SNORD53

Summary

SNORD53 (small nucleolar RNA, C/D box 53, HGNC:10203) is a small nucleolar RNA gene on chromosome 2p23.2.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 26796 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10203
Approved symbol	SNORD53
Name	small nucleolar RNA, C/D box 53
Location	2p23.2
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U53, SNORD53A
Ensembl gene	ENSG00000265145
Ensembl biotype	snoRNA
Entrez	26796
RNAcentral	URS000065DBA2 — snoRNA, 78 nt, 16 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000579969

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579969 — 1 exons

Exon	Start	End
ENSE00002731098	28927067	28927144

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 95.51.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0384 / max 14.6347, expressed in 12 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
19502	0.0384	12

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.51	gold quality
calcaneal tendon	UBERON:0003701	87.54	gold quality
adrenal tissue	UBERON:0018303	86.19	gold quality
vermiform appendix	UBERON:0001154	80.97	gold quality
liver	UBERON:0002107	80.95	gold quality
blood	UBERON:0000178	79.06	gold quality
adult mammalian kidney	UBERON:0000082	78.90	gold quality
bone marrow	UBERON:0002371	78.85	gold quality
kidney	UBERON:0002113	77.82	gold quality
muscle of leg	UBERON:0001383	77.13	gold quality
placenta	UBERON:0001987	76.94	gold quality
left uterine tube	UBERON:0001303	75.78	gold quality
Brodmann (1909) area 9	UBERON:0013540	75.49	gold quality
gastrocnemius	UBERON:0001388	74.88	gold quality
endometrium	UBERON:0001295	74.36	gold quality
monocyte	CL:0000576	73.76	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.11	gold quality
corpus callosum	UBERON:0002336	72.92	gold quality
stomach	UBERON:0000945	72.86	gold quality
islet of Langerhans	UBERON:0000006	72.43	gold quality
skin of abdomen	UBERON:0001416	72.36	gold quality
lung	UBERON:0002048	71.06	gold quality
zone of skin	UBERON:0000014	71.04	gold quality
skin of leg	UBERON:0001511	70.13	gold quality
heart	UBERON:0000948	69.69	gold quality
prefrontal cortex	UBERON:0000451	69.41	gold quality
fundus of stomach	UBERON:0001160	69.23	gold quality
urinary bladder	UBERON:0001255	69.17	gold quality
heart left ventricle	UBERON:0002084	68.73	gold quality
body of pancreas	UBERON:0001150	68.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.43

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000089164
danio_rerio		ENSDARG00000112988
danio_rerio		ENSDARG00000114381
mus_musculus	Snord53	ENSMUSG00000092887
rattus_norvegicus	Snord53	ENSRNOG00000054970

Paralogs (2): SNORD92 (ENSG00000264994), SNORD53B (ENSG00000265706)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.