SNORD86

Summary

SNORD86 (small nucleolar RNA, C/D box 86, HGNC:32745) is a small nucleolar RNA gene on chromosome 20p13.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 692201 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32745
Approved symbol	SNORD86
Name	small nucleolar RNA, C/D box 86
Location	20p13
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U86
Ensembl gene	ENSG00000212498
Ensembl biotype	snoRNA
Entrez	692201
RNAcentral	URS00003D103A — snoRNA, 86 nt, 24 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000391196

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000391196 — 1 exons

Exon	Start	End
ENSE00001508980	2656097	2656182

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 89.38.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7362 / max 17.3883, expressed in 343 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
183174	0.7362	343

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibial nerve	UBERON:0001323	89.38	gold quality
liver	UBERON:0002107	81.53	gold quality
skeletal muscle tissue	UBERON:0001134	78.02	gold quality
muscle of leg	UBERON:0001383	77.04	gold quality
right lobe of thyroid gland	UBERON:0001119	76.46	gold quality
heart	UBERON:0000948	71.51	gold quality
adipose tissue	UBERON:0001013	70.32	gold quality
heart left ventricle	UBERON:0002084	69.72	gold quality
blood	UBERON:0000178	65.22	gold quality
islet of Langerhans	UBERON:0000006	64.57	gold quality
small intestine	UBERON:0002108	63.02	gold quality
subcutaneous adipose tissue	UBERON:0002190	57.43	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	56.01	gold quality
colon	UBERON:0001155	49.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Excess snoRNP core proteins prevent further production of NOP56 and instead trigger the generation of a cytoplasmic snoRD86-containing NOP56-derived lncRNA via the nonsense-mediated decay pathway. (PMID:30220559)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm23187	ENSMUSG00000093645
rattus_norvegicus	Snord86	ENSRNOG00000051605

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.