SNORD12B

Summary

SNORD12B (small nucleolar RNA, C/D box 12B, HGNC:33573) is a small nucleolar RNA gene on chromosome 20q13.13.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 100113393 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33573
Approved symbol	SNORD12B
Name	small nucleolar RNA, C/D box 12B
Location	20q13.13
Locus type	RNA, small nucleolar
Status	Approved
Ensembl gene	ENSG00000222365
Ensembl biotype	snoRNA
Entrez	100113393
RNAcentral	URS000075BC17 — snoRNA, 103 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000410433

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000410433 — 1 exons

Exon	Start	End
ENSE00001590251	49280319	49280409

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 96.96.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2829 / max 27.2690, expressed in 118 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
185161	0.2829	118

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.96	gold quality
bone marrow	UBERON:0002371	87.83	gold quality
blood	UBERON:0000178	86.69	gold quality
endometrium	UBERON:0001295	85.21	gold quality
rectum	UBERON:0001052	84.27	gold quality
adrenal tissue	UBERON:0018303	84.18	gold quality
vermiform appendix	UBERON:0001154	83.34	gold quality
granulocyte	CL:0000094	83.11	gold quality
monocyte	CL:0000576	83.09	gold quality
duodenum	UBERON:0002114	82.75	gold quality
smooth muscle tissue	UBERON:0001135	82.07	gold quality
calcaneal tendon	UBERON:0003701	81.13	gold quality
kidney	UBERON:0002113	80.87	gold quality
skin of abdomen	UBERON:0001416	80.53	gold quality
lung	UBERON:0002048	79.83	gold quality
corpus callosum	UBERON:0002336	79.77	gold quality
zone of skin	UBERON:0000014	79.43	gold quality
right lung	UBERON:0002167	79.27	gold quality
liver	UBERON:0002107	79.09	gold quality
skin of leg	UBERON:0001511	78.67	gold quality
adult mammalian kidney	UBERON:0000082	78.10	gold quality
upper lobe of left lung	UBERON:0008952	77.40	gold quality
stomach	UBERON:0000945	77.36	gold quality
saliva-secreting gland	UBERON:0001044	77.12	gold quality
right ovary	UBERON:0002118	76.98	gold quality
vagina	UBERON:0000996	76.89	gold quality
esophagus mucosa	UBERON:0002469	76.82	gold quality
minor salivary gland	UBERON:0001830	76.52	gold quality
ovary	UBERON:0000992	75.36	gold quality
gastrocnemius	UBERON:0001388	75.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.91

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Oncogenic SNORD12B activates the AKT-mTOR-4EBP1 signaling in esophageal squamous cell carcinoma via nucleus partitioning of PP-1alpha. (PMID:33941854)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm23201	ENSMUSG00000077565
rattus_norvegicus	Gm23201	ENSRNOG00000060842

Paralogs (2): SNORD12C (ENSG00000209042), SNORD12 (ENSG00000212304)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.