SNORD43

Summary

SNORD43 (small nucleolar RNA, C/D box 43, HGNC:10182) is a small nucleolar RNA gene on chromosome 22q13.1.

Intronic regions of ribosomal protein genes can harbor noncoding small nucleolar RNAs (snoRNAs), like SNORD43, which are generated during pre-mRNA processing. snoRNAs form part of the small nucleolar ribonucleoprotein particles (snoRNPs) involved in pre-rRNA processing and modification. snoRNAs of the box C/D class, like SNORD43, function in 2-prime-O-ribose methylation of rRNAs (Duga et al., 2000 [PubMed 10684968]).

Source: NCBI Gene 26807 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10182
Approved symbol	SNORD43
Name	small nucleolar RNA, C/D box 43
Location	22q13.1
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U43
Ensembl gene	ENSG00000263764
Ensembl biotype	snoRNA
OMIM	611068
Entrez	26807
RNAcentral	URS000022EFB6 — snoRNA, 62 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000583861

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583861 — 1 exons

Exon	Start	End
ENSE00002695643	39319050	39319113

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 98.12.

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.12	gold quality
bone marrow	UBERON:0002371	80.72	gold quality
adrenal tissue	UBERON:0018303	80.14	gold quality
liver	UBERON:0002107	79.42	gold quality
placenta	UBERON:0001987	78.80	gold quality
granulocyte	CL:0000094	78.25	gold quality
tonsil	UBERON:0002372	77.32	gold quality
lymph node	UBERON:0000029	77.04	gold quality
blood	UBERON:0000178	76.89	gold quality
calcaneal tendon	UBERON:0003701	76.73	gold quality
monocyte	CL:0000576	76.00	gold quality
islet of Langerhans	UBERON:0000006	75.32	gold quality
left adrenal gland cortex	UBERON:0035825	75.22	gold quality
rectum	UBERON:0001052	74.48	gold quality
right lobe of liver	UBERON:0001114	74.32	gold quality
pancreas	UBERON:0001264	73.66	gold quality
adrenal gland	UBERON:0002369	73.21	gold quality
gastrocnemius	UBERON:0001388	72.84	gold quality
urinary bladder	UBERON:0001255	72.66	gold quality
body of pancreas	UBERON:0001150	72.54	gold quality
stomach	UBERON:0000945	72.47	gold quality
left adrenal gland	UBERON:0001234	72.36	gold quality
body of stomach	UBERON:0001161	72.26	gold quality
adult mammalian kidney	UBERON:0000082	72.21	gold quality
right adrenal gland	UBERON:0001233	72.19	gold quality
heart left ventricle	UBERON:0002084	71.71	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.46	gold quality
prefrontal cortex	UBERON:0000451	71.42	gold quality
heart	UBERON:0000948	71.40	gold quality
apex of heart	UBERON:0002098	70.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.56

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Snord43	ENSRNOG00000052611

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.