SNORD115-1

Summary

SNORD115-1 (small nucleolar RNA, C/D box 115-1, HGNC:33020) is a small nucleolar RNA gene on chromosome 15q11.2.

This gene encodes a small nucleolar RNA (snoRNA) that is found clustered with dozens of other similar snoRNAs on chromosome 15. These genes are found mostly within introns of the IC-SNURF-SNRPN transcript, which is paternally imprinted and from the Prader-Willi/Angelman syndrome (PWS) region. This gene has been designated as copy 1 of the cluster and may be involved in the regulation of RNA editing and/or alternative splicing of the serotonin receptor 2C (HTR2C) transcript. This gene is not thought to play a major role in PWS.

Source: NCBI Gene 338433 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33020
Approved symbol	SNORD115-1
Name	small nucleolar RNA, C/D box 115-1
Location	15q11.2
Locus type	RNA, small nucleolar
Status	Approved
Aliases	HBII-52-1
Ensembl gene	ENSG00000201831
Ensembl biotype	snoRNA
OMIM	609837
Entrez	338433
RNAcentral	URS00006E53B3 — snoRNA, 82 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000364961

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000364961 — 1 exons

Exon	Start	End
ENSE00001807317	25170723	25170804

Expression profiles

Bgee: expression breadth broad, 34 present calls, max score 86.18.

Top tissues by expression

34 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	86.18	gold quality
Brodmann (1909) area 9	UBERON:0013540	79.20	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	75.49	gold quality
gastrocnemius	UBERON:0001388	69.73	gold quality
prefrontal cortex	UBERON:0000451	69.58	gold quality
blood	UBERON:0000178	68.70	gold quality
ascending aorta	UBERON:0001496	68.39	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.89	gold quality
left coronary artery	UBERON:0001626	67.26	gold quality
right frontal lobe	UBERON:0002810	66.59	gold quality
adult mammalian kidney	UBERON:0000082	65.76	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.67	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.37	gold quality
adrenal tissue	UBERON:0018303	63.96	gold quality
caudate nucleus	UBERON:0001873	63.54	gold quality
cerebellar hemisphere	UBERON:0002245	63.36	gold quality
anterior cingulate cortex	UBERON:0009835	63.27	gold quality
skin of leg	UBERON:0001511	62.31	gold quality
Ammon’s horn	UBERON:0001954	62.10	gold quality
heart left ventricle	UBERON:0002084	61.90	gold quality
lung	UBERON:0002048	61.06	gold quality
hypothalamus	UBERON:0001898	60.50	gold quality
putamen	UBERON:0001874	59.66	gold quality
heart	UBERON:0000948	59.22	gold quality
tibial nerve	UBERON:0001323	57.62	gold quality
esophagus mucosa	UBERON:0002469	54.94	gold quality
islet of Langerhans	UBERON:0000006	54.43	gold quality
left lobe of thyroid gland	UBERON:0001120	52.36	gold quality
right atrium auricular region	UBERON:0006631	51.45	gold quality
pituitary gland	UBERON:0000007	51.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• SNORD115-1 gene is imprinted, with preferential expression from the paternal allele in the brain. (PMID:11106375)
• Since the complete loss of the HBII-52 genes in family members who carry the deletion on their paternal chromosome is not associated with an obvious clinical phenotype, we conclude that HBII-52 snoRNA genes do not play a major role in PWS. (PMID:15565282)
• results show that a snoRNA regulates the processing of an mRNA expressed from a gene located on a different chromosome, and the results indicate that a defect in pre-mRNA processing contributes to the Prader-Willi syndrome (PMID:16357227)
• The likely evolutionary history of the HBII-52 cluster and SNORD119 and suggest that they have evolved from a common ancestor, is constructed. (PMID:18616950)

Cross-species orthologs

0 orthologs

Paralogs (49): SNORD115-34 (ENSG00000199311), SNORD115-12 (ENSG00000199453), SNORD115-25 (ENSG00000199489), SNORD115-29 (ENSG00000199704), SNORD115-2 (ENSG00000199712), SNORD115-9 (ENSG00000199782), SNORD115-21 (ENSG00000199833), SNORD115-14 (ENSG00000199960), SNORD115-19 (ENSG00000199968), SNORD115-3 (ENSG00000199970), SNORD115-18 (ENSG00000200163), SNORD115-24 (ENSG00000200398), SNORD115-41 (ENSG00000200478), SNORD115-11 (ENSG00000200486), SNORD115-5 (ENSG00000200503), SNORD115-39 (ENSG00000200564), SNORD115-33 (ENSG00000200593), SNORD115-37 (ENSG00000200638), SNORD115-4 (ENSG00000200680), SNORD115-8 (ENSG00000200726), SNORD115-16 (ENSG00000200757), SNORD115-28 (ENSG00000200801), SNORD115-6 (ENSG00000200812), SNORD115-32 (ENSG00000200949), SNORD115-30 (ENSG00000200987), SNORD115-42 (ENSG00000201143), SNORD115-27 (ENSG00000201300), SNORD115-22 (ENSG00000201326), SNORD115-23 (ENSG00000201331), SNORD115-17 (ENSG00000201482), SNORD115-48 (ENSG00000201634), SNORD115-15 (ENSG00000201679), SNORD115-38 (ENSG00000201907), SNORD115-10 (ENSG00000201943), SNORD115-20 (ENSG00000201969), SNORD115-35 (ENSG00000201992), SNORD115-31 (ENSG00000202188), SNORD115-44 (ENSG00000202261), SNORD115-43 (ENSG00000202373), SNORD115-36 (ENSG00000202499)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.