SNORD78

Summary

SNORD78 (small nucleolar RNA, C/D box 78, HGNC:32738) is a gene on chromosome 1q25.1.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 692198 — RefSeq curated summary.

At a glance

• GWAS associations: 1

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32738
Approved symbol	SNORD78
Name	small nucleolar RNA, C/D box 78
Location	1q25.1
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U78
Entrez	692198
RNAcentral	URS00006CFC33 — snoRNA, 65 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000056001 (1:173867389 G>A), RS1000127752 (1:173867669 A>G), RS1000640330 (1:173867622 A>C,G), RS1002607397 (1:173866052 A>C), RS1002617054 (1:173865916 A>G), RS1002649601 (1:173865510 C>T), RS1003069702 (1:173865815 G>A), RS1004116595 (1:173865707 T>A,C), RS1004688779 (1:173867221 A>G), RS1004780584 (1:173867379 G>A), RS1006837276 (1:173865207 A>AT), RS1008511853 (1:173866575 G>A,T), RS1009037298 (1:173866222 A>G), RS1010200901 (1:173867102 T>A,G), RS1010958206 (1:173866454 CAT>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST005316_322	Intelligence (MTAG)	5.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004337	intelligence

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression	1
potassium chromate(VI)	affects cotreatment, increases expression	1
epigallocatechin gallate	increases expression, decreases expression, affects cotreatment	1
perfluorooctane sulfonic acid	decreases expression	1
Estradiol	increases expression	1
Valproic Acid	decreases methylation	1
Asbestos, Serpentine	affects methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.