SNORA81

Summary

SNORA81 (small nucleolar RNA, H/ACA box 81, HGNC:32667) is a small nucleolar RNA gene on chromosome 3q27.3.

Small nucleolar RNAs (snoRNAs) are small noncoding RNAs involved in RNA processing. Box H/ACA snoRNAs, such as SNORA81, direct the conversion of uridine to pseudouridine at specific residues of ribosomal RNAs or small nuclear RNAs (snRNAs) (Gu et al., 2005).

Source: NCBI Gene 677847 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32667
Approved symbol	SNORA81
Name	small nucleolar RNA, H/ACA box 81
Location	3q27.3
Locus type	RNA, small nucleolar
Status	Approved
Aliases	HBI-61
Ensembl gene	ENSG00000221420
Ensembl biotype	snoRNA
OMIM	611334
Entrez	677847
RNAcentral	URS00025E358E — snoRNA, 177 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000408493

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408493 — 1 exons

Exon	Start	End
ENSE00001565128	186786675	186786852

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 99.89.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2630 / max 37.7609, expressed in 96 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
40310	0.2630	96

Top tissues by expression

23 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.89	gold quality
adrenal tissue	UBERON:0018303	99.82	gold quality
lung	UBERON:0002048	99.71	gold quality
kidney	UBERON:0002113	99.71	gold quality
adult mammalian kidney	UBERON:0000082	99.54	gold quality
heart	UBERON:0000948	99.47	gold quality
stomach	UBERON:0000945	97.48	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	96.62	gold quality
intestine	UBERON:0000160	96.62	gold quality
liver	UBERON:0002107	93.22	gold quality
colon	UBERON:0001155	92.33	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	88.65	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.59	gold quality
calcaneal tendon	UBERON:0003701	76.11	gold quality
prefrontal cortex	UBERON:0000451	74.76	gold quality
blood	UBERON:0000178	72.65	gold quality
anterior cingulate cortex	UBERON:0009835	72.20	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.25	gold quality
brain	UBERON:0000955	71.10	gold quality
muscle of leg	UBERON:0001383	68.43	gold quality
nucleus accumbens	UBERON:0001882	68.38	gold quality
gastrocnemius	UBERON:0001388	65.02	gold quality
islet of Langerhans	UBERON:0000006	62.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Snora81	ENSMUSG00000087935
mus_musculus	Gm22519	ENSMUSG00000088895
rattus_norvegicus	Snora81	ENSRNOG00000060539

Paralogs (3): (ENSG00000238390), (ENSG00000252677), (ENSG00000253092)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.