SNORD60

Summary

SNORD60 (small nucleolar RNA, C/D box 60, HGNC:10217) is a small nucleolar RNA gene on chromosome 16p13.3.

Predicted to be involved in RNA processing. Predicted to act upstream of or within intracellular cholesterol transport. Predicted to be located in nucleolus.

Source: NCBI Gene 26788 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10217
Approved symbol	SNORD60
Name	small nucleolar RNA, C/D box 60
Location	16p13.3
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U60
Ensembl gene	ENSG00000206630
Ensembl biotype	snoRNA
Entrez	26788
RNAcentral	URS000053336F — snoRNA, 83 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000383903

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000383903 — 1 exons

Exon	Start	End
ENSE00001498913	2155023	2155105

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 99.58.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1503 / max 17.2225, expressed in 46 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155902	0.1503	46

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.58	gold quality
lower esophagus mucosa	UBERON:0035834	95.80	gold quality
adrenal tissue	UBERON:0018303	94.07	gold quality
right uterine tube	UBERON:0001302	93.03	gold quality
mucosa of transverse colon	UBERON:0004991	92.51	gold quality
duodenum	UBERON:0002114	92.01	gold quality
adenohypophysis	UBERON:0002196	91.54	gold quality
skeletal muscle tissue	UBERON:0001134	91.07	gold quality
esophagus mucosa	UBERON:0002469	90.32	gold quality
lymph node	UBERON:0000029	90.09	gold quality
pituitary gland	UBERON:0000007	90.07	gold quality
liver	UBERON:0002107	89.71	gold quality
metanephros cortex	UBERON:0010533	89.46	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.18	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.98	gold quality
body of pancreas	UBERON:0001150	88.93	gold quality
skin of leg	UBERON:0001511	88.72	gold quality
minor salivary gland	UBERON:0001830	88.59	gold quality
saliva-secreting gland	UBERON:0001044	88.28	gold quality
spleen	UBERON:0002106	88.08	gold quality
left ovary	UBERON:0002119	88.01	gold quality
prostate gland	UBERON:0002367	87.90	gold quality
vagina	UBERON:0000996	87.87	gold quality
endometrium	UBERON:0001295	87.87	gold quality
right lobe of liver	UBERON:0001114	87.83	gold quality
transverse colon	UBERON:0001157	87.74	gold quality
zone of skin	UBERON:0000014	87.69	gold quality
ovary	UBERON:0000992	87.68	gold quality
right ovary	UBERON:0002118	87.46	gold quality
vermiform appendix	UBERON:0001154	87.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.24

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• SNORD60 promotes the tumorigenesis and progression of endometrial cancer through binding PIK3CA and regulating PI3K/AKT/mTOR signaling pathway. (PMID:36562475)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Snord60	ENSMUSG00000064768
rattus_norvegicus	Snord60	ENSRNOG00000057905

Paralogs (2): (ENSG00000199321), (ENSG00000252692)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.