SNORD140

Summary

SNORD140 (small nucleolar RNA, C/D box 140, HGNC:51405) is a gene on chromosome 22q13.2.

At a glance

• GWAS associations: 1

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51405
Approved symbol	SNORD140
Name	small nucleolar RNA, C/D box 140
Location	22q13.2
Locus type	RNA, small nucleolar
Status	Approved
Entrez	106635682
RNAcentral	URS0000ABD8D1 — snoRNA, 120 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1001748439 (22:41075287 G>C), RS1002008799 (22:41074182 G>A,C), RS1002665415 (22:41073426 C>T), RS1003929044 (22:41074420 C>T), RS1005636415 (22:41073315 G>T), RS1008178030 (22:41075693 G>A), RS1008524230 (22:41075489 G>A), RS1010786527 (22:41073752 C>T), RS1010816323 (22:41074036 G>A), RS1016981405 (22:41073338 A>G), RS1019318363 (22:41075496 G>A), RS1021788142 (22:41074840 A>C), RS1022183908 (22:41074116 A>G), RS1022531106 (22:41073760 T>A), RS1025298202 (22:41073156 A>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004521_55	Autism spectrum disorder or schizophrenia	9.000000e-09

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Smoke	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.