SNORD59B

Summary

SNORD59B (small nucleolar RNA, C/D box 59B, HGNC:32723) is a gene on chromosome 12q13.3.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 692090 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32723
Approved symbol	SNORD59B
Name	small nucleolar RNA, C/D box 59B
Location	12q13.3
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U59B
Entrez	692090
RNAcentral	URS000075A693 — snoRNA, 75 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1002863394 (12:56644127 C>T), RS1005397457 (12:56644413 C>T), RS1005741224 (12:56645723 C>T), RS1005819048 (12:56645531 C>G), RS1006965729 (12:56645437 G>A), RS1007969986 (12:56643274 C>A,G,T), RS1009979070 (12:56644068 C>T), RS1014471579 (12:56643707 G>A), RS1014936551 (12:56644103 T>C), RS1015343946 (12:56644170 A>C), RS1019798839 (12:56644655 T>C), RS1020119339 (12:56645388 C>A,G,T), RS1020594832 (12:56645673 C>T), RS1022167789 (12:56644602 G>A), RS1023226582 (12:56645541 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression	1
versicolorin A	increases expression	1
MT19c compound	increases expression	1
Glyphosate	increases expression	1
Cadmium	decreases expression	1
Estradiol	decreases expression	1
Lactic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.