENSG00000200792), SNORA80B (ENSG00000206633), SNORA80D (ENSG00000207217), (ENSG00000207502)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.