SNORD42B

Summary

SNORD42B (small nucleolar RNA, C/D box 42B, HGNC:10181) is a small nucleolar RNA gene on chromosome 17q11.2.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 26808 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10181
Approved symbol	SNORD42B
Name	small nucleolar RNA, C/D box 42B
Location	17q11.2
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U42B
Ensembl gene	ENSG00000238423
Ensembl biotype	snoRNA
Entrez	26808
RNAcentral	URS000020C605 — snoRNA, 67 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000458893

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000458893 — 1 exons

Exon	Start	End
ENSE00001809259	28720550	28720616

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 99.42.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0706 / max 5.0579, expressed in 17 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
160058	0.0706	17

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.42	gold quality
bone marrow	UBERON:0002371	85.79	gold quality
duodenum	UBERON:0002114	85.65	gold quality
adrenal tissue	UBERON:0018303	85.46	gold quality
vermiform appendix	UBERON:0001154	83.93	gold quality
liver	UBERON:0002107	79.15	gold quality
lymph node	UBERON:0000029	79.13	gold quality
placenta	UBERON:0001987	78.98	gold quality
calcaneal tendon	UBERON:0003701	77.34	gold quality
monocyte	CL:0000576	76.36	gold quality
granulocyte	CL:0000094	75.48	gold quality
blood	UBERON:0000178	75.45	gold quality
muscle of leg	UBERON:0001383	74.53	gold quality
heart left ventricle	UBERON:0002084	74.22	gold quality
gastrocnemius	UBERON:0001388	73.98	gold quality
islet of Langerhans	UBERON:0000006	73.95	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.33	gold quality
kidney	UBERON:0002113	72.96	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.94	gold quality
ectocervix	UBERON:0012249	72.85	gold quality
right ovary	UBERON:0002118	72.57	gold quality
heart	UBERON:0000948	72.18	gold quality
fundus of stomach	UBERON:0001160	71.80	gold quality
stomach	UBERON:0000945	71.76	gold quality
urinary bladder	UBERON:0001255	71.41	gold quality
skin of abdomen	UBERON:0001416	71.26	gold quality
tibial artery	UBERON:0007610	70.95	gold quality
descending thoracic aorta	UBERON:0002345	70.64	gold quality
left adrenal gland cortex	UBERON:0035825	70.55	gold quality
right atrium auricular region	UBERON:0006631	70.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Plasma SNORD42B and SNORD111 as potential biomarkers for early diagnosis of non-small cell lung cancer. (PMID:36284435)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	SNORD42	ENSDARG00000082891
mus_musculus	Snord42b	ENSMUSG00000065676
rattus_norvegicus	Snord42b	ENSRNOG00000055722

Paralogs (3): SNORD42 (ENSG00000201209), SNORD42 (ENSG00000202440), SNORD42A (ENSG00000238649)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.