SNORD50B

Summary

SNORD50B (small nucleolar RNA, C/D box 50B, HGNC:32722) is a small nucleolar RNA gene on chromosome 6q14.3.

SNORD50B is a C/D box-type small nucleolar RNA (snoRNA) that is predicted to function as a guide RNA in 2-prime O-methylation of 28S ribosomal RNA (Tanaka et al., 2000 [PubMed 10792466]).

Source: NCBI Gene 692088 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32722
Approved symbol	SNORD50B
Name	small nucleolar RNA, C/D box 50B
Location	6q14.3
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U50B
Ensembl gene	ENSG00000275072
Ensembl biotype	snoRNA
OMIM	613264
Entrez	692088
RNAcentral	URS000075DF75 — snoRNA, 71 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000364995

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000364995 — 1 exons

Exon	Start	End
ENSE00001808665	85677589	85677658

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 99.15.

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.15	gold quality
liver	UBERON:0002107	98.02	gold quality
tibial nerve	UBERON:0001323	83.03	gold quality
Brodmann (1909) area 9	UBERON:0013540	78.57	gold quality
lung	UBERON:0002048	72.23	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.30	gold quality
blood	UBERON:0000178	65.60	gold quality
brain	UBERON:0000955	65.25	gold quality
gastrocnemius	UBERON:0001388	64.89	gold quality
heart left ventricle	UBERON:0002084	64.53	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.11	gold quality
right frontal lobe	UBERON:0002810	58.53	gold quality
tibial artery	UBERON:0007610	53.21	gold quality
hypothalamus	UBERON:0001898	49.65	gold quality
amygdala	UBERON:0001876	47.92	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• SNORD50B directly binds and inhibits K-Ras and is recurrently deleted in human cancer. (PMID:26595770)
• SNORD50A/B RNAs shape the composition of proteins proximal to KRAS, notably by inhibiting KRAS proximity to the SNARE vesicular transport proteins (PMID:31712554)

Cross-species orthologs

0 orthologs

Paralogs (2): (ENSG00000199857), (ENSG00000202335)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.