SNORD45A

Summary

SNORD45A (small nucleolar RNA, C/D box 45A, HGNC:10184) is a small nucleolar RNA gene on chromosome 1p31.1.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 26805 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10184
Approved symbol	SNORD45A
Name	small nucleolar RNA, C/D box 45A
Location	1p31.1
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U45a
Ensembl gene	ENSG00000207241
Ensembl biotype	snoRNA
Entrez	26805
RNAcentral	URS00000A3335 — snoRNA, 84 nt, 9 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000384512

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384512 — 1 exons

Exon	Start	End
ENSE00001499520	75787889	75787972

Expression profiles

Bgee: expression breadth broad, 41 present calls, max score 98.82.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3404 / max 14.7425, expressed in 161 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
3552	0.3404	161

Top tissues by expression

41 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.82	gold quality
tibial nerve	UBERON:0001323	91.79	gold quality
liver	UBERON:0002107	91.32	gold quality
adrenal tissue	UBERON:0018303	89.85	gold quality
lung	UBERON:0002048	88.39	gold quality
stomach	UBERON:0000945	84.65	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.82	gold quality
heart	UBERON:0000948	80.63	gold quality
blood	UBERON:0000178	78.44	gold quality
muscle of leg	UBERON:0001383	78.33	gold quality
gastrocnemius	UBERON:0001388	76.93	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	76.82	gold quality
duodenum	UBERON:0002114	76.22	gold quality
body of stomach	UBERON:0001161	73.35	gold quality
amygdala	UBERON:0001876	72.59	gold quality
skeletal muscle tissue	UBERON:0001134	72.52	gold quality
colon	UBERON:0001155	70.44	gold quality
adult mammalian kidney	UBERON:0000082	69.34	gold quality
intestine	UBERON:0000160	68.68	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.07	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.22	gold quality
right atrium auricular region	UBERON:0006631	66.79	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.86	gold quality
Ammon’s horn	UBERON:0001954	64.41	gold quality
islet of Langerhans	UBERON:0000006	64.32	gold quality
left adrenal gland	UBERON:0001234	63.92	gold quality
caudate nucleus	UBERON:0001873	62.66	gold quality
heart left ventricle	UBERON:0002084	60.87	gold quality
tibial artery	UBERON:0007610	60.06	gold quality
right hemisphere of cerebellum	UBERON:0014890	59.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Down-regulation of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells. (PMID:28029658)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm24494	ENSMUSG00000065738
rattus_norvegicus	Snord45a	ENSRNOG00000053795

Paralogs (7): (ENSG00000200051), (ENSG00000200422), (ENSG00000200706), SNORD45B (ENSG00000201487), SNORD45C (ENSG00000206620), (ENSG00000252438), (ENSG00000276643)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.