SNORD81

Summary

SNORD81 (small nucleolar RNA, C/D box 81, HGNC:10101) is a gene on chromosome 1q25.1.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 26769 — RefSeq curated summary.

At a glance

• GWAS associations: 2

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10101
Approved symbol	SNORD81
Name	small nucleolar RNA, C/D box 81
Location	1q25.1
Locus type	RNA, small nucleolar
Status	Approved
Aliases	Z23, U81
Entrez	26769
RNAcentral	URS000069573D — snoRNA, 77 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Intron Editing Reveals SNORD-Dependent Maturation of the Small Nucleolar RNA Host Gene GAS5 in Human Cells. (PMID:38139448)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 11 (showing top): chr1p22, PAX3_TARGET_GENES, ZNF781_TARGET_GENES, ZNF394_TARGET_GENES, ZNF697_TARGET_GENES, ZNF34_TARGET_GENES, ZNF555_TARGET_GENES, ZNF426_TARGET_GENES, ZNF490_TARGET_GENES, chr5p15, chr7q33

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3 predictions. Top by Δscore:

Variant	Effect	Δscore
7:137287760:G:C	acceptor_gain	0.2600
7:137287760:G:GC	acceptor_gain	0.2300
7:137287754:GATA:G	donor_gain	0.2100

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000390155 (1:173863801 A>G), RS1001615710 (1:173864655 C>A), RS1002607397 (1:173866052 A>C), RS1002617054 (1:173865916 A>G), RS1002649601 (1:173865510 C>T), RS1003069702 (1:173865815 G>A), RS1004116595 (1:173865707 T>A,C), RS1004256173 (1:173863706 A>C), RS1006508995 (1:173864095 A>G,T), RS1006837276 (1:173865207 A>AT), RS1009037298 (1:173866222 A>G), RS1011733118 (1:173865251 CCA>C), RS1012326934 (1:173864151 T>A), RS1012656431 (1:173865499 C>T), RS1016440963 (1:173864117 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST90020025_76	Waist-to-hip ratio adjusted for BMI	9.000000e-10
GCST90020027_1705	Waist-hip index	2.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007788	BMI-adjusted waist-hip ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Estradiol	increases expression	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.