SNORD105

Summary

SNORD105 (small nucleolar RNA, C/D box 105, HGNC:32769) is a small nucleolar RNA gene on chromosome 19p13.2.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 692229 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32769
Approved symbol	SNORD105
Name	small nucleolar RNA, C/D box 105
Location	19p13.2
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U105
Ensembl gene	ENSG00000209645
Ensembl biotype	snoRNA
Entrez	692229
RNAcentral	URS0000467AB5 — snoRNA, 85 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000386910

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000386910 — 1 exons

Exon	Start	End
ENSE00001501916	10107651	10107735

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 98.62.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0302 / max 15.7873, expressed in 6 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173735	0.0302	6

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.62	gold quality
adrenal tissue	UBERON:0018303	83.77	gold quality
duodenum	UBERON:0002114	81.60	gold quality
bone marrow	UBERON:0002371	79.30	gold quality
liver	UBERON:0002107	77.04	gold quality
blood	UBERON:0000178	76.13	gold quality
islet of Langerhans	UBERON:0000006	75.80	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.90	gold quality
kidney	UBERON:0002113	74.41	gold quality
muscle of leg	UBERON:0001383	74.30	gold quality
monocyte	CL:0000576	73.44	gold quality
gastrocnemius	UBERON:0001388	73.00	gold quality
heart left ventricle	UBERON:0002084	72.61	gold quality
endometrium	UBERON:0001295	72.33	gold quality
heart	UBERON:0000948	72.31	gold quality
lower esophagus mucosa	UBERON:0035834	70.98	gold quality
right atrium auricular region	UBERON:0006631	70.11	gold quality
stomach	UBERON:0000945	69.78	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.46	gold quality
body of stomach	UBERON:0001161	68.99	gold quality
lung	UBERON:0002048	68.85	gold quality
body of pancreas	UBERON:0001150	68.63	gold quality
granulocyte	CL:0000094	68.61	gold quality
left adrenal gland cortex	UBERON:0035825	68.13	gold quality
myometrium	UBERON:0001296	67.89	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.89	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.89	gold quality
right adrenal gland	UBERON:0001233	67.53	gold quality
omental fat pad	UBERON:0010414	67.26	gold quality
transverse colon	UBERON:0001157	67.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• An SNP reducing SNORD105 and PPAN expression decreases the risk of hepatocellular carcinoma in a Chinese population. (PMID:34741342)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm24067	ENSMUSG00000077702
rattus_norvegicus	Snord105	ENSRNOG00000060532

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.