SNORD57

Summary

SNORD57 (small nucleolar RNA, C/D box 57, HGNC:10207) is a small nucleolar RNA gene on chromosome 20p13.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 26792 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10207
Approved symbol	SNORD57
Name	small nucleolar RNA, C/D box 57
Location	20p13
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U57
Ensembl gene	ENSG00000226572
Ensembl biotype	snoRNA
Entrez	26792
RNAcentral	URS0000406CED — snoRNA, 72 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000448188

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000448188 — 1 exons

Exon	Start	End
ENSE00003614212	2656939	2657010

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 99.60.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3521 / max 54.2742, expressed in 134 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
183177	0.3521	134

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.60	gold quality
lung	UBERON:0002048	91.01	gold quality
liver	UBERON:0002107	87.54	gold quality
Brodmann (1909) area 9	UBERON:0013540	85.01	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	82.33	gold quality
adrenal tissue	UBERON:0018303	81.84	gold quality
stomach	UBERON:0000945	81.11	gold quality
heart	UBERON:0000948	79.92	gold quality
blood	UBERON:0000178	79.56	gold quality
multicellular organism	UBERON:0000468	79.13	gold quality
endometrium	UBERON:0001295	78.11	gold quality
calcaneal tendon	UBERON:0003701	77.81	gold quality
kidney	UBERON:0002113	76.22	gold quality
adult mammalian kidney	UBERON:0000082	71.13	gold quality
frontal cortex	UBERON:0001870	71.09	gold quality
gastrocnemius	UBERON:0001388	70.06	gold quality
intestine	UBERON:0000160	66.49	gold quality
colon	UBERON:0001155	63.28	gold quality
nucleus accumbens	UBERON:0001882	63.26	gold quality
right atrium auricular region	UBERON:0006631	59.64	gold quality
monocyte	CL:0000576	56.64	gold quality
tibial artery	UBERON:0007610	56.44	gold quality
subcutaneous adipose tissue	UBERON:0002190	54.55	gold quality
skin of leg	UBERON:0001511	38.32	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Circulating SNORD57 rather than piR-54265 is a promising biomarker for colorectal cancer: common pitfalls in the study of somatic piRNAs in cancer. (PMID:33376191)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000086733
mus_musculus	Snord57	ENSMUSG00000065272
rattus_norvegicus	Snord57	ENSRNOG00000056237

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.