SNORD16

Summary

SNORD16 (small nucleolar RNA, C/D box 16, HGNC:32712) is a small nucleolar RNA gene on chromosome 15q22.31.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 595097 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32712
Approved symbol	SNORD16
Name	small nucleolar RNA, C/D box 16
Location	15q22.31
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U16
Ensembl gene	ENSG00000199673
Ensembl biotype	snoRNA
Entrez	595097
RNAcentral	URS0000535D45 — snoRNA, 100 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000362803

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362803 — 1 exons

Exon	Start	End
ENSE00001437566	66502812	66502910

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 98.11.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1885 / max 16.1639, expressed in 83 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
150598	0.1885	83

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.11	gold quality
liver	UBERON:0002107	97.94	gold quality
adult mammalian kidney	UBERON:0000082	95.51	gold quality
lung	UBERON:0002048	95.49	gold quality
kidney	UBERON:0002113	93.92	gold quality
heart	UBERON:0000948	93.39	gold quality
adrenal tissue	UBERON:0018303	90.80	gold quality
intestine	UBERON:0000160	89.55	gold quality
colon	UBERON:0001155	88.46	gold quality
stomach	UBERON:0000945	87.78	gold quality
adrenal gland	UBERON:0002369	86.28	gold quality
blood	UBERON:0000178	77.75	gold quality
endometrium	UBERON:0001295	58.07	gold quality
prefrontal cortex	UBERON:0000451	52.20	gold quality
gastrocnemius	UBERON:0001388	46.11	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Small nucleolar RNAs in plasma extracellular vesicles and their discriminatory power as diagnostic biomarkers of Alzheimer’s disease. (PMID:34411703)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	SNORD16	ENSDARG00000110758
mus_musculus	Snord16a	ENSMUSG00000119388
rattus_norvegicus	SNORD16	ENSRNOG00000075279

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.