SNORD138

Summary

SNORD138 (small nucleolar RNA, C/D box 138, HGNC:50420) is a microRNA gene on chromosome 5q14.3.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 109623460 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50420
Approved symbol	SNORD138
Name	small nucleolar RNA, C/D box 138
Location	5q14.3
Locus type	RNA, small nucleolar
Status	Approved
Aliases	hsa-mir-3607
Ensembl gene	ENSG00000284078
Ensembl biotype	miRNA
Entrez	109623460
RNAcentral	URS000062539F — snoRNA, 63 nt, 9 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637229

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637229 — 1 exons

Exon	Start	End
ENSE00003800632	86620497	86620575

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 93.29.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.29	gold quality
liver	UBERON:0002107	82.45	gold quality
Brodmann (1909) area 9	UBERON:0013540	77.45	gold quality
tibial artery	UBERON:0007610	74.26	gold quality
stomach	UBERON:0000945	68.93	gold quality
muscle of leg	UBERON:0001383	68.86	gold quality
body of stomach	UBERON:0001161	68.80	gold quality
blood	UBERON:0000178	65.19	gold quality
hypothalamus	UBERON:0001898	64.68	gold quality
gastrocnemius	UBERON:0001388	64.29	gold quality
urinary bladder	UBERON:0001255	60.55	gold quality
subcutaneous adipose tissue	UBERON:0002190	57.35	gold quality
omental fat pad	UBERON:0010414	56.30	gold quality
caudate nucleus	UBERON:0001873	51.67	gold quality
skin of leg	UBERON:0001511	47.46	gold quality
vagina	UBERON:0000996	47.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Study determined that the expression of a novel circRNA, circIRAK3, was increased in metastatic breast cancer (BC) cells and predictive of BC recurrence and identified miR-3607 as a circIRAK3-associated miRNA. FOXC1 the target of miR-3607, was downregulated in circIRAK3-silenced cells and mediated circIRAK3-induced BC cell migration. FOXC1 in turn could bind to the IRAK3 promoter, triggering a positive-feedback loop. (PMID:29803789)
• MIR-3607 is downregulated in lymphatic invasion and in recurrent cancer colorectal cancer (CRC) patients and correlated with Pan-Cancer patient survival. Overexpression of miR-3607 decreases CRC cell proliferation, migration and invasion. MiR-3607 affects the DNA damage repair pathway by targeting DNA damage inducible 1 homolog 2 (DDI2). (PMID:31134446)
• Mapping the Molecular Basis and Markers of Papillary Thyroid Carcinoma Progression and Metastasis Using Global Transcriptome and microRNA Profiling. (PMID:32073999)
• miR-3607, a biomarker of hepatocellular carcinoma invasion and aggressiveness: Its relationship with epithelial-mesenchymal transition process. (PMID:32311821)
• Dysregulation of miR-3607 predicts prognosis of hepatocellular carcinoma and regulates tumor cell proliferation, migration and invasion. (PMID:32404179)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.