SNORD33

Summary

SNORD33 (small nucleolar RNA, C/D box 33, HGNC:10160) is a small nucleolar RNA gene on chromosome 19q13.33.

Predicted to be involved in RNA processing. Predicted to act upstream of or within glucose metabolic process; insulin secretion; and reactive oxygen species metabolic process. Predicted to be located in nucleolus.

Source: NCBI Gene 26818 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10160
Approved symbol	SNORD33
Name	small nucleolar RNA, C/D box 33
Location	19q13.33
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U33
Ensembl gene	ENSG00000199631
Ensembl biotype	snoRNA
Entrez	26818
RNAcentral	URS000008DC88 — snoRNA, 83 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000362761

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362761 — 1 exons

Exon	Start	End
ENSE00001437524	49490615	49490699

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 99.82.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7421 / max 162.8225, expressed in 295 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
176997	0.7421	295

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.82	gold quality
liver	UBERON:0002107	99.43	gold quality
adrenal tissue	UBERON:0018303	96.55	gold quality
lung	UBERON:0002048	95.64	gold quality
stomach	UBERON:0000945	94.89	gold quality
kidney	UBERON:0002113	92.79	gold quality
adult mammalian kidney	UBERON:0000082	91.23	gold quality
blood	UBERON:0000178	88.02	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.66	gold quality
calcaneal tendon	UBERON:0003701	86.19	gold quality
skeletal muscle tissue	UBERON:0001134	84.81	gold quality
adrenal gland	UBERON:0002369	82.66	gold quality
tibial nerve	UBERON:0001323	82.25	gold quality
spleen	UBERON:0002106	80.12	gold quality
duodenum	UBERON:0002114	79.14	gold quality
intestine	UBERON:0000160	77.92	gold quality
colon	UBERON:0001155	76.58	gold quality
lymph node	UBERON:0000029	75.29	gold quality
heart	UBERON:0000948	74.75	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.10	gold quality
prefrontal cortex	UBERON:0000451	73.96	gold quality
muscle of leg	UBERON:0001383	73.42	gold quality
islet of Langerhans	UBERON:0000006	73.30	gold quality
tonsil	UBERON:0002372	72.75	gold quality
right lobe of thyroid gland	UBERON:0001119	72.21	gold quality
body of stomach	UBERON:0001161	71.88	gold quality
placenta	UBERON:0001987	70.56	gold quality
monocyte	CL:0000576	69.95	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.88	gold quality
upper lobe of left lung	UBERON:0008952	67.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• A plasma SNORD33 signature predicts platinum benefit in metastatic triple-negative breast cancer patients. (PMID:35042534)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Snord33	ENSMUSG00002076766
rattus_norvegicus	Snord33	ENSRNOG00000053764

Paralogs (3): SNORD32B (ENSG00000201330), SNORD32A (ENSG00000201675), SNORD33 (ENSG00000252022)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.