SNORD21

Summary

SNORD21 (small nucleolar RNA, C/D box 21, HGNC:10144) is a small nucleolar RNA gene on chromosome 1p22.1.

This gene encodes a small nucleolar RNA (snoRNA) that may be involved in biogenesis of the large (28S) ribosomal subunit. This gene is found within an intron of the RPL5 gene.

Source: NCBI Gene 6083 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10144
Approved symbol	SNORD21
Name	small nucleolar RNA, C/D box 21
Location	1p22.1
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U21
Ensembl gene	ENSG00000206680
Ensembl biotype	snoRNA
OMIM	603635
Entrez	6083
RNAcentral	URS00002E0A2C — snoRNA, 95 nt, 15 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000383953

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000383953 — 1 exons

Exon	Start	End
ENSE00001498963	92837289	92837383

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 99.75.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.75	gold quality
liver	UBERON:0002107	93.46	gold quality
adrenal tissue	UBERON:0018303	91.62	gold quality
lung	UBERON:0002048	90.52	gold quality
tibial nerve	UBERON:0001323	90.30	gold quality
calcaneal tendon	UBERON:0003701	88.89	gold quality
kidney	UBERON:0002113	85.43	gold quality
blood	UBERON:0000178	82.85	gold quality
myometrium	UBERON:0001296	82.50	gold quality
skeletal muscle tissue	UBERON:0001134	82.38	gold quality
adult mammalian kidney	UBERON:0000082	77.62	gold quality
heart	UBERON:0000948	77.49	gold quality
lymph node	UBERON:0000029	77.21	gold quality
muscle of leg	UBERON:0001383	76.07	gold quality
left lobe of thyroid gland	UBERON:0001120	75.26	gold quality
prostate gland	UBERON:0002367	74.78	gold quality
stomach	UBERON:0000945	74.59	gold quality
small intestine	UBERON:0002108	72.76	gold quality
islet of Langerhans	UBERON:0000006	72.74	gold quality
left adrenal gland cortex	UBERON:0035825	72.05	gold quality
prefrontal cortex	UBERON:0000451	70.17	gold quality
heart left ventricle	UBERON:0002084	69.66	gold quality
right atrium auricular region	UBERON:0006631	69.25	gold quality
vermiform appendix	UBERON:0001154	68.49	gold quality
intestine	UBERON:0000160	66.85	gold quality
gastrocnemius	UBERON:0001388	66.24	gold quality
body of stomach	UBERON:0001161	66.01	gold quality
skin of leg	UBERON:0001511	65.97	gold quality
tibial artery	UBERON:0007610	63.05	gold quality
Brodmann (1909) area 9	UBERON:0013540	62.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	SNORD21	ENSDARG00000082607
danio_rerio	SNORD21	ENSDARG00000082960
mus_musculus	Snord21	ENSMUSG00000064453
rattus_norvegicus	Snord21	ENSRNOG00000058679

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.