SNORD105B

Summary

SNORD105B (small nucleolar RNA, C/D box 105B, HGNC:33572) is a small nucleolar RNA gene on chromosome 19q13.2.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 100113382 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33572
Approved symbol	SNORD105B
Name	small nucleolar RNA, C/D box 105B
Location	19q13.2
Locus type	RNA, small nucleolar
Status	Approved
Ensembl gene	ENSG00000238531
Ensembl biotype	snoRNA
Entrez	100113382
RNAcentral	URS000075DF1C — snoRNA, 92 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000458770

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000458770 — 1 exons

Exon	Start	End
ENSE00001808211	10109757	10109835

Expression profiles

Bgee: expression breadth broad, 80 present calls, max score 99.74.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3557 / max 108.5483, expressed in 143 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173736	0.3557	143

Top tissues by expression

80 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.74	gold quality
adrenal tissue	UBERON:0018303	86.10	gold quality
liver	UBERON:0002107	82.13	gold quality
calcaneal tendon	UBERON:0003701	81.31	gold quality
vermiform appendix	UBERON:0001154	81.10	gold quality
blood	UBERON:0000178	81.00	gold quality
bone marrow	UBERON:0002371	79.72	gold quality
Brodmann (1909) area 9	UBERON:0013540	79.12	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	76.76	gold quality
monocyte	CL:0000576	74.07	gold quality
stomach	UBERON:0000945	73.44	gold quality
lung	UBERON:0002048	73.08	gold quality
heart	UBERON:0000948	72.05	gold quality
kidney	UBERON:0002113	70.24	gold quality
heart left ventricle	UBERON:0002084	69.66	gold quality
islet of Langerhans	UBERON:0000006	69.33	gold quality
prefrontal cortex	UBERON:0000451	69.14	gold quality
right lobe of liver	UBERON:0001114	69.12	gold quality
endometrium	UBERON:0001295	68.97	gold quality
body of pancreas	UBERON:0001150	68.95	gold quality
gastrocnemius	UBERON:0001388	68.79	gold quality
tibial nerve	UBERON:0001323	68.13	gold quality
endocervix	UBERON:0000458	67.98	gold quality
right atrium auricular region	UBERON:0006631	67.76	gold quality
amygdala	UBERON:0001876	67.53	gold quality
body of stomach	UBERON:0001161	67.36	gold quality
intestine	UBERON:0000160	67.08	gold quality
colon	UBERON:0001155	67.03	gold quality
tibial artery	UBERON:0007610	66.30	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Snord105b appears to be a novel oncogene and is clinically and functionally involved in the development of Gastric Cancer. (PMID:29554660)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm23008	ENSMUSG00000089571
rattus_norvegicus	Snord105b	ENSRNOG00000055949

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.