SNORD64

Summary

SNORD64 (small nucleolar RNA, C/D box 64, HGNC:32725) is a small nucleolar RNA gene on chromosome 15q11.2.

This gene encodes a C/D box-type small nucleolar RNA that is expressed predominantly in the brain. Expression of this RNA is not detectable in the brains of patients with Prader-Willi syndrome.

Source: NCBI Gene 347686 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).
• Dosage sensitivity (ClinGen): haploinsufficiency no evidence, triplosensitivity no evidence

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32725
Approved symbol	SNORD64
Name	small nucleolar RNA, C/D box 64
Location	15q11.2
Locus type	RNA, small nucleolar
Status	Approved
Aliases	HBII-13
Ensembl gene	ENSG00000276610
Ensembl biotype	snoRNA
Entrez	347686
RNAcentral	URS00006A82CA — snoRNA, 67 nt, 10 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000386683

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000386683 — 1 exons

Exon	Start	End
ENSE00001501689	24985100	24985166

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 93.87.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9839 / max 434.1932, expressed in 276 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
145509	0.9839	276

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.87	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.76	gold quality
liver	UBERON:0002107	79.18	gold quality
tibial nerve	UBERON:0001323	74.07	gold quality
blood	UBERON:0000178	66.64	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.66	gold quality
tibial artery	UBERON:0007610	61.04	gold quality
omental fat pad	UBERON:0010414	60.10	gold quality
transverse colon	UBERON:0001157	58.41	gold quality
left coronary artery	UBERON:0001626	58.05	gold quality
skin of abdomen	UBERON:0001416	57.91	gold quality
skin of leg	UBERON:0001511	57.16	gold quality
Ammon’s horn	UBERON:0001954	56.39	gold quality
cerebellar hemisphere	UBERON:0002245	56.37	gold quality
amygdala	UBERON:0001876	54.25	gold quality
pituitary gland	UBERON:0000007	47.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Functional genomics

ClinGen dosage: haploinsufficiency 0 (no evidence), triplosensitivity 0 (no evidence). ClinGen Gene Dosage Map

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Snord64	ENSMUSG00000077191
rattus_norvegicus	Snord64	ENSRNOG00000064509

Paralogs (1): (ENSG00000212161)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.