SNORD8

Summary

SNORD8 (small nucleolar RNA, C/D box 8, HGNC:20159) is a small nucleolar RNA gene on chromosome 14q11.2.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 319103 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).
• Dosage sensitivity (ClinGen): haploinsufficiency no evidence, triplosensitivity no evidence

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20159
Approved symbol	SNORD8
Name	small nucleolar RNA, C/D box 8
Location	14q11.2
Locus type	RNA, small nucleolar
Status	Approved
Aliases	mgU6-53
Ensembl gene	ENSG00000200785
Ensembl biotype	snoRNA
OMIM	618943
Entrez	319103
RNAcentral	URS000075EE49 — snoRNA, 109 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000363915

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000363915 — 1 exons

Exon	Start	End
ENSE00001438678	21397292	21397401

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 99.79.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3710 / max 54.2742, expressed in 169 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
142166	0.3710	169

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.79	gold quality
adult mammalian kidney	UBERON:0000082	99.26	gold quality
kidney	UBERON:0002113	98.10	gold quality
liver	UBERON:0002107	94.98	gold quality
adrenal tissue	UBERON:0018303	94.95	gold quality
lung	UBERON:0002048	91.24	gold quality
stomach	UBERON:0000945	89.99	gold quality
blood	UBERON:0000178	88.33	gold quality
heart	UBERON:0000948	87.22	gold quality
adrenal gland	UBERON:0002369	83.57	gold quality
calcaneal tendon	UBERON:0003701	83.43	gold quality
intestine	UBERON:0000160	82.59	gold quality
Brodmann (1909) area 9	UBERON:0013540	81.93	gold quality
myometrium	UBERON:0001296	81.08	gold quality
muscle of leg	UBERON:0001383	80.54	gold quality
skeletal muscle tissue	UBERON:0001134	80.21	gold quality
colon	UBERON:0001155	78.73	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	78.17	gold quality
endometrium	UBERON:0001295	75.09	gold quality
gastrocnemius	UBERON:0001388	73.99	gold quality
prostate gland	UBERON:0002367	71.75	gold quality
ascending aorta	UBERON:0001496	71.27	gold quality
tibial nerve	UBERON:0001323	70.90	gold quality
tibial artery	UBERON:0007610	70.42	gold quality
esophagus mucosa	UBERON:0002469	69.31	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.62	gold quality
transverse colon	UBERON:0001157	68.56	gold quality
left adrenal gland	UBERON:0001234	68.42	gold quality
right atrium auricular region	UBERON:0006631	68.10	gold quality
caudate nucleus	UBERON:0001873	68.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Functional genomics

ClinGen dosage: haploinsufficiency 0 (no evidence), triplosensitivity 0 (no evidence). ClinGen Gene Dosage Map

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000080493
danio_rerio		ENSDARG00000081623
danio_rerio		ENSDARG00000083434
mus_musculus	Snord8	ENSMUSG00000093044
rattus_norvegicus	Snord8	ENSRNOG00000057709

Paralogs (1): SNORD9 (ENSG00000199436)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.