SNORD116-1

Summary

SNORD116-1 (small nucleolar RNA, C/D box 116-1, HGNC:33067) is a small nucleolar RNA gene on chromosome 15q11.2.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 100033413 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33067
Approved symbol	SNORD116-1
Name	small nucleolar RNA, C/D box 116-1
Location	15q11.2
Locus type	RNA, small nucleolar
Status	Approved
Aliases	HBII-85-1
Ensembl gene	ENSG00000207063
Ensembl biotype	snoRNA
OMIM	605436
Entrez	100033413
RNAcentral	URS000075CFA5 — snoRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000384335

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384335 — 1 exons

Exon	Start	End
ENSE00001807735	25051477	25051571

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 98.91.

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.91	gold quality
adrenal tissue	UBERON:0018303	91.76	gold quality
kidney	UBERON:0002113	90.86	gold quality
liver	UBERON:0002107	88.89	gold quality
adrenal gland	UBERON:0002369	86.91	gold quality
lung	UBERON:0002048	85.74	gold quality
adult mammalian kidney	UBERON:0000082	84.92	gold quality
blood	UBERON:0000178	84.74	gold quality
stomach	UBERON:0000945	84.65	gold quality
intestine	UBERON:0000160	83.76	gold quality
heart	UBERON:0000948	80.07	gold quality
tibial nerve	UBERON:0001323	79.59	gold quality
vermiform appendix	UBERON:0001154	77.33	gold quality
Brodmann (1909) area 9	UBERON:0013540	76.17	gold quality
endometrium	UBERON:0001295	76.04	gold quality
calcaneal tendon	UBERON:0003701	75.12	gold quality
colon	UBERON:0001155	75.08	gold quality
islet of Langerhans	UBERON:0000006	73.61	gold quality
muscle of leg	UBERON:0001383	72.62	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.02	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.70	gold quality
body of stomach	UBERON:0001161	70.27	gold quality
gastrocnemius	UBERON:0001388	70.08	gold quality
left adrenal gland	UBERON:0001234	69.13	gold quality
vagina	UBERON:0000996	67.73	gold quality
heart left ventricle	UBERON:0002084	67.08	gold quality
Ammon’s horn	UBERON:0001954	66.06	gold quality
tibial artery	UBERON:0007610	65.45	gold quality
right atrium auricular region	UBERON:0006631	64.83	gold quality
body of uterus	UBERON:0009853	64.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• study indicates that paternally expressed Snord116 is involved in the 24-h regulation of sleep physiological measures, suggesting that it is a candidate gene for the sleep disturbances that most individuals with Prader-Willi syndrome experience (PMID:26446116)
• These results further support an overlapping critical deletion region involving the non-coding snoRNA SNORD116 in common in the five individuals playing a key role in contributing to the Prader-Willi syndrome phenotype (PMID:27659713)
• The presence of macrocephaly, observed in other cases of SNORD116 deletions as well, is uncommon for the classic phenotype of the syndrome (PMID:28266014)
• Loss of Snord116 alters cortical neuronal activity in mice: a preclinical investigation of Prader-Willi syndrome. (PMID:32426821)
• What can we learn from PWS and SNORD116 genes about the pathophysiology of addictive disorders? (PMID:33082508)
• SNORD116 and growth hormone therapy impact IGFBP7 in Prader-Willi syndrome. (PMID:34040195)

Cross-species orthologs

0 orthologs

Paralogs (32): SNORD116-10 (ENSG00000200661), SNORD116 (ENSG00000202498), SNORD116-11 (ENSG00000206609), SNORD116-14 (ENSG00000206621), SNORD116-17 (ENSG00000206656), SNORD116-18 (ENSG00000206688), SNORD116-9 (ENSG00000206727), SNORD116-2 (ENSG00000207001), SNORD116-3 (ENSG00000207014), SNORD116-8 (ENSG00000207093), SNORD116-7 (ENSG00000207133), SNORD116-13 (ENSG00000207137), SNORD116-15 (ENSG00000207174), SNORD116-5 (ENSG00000207191), SNORD116-12 (ENSG00000207197), SNORD116-29 (ENSG00000207245), SNORD116-16 (ENSG00000207263), SNORD116-24 (ENSG00000207279), SNORD116-23 (ENSG00000207375), SNORD116-6 (ENSG00000207442), SNORD116-19 (ENSG00000207460), SNORD116 (ENSG00000212553), SNORD116-26 (ENSG00000251815), SNORD116-27 (ENSG00000251896), SNORD116-30 (ENSG00000252277), SNORD116-25 (ENSG00000252326), SNORD116 (ENSG00000252985), SNORD116-22 (ENSG00000275127), SNORD116-4 (ENSG00000275529), SNORD116-21 (ENSG00000277785), SNORD116-28 (ENSG00000278123), SNORD116-20 (ENSG00000278715)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.