SNORD113-1

Summary

SNORD113-1 (small nucleolar RNA, C/D box 113-1, HGNC:32980) is a small nucleolar RNA gene on chromosome 14q32.31.

Small nucleolar RNAs (snoRNAs), like SNORD113-1, guide the formation of 2-prime O-methylation of ribosomal RNA (rRNA) and U small nuclear RNAs (snRNAs) through a specific RNA duplex at each modification site. SNORD113-1 is 1 of 9 tandem SNORD113 genes on chromosome 14q32 (Cavaille et al., 2002 [PubMed 12045206]).

Source: NCBI Gene 767561 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32980
Approved symbol	SNORD113-1
Name	small nucleolar RNA, C/D box 113-1
Location	14q32.31
Locus type	RNA, small nucleolar
Status	Approved
Aliases	14q(I-1)
Ensembl gene	ENSG00000202191
Ensembl biotype	snoRNA
OMIM	613650
Entrez	767561
RNAcentral	URS0000AA385E — snoRNA, 69 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000365321

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000365321 — 1 exons

Exon	Start	End
ENSE00001440084	100924824	100924892

Expression profiles

Bgee: expression breadth broad, 85 present calls, max score 99.56.

Top tissues by expression

85 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	99.56	gold quality
kidney	UBERON:0002113	92.76	gold quality
calcaneal tendon	UBERON:0003701	86.85	gold quality
lung	UBERON:0002048	84.34	gold quality
stomach	UBERON:0000945	84.00	gold quality
prefrontal cortex	UBERON:0000451	83.05	gold quality
placenta	UBERON:0001987	80.98	gold quality
adult mammalian kidney	UBERON:0000082	80.02	gold quality
liver	UBERON:0002107	79.28	gold quality
corpus callosum	UBERON:0002336	76.16	gold quality
adrenal gland	UBERON:0002369	75.64	gold quality
endometrium	UBERON:0001295	75.56	gold quality
right adrenal gland cortex	UBERON:0035827	75.11	gold quality
heart	UBERON:0000948	74.72	gold quality
right adrenal gland	UBERON:0001233	74.57	gold quality
gastrocnemius	UBERON:0001388	74.09	gold quality
right lobe of liver	UBERON:0001114	73.88	gold quality
right ovary	UBERON:0002118	73.63	gold quality
left ovary	UBERON:0002119	73.18	gold quality
ovary	UBERON:0000992	73.17	gold quality
intestine	UBERON:0000160	73.03	gold quality
left adrenal gland cortex	UBERON:0035825	72.78	gold quality
body of pancreas	UBERON:0001150	72.68	gold quality
blood	UBERON:0000178	72.61	gold quality
left adrenal gland	UBERON:0001234	71.63	gold quality
gall bladder	UBERON:0002110	71.51	gold quality
adenohypophysis	UBERON:0002196	71.36	gold quality
islet of Langerhans	UBERON:0000006	70.15	gold quality
pituitary gland	UBERON:0000007	70.10	gold quality
colon	UBERON:0001155	69.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Results show that SNORD113-1 functions as a tumor suppressor role in hepatocellular carcinoma. (PMID:25217841)

Cross-species orthologs

0 orthologs

Paralogs (44): SNORD114-7 (ENSG00000199390), SNORD114-1 (ENSG00000199575), SNORD114-14 (ENSG00000199593), SNORD114-5 (ENSG00000199798), SNORD114-16 (ENSG00000199914), SNORD114-19 (ENSG00000199942), SNORD114-31 (ENSG00000200089), (ENSG00000200150), SNORD113-6 (ENSG00000200215), SNORD114-10 (ENSG00000200279), SNORD113-8 (ENSG00000200367), SNORD114-23 (ENSG00000200406), SNORD114-26 (ENSG00000200413), SNORD114-28 (ENSG00000200480), SNORD114-11 (ENSG00000200608), SNORD114-25 (ENSG00000200612), SNORD113-7 (ENSG00000200632), SNORD114-27 (ENSG00000200636), SNORD114-2 (ENSG00000200823), SNORD114-4 (ENSG00000200832), (ENSG00000201036), SNORD114-9 (ENSG00000201240), SNORD114-13 (ENSG00000201247), SNORD114-6 (ENSG00000201263), SNORD114-30 (ENSG00000201318), (ENSG00000201500), SNORD114-15 (ENSG00000201557), SNORD114-17 (ENSG00000201569), SNORD113-4 (ENSG00000201672), SNORD114-29 (ENSG00000201689), SNORD113-3 (ENSG00000201700), (ENSG00000201710), SNORD114-3 (ENSG00000201839), SNORD114-24 (ENSG00000201899), SNORD113-9 (ENSG00000201950), SNORD114-20 (ENSG00000202048), SNORD114-18 (ENSG00000202142), SNORD114-12 (ENSG00000202270), SNORD114-22 (ENSG00000202293), SNORD113-2 (ENSG00000212384)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.