SNORD27

Summary

SNORD27 (small nucleolar RNA, C/D box 27, HGNC:10149) is a small nucleolar RNA gene on chromosome 11q12.3.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 9301 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10149
Approved symbol	SNORD27
Name	small nucleolar RNA, C/D box 27
Location	11q12.3
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U27
Ensembl gene	ENSG00000275996
Ensembl biotype	snoRNA
OMIM	603226
Entrez	9301
RNAcentral	URS000041615F — snoRNA, 72 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000363981

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000363981 — 1 exons

Exon	Start	End
ENSE00001438744	62855012	62855083

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 99.86.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.86	gold quality
lung	UBERON:0002048	97.36	gold quality
heart	UBERON:0000948	93.47	gold quality
kidney	UBERON:0002113	87.79	gold quality
adrenal tissue	UBERON:0018303	87.28	gold quality
calcaneal tendon	UBERON:0003701	86.57	gold quality
Brodmann (1909) area 9	UBERON:0013540	86.44	gold quality
liver	UBERON:0002107	85.20	gold quality
adult mammalian kidney	UBERON:0000082	85.16	gold quality
stomach	UBERON:0000945	83.10	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	79.69	gold quality
blood	UBERON:0000178	77.95	gold quality
intestine	UBERON:0000160	73.09	gold quality
islet of Langerhans	UBERON:0000006	72.60	gold quality
prostate gland	UBERON:0002367	68.74	gold quality
colon	UBERON:0001155	65.65	gold quality
monocyte	CL:0000576	64.65	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.79	gold quality
gastrocnemius	UBERON:0001388	63.25	gold quality
nucleus accumbens	UBERON:0001882	62.04	gold quality
anterior cingulate cortex	UBERON:0009835	60.36	gold quality
amygdala	UBERON:0001876	49.71	gold quality
right lobe of liver	UBERON:0001114	43.89	silver quality
caudate nucleus	UBERON:0001873	39.73	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Overexpression of SNORD27 is associated with high-risk smoldering multiple myeloma. (PMID:22331267)
• As part of a previously unidentified complex, SNORD27 regulates alternative splicing of the E2F7 pre-mRNA through direct RNA-RNA interaction without methylating the RNA, likely by competing with U1 snRNP. (PMID:26957605)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm24452	ENSMUSG00000065281
rattus_norvegicus	Snord27	ENSRNOG00000054315

Paralogs (1): SNORD27 (ENSG00000252128)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.