SNORD53B

Summary

SNORD53B (small nucleolar RNA, C/D box 53B, HGNC:52229) is a small nucleolar RNA gene on chromosome 2p23.2.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 109617012 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52229
Approved symbol	SNORD53B
Name	small nucleolar RNA, C/D box 53B
Location	2p23.2
Locus type	RNA, small nucleolar
Status	Approved
Ensembl gene	ENSG00000265706
Ensembl biotype	snoRNA
Entrez	109617012
RNAcentral	URS00006C2FB0 — snoRNA, 78 nt, 9 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000577887

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577887 — 1 exons

Exon	Start	End
ENSE00002704319	28927983	28928060

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 95.64.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1411 / max 17.4796, expressed in 50 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
19503	0.1411	50

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.64	gold quality
duodenum	UBERON:0002114	90.38	gold quality
bone marrow	UBERON:0002371	86.04	gold quality
vermiform appendix	UBERON:0001154	84.75	gold quality
adrenal tissue	UBERON:0018303	84.29	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.13	gold quality
liver	UBERON:0002107	81.39	gold quality
calcaneal tendon	UBERON:0003701	81.15	gold quality
monocyte	CL:0000576	78.53	gold quality
placenta	UBERON:0001987	77.88	gold quality
endometrium	UBERON:0001295	77.46	gold quality
skin of abdomen	UBERON:0001416	77.08	gold quality
zone of skin	UBERON:0000014	76.78	gold quality
blood	UBERON:0000178	76.61	gold quality
skin of leg	UBERON:0001511	76.60	gold quality
gastrocnemius	UBERON:0001388	76.27	gold quality
kidney	UBERON:0002113	75.37	gold quality
right lobe of liver	UBERON:0001114	75.08	gold quality
smooth muscle tissue	UBERON:0001135	74.81	gold quality
rectum	UBERON:0001052	74.51	gold quality
islet of Langerhans	UBERON:0000006	74.30	gold quality
lymph node	UBERON:0000029	73.61	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.52	gold quality
right ovary	UBERON:0002118	73.40	gold quality
tibial nerve	UBERON:0001323	73.26	gold quality
subcutaneous adipose tissue	UBERON:0002190	73.25	gold quality
tibial artery	UBERON:0007610	73.24	gold quality
popliteal artery	UBERON:0002250	73.23	gold quality
lung	UBERON:0002048	73.12	gold quality
stomach	UBERON:0000945	72.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm22858	ENSMUSG00000092713
rattus_norvegicus	Snord53b	ENSRNOG00000060589

Paralogs (2): SNORD92 (ENSG00000264994), SNORD53 (ENSG00000265145)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.