SNX13

Summary

SNX13 (sorting nexin 13, HGNC:21335) is a protein-coding gene on chromosome 7p21.1, encoding Sorting nexin-13 (Q9Y5W8). May be involved in several stages of intracellular trafficking.

This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.

Source: NCBI Gene 23161 — RefSeq curated summary.

At a glance

• GWAS associations: 42
• Clinical variants (ClinVar): 151 total
• MANE Select transcript: NM_015132

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21335
Approved symbol	SNX13
Name	sorting nexin 13
Location	7p21.1
Locus type	gene with protein product
Status	Approved
Aliases	RGS-PX1, KIAA0713
Ensembl gene	ENSG00000071189
Ensembl biotype	protein_coding
OMIM	606589
Entrez	23161

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 16 protein_coding, 6 protein_coding_CDS_not_defined, 3 retained_intron, 2 nonsense_mediated_decay

ENST00000409076, ENST00000409604, ENST00000428135, ENST00000444712, ENST00000471744, ENST00000474067, ENST00000475800, ENST00000482558, ENST00000492626, ENST00000494402, ENST00000496855, ENST00000498463, ENST00000611725, ENST00000851062, ENST00000862559, ENST00000862560, ENST00000862561, ENST00000862562, ENST00000862563, ENST00000862564, ENST00000939179, ENST00000959594, ENST00000959595, ENST00000959596, ENST00000959597, ENST00000959598, ENST00000959599

RefSeq mRNA: 7 — MANE Select: NM_015132 NM_001350862, NM_001350863, NM_001350864, NM_001350866, NM_001350867, NM_001350870, NM_015132

CCDS: CCDS47551, CCDS87483

Canonical transcript exons

ENST00000428135 — 26 exons

Exon	Start	End
ENSE00001901974	17940284	17940494
ENSE00001943838	17790761	17794292
ENSE00003464604	17798690	17798758
ENSE00003475222	17834761	17834865
ENSE00003478331	17801588	17801659
ENSE00003513276	17830010	17830047
ENSE00003542600	17868407	17868490
ENSE00003552195	17875480	17875581
ENSE00003553103	17796827	17796939
ENSE00003562370	17826022	17826091
ENSE00003562468	17891546	17891635
ENSE00003564589	17839807	17840000
ENSE00003569490	17814834	17814944
ENSE00003589743	17803419	17803580
ENSE00003596806	17875669	17875790
ENSE00003613363	17850347	17850435
ENSE00003617802	17834052	17834184
ENSE00003623876	17850826	17850964
ENSE00003635272	17893332	17893434
ENSE00003641342	17873528	17873616
ENSE00003647840	17821509	17821648
ENSE00003650382	17816182	17816289
ENSE00003653354	17799009	17799154
ENSE00003662354	17897334	17897446
ENSE00003678596	17890363	17890484
ENSE00003694330	17845595	17845694

Expression profiles

Bgee: expression breadth ubiquitous, 286 present calls, max score 95.92.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 31.9218 / max 342.1206, expressed in 1817 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
82923	29.2867	1817
82918	1.2728	588
82922	0.9761	613
82921	0.3863	171

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	95.92	gold quality
calcaneal tendon	UBERON:0003701	95.22	gold quality
adrenal tissue	UBERON:0018303	94.30	gold quality
male germ cell	CL:0000015	93.85	gold quality
colonic epithelium	UBERON:0000397	93.29	gold quality
tibia	UBERON:0000979	92.22	gold quality
endothelial cell	CL:0000115	91.55	gold quality
Brodmann (1909) area 23	UBERON:0013554	90.86	gold quality
urethra	UBERON:0000057	90.73	gold quality
secondary oocyte	CL:0000655	90.15	gold quality
germinal epithelium of ovary	UBERON:0001304	90.14	gold quality
postcentral gyrus	UBERON:0002581	90.14	gold quality
lower lobe of lung	UBERON:0008949	89.87	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.78	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	89.56	gold quality
deltoid	UBERON:0001476	89.43	silver quality
rectum	UBERON:0001052	89.41	gold quality
parietal lobe	UBERON:0001872	89.33	gold quality
caput epididymis	UBERON:0004358	89.23	gold quality
biceps brachii	UBERON:0001507	89.16	gold quality
muscle of leg	UBERON:0001383	89.09	gold quality
superior frontal gyrus	UBERON:0002661	89.07	gold quality
islet of Langerhans	UBERON:0000006	88.98	gold quality
gastrocnemius	UBERON:0001388	88.96	gold quality
corpus callosum	UBERON:0002336	88.96	gold quality
cauda epididymis	UBERON:0004360	88.85	gold quality
tibialis anterior	UBERON:0001385	88.76	gold quality
upper leg skin	UBERON:0004262	88.70	gold quality
skin of hip	UBERON:0001554	88.58	gold quality
muscle organ	UBERON:0001630	88.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.72

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

194 targeting SNX13, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-590-3P	99.96	74.34	6478

Literature-anchored findings (GeneRIF, showing 1)

• CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export. (PMID:34936700)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	snx13	ENSDARG00000013828
mus_musculus	Snx13	ENSMUSG00000020590
rattus_norvegicus	Snx13	ENSRNOG00000004186
caenorhabditis_elegans		WBGENE00013803

Paralogs (3): SNX25 (ENSG00000109762), SNX19 (ENSG00000120451), SNX14 (ENSG00000135317)

Protein

Protein identifiers

Sorting nexin-13 — Q9Y5W8 (reviewed: Q9Y5W8)

Alternative names: RGS domain- and PHOX domain-containing protein, RGS-PX1

All UniProt accessions (5): Q9Y5W8, A0A087WUZ7, F8W8A9, F8WB11, Q9NSH0

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis. Acts as a GAP for Galphas.

Subcellular location. Early endosome membrane.

Domain organisation. The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the sorting nexin family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9Y5W8-1	1	yes
Q9Y5W8-2	2

RefSeq proteins (7): NP_001337791, NP_001337792, NP_001337793, NP_001337795, NP_001337796, NP_001337799, NP_055947* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001683	PX_dom	Domain
IPR003114	Phox_assoc	Domain
IPR013937	Sorting_nexin_C	Domain
IPR016137	RGS	Domain
IPR036305	RGS_sf	Homologous_superfamily
IPR036871	PX_dom_sf	Homologous_superfamily
IPR037437	SNX13_PX	Domain
IPR037896	SNX13_RGS	Domain
IPR044926	RGS_subdomain_2	Homologous_superfamily

Pfam: PF00615, PF00787, PF02194, PF08628

UniProt features (22 total): helix 8, binding site 4, domain 3, turn 2, chain 1, sequence conflict 1, strand 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7WF6	X-RAY DIFFRACTION	3.25

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y5W8-F1	76.68	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 612; 614; 639; 653

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 186 (showing top): FREAC2_01, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP, GOBP_REGULATION_OF_GTPASE_ACTIVITY, IVANOVA_HEMATOPOIESIS_MATURE_CELL, AREB6_01, YY1_Q6, GOBP_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY, GOBP_REGULATION_OF_HYDROLASE_ACTIVITY, GOBP_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION, YY1_02, KMCATNNWGGA_UNKNOWN, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, FREAC4_01

GO Biological Process (4): intracellular protein transport (GO:0006886), negative regulation of signal transduction (GO:0009968), positive regulation of GTPase activity (GO:0043547), protein transport (GO:0015031)

GO Molecular Function (3): phosphatidylinositol-3-phosphate binding (GO:0032266), phosphatidylinositol binding (GO:0035091), lipid binding (GO:0008289)

GO Cellular Component (4): early endosome (GO:0005769), early endosome membrane (GO:0031901), endosome (GO:0005768), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular protein localization	2
protein transport	1
intracellular transport	1
signal transduction	1
regulation of signal transduction	1
negative regulation of cell communication	1
negative regulation of signaling	1
negative regulation of response to stimulus	1
GTPase activity	1
regulation of GTPase activity	1
positive regulation of hydrolase activity	1
transport	1
establishment of protein localization	1
phosphatidylinositol phosphate binding	1
anion binding	1
binding	1
endosome	1
early endosome	1
endosome membrane	1
endomembrane system	1
cytoplasmic vesicle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1110 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SNX13	SERPINE2	P07093	812
SNX13	SAXO6	Q8TC05	615
SNX13	SNX17	Q15036	610
SNX13	SUCLG1	P53597	583
SNX13	BZW2	Q9Y6E2	560
SNX13	SNX27	Q96L92	559
SNX13	SNX2	P82862	555
SNX13	SNX3	O60493	547
SNX13	SNX1	Q13596	544
SNX13	ANKMY2	Q8IV38	542
SNX13	SNX14	Q9Y5W7	539
SNX13	HGS	O14964	533
SNX13	RGS7	P49802	531
SNX13	RGS21	Q2M5E4	531
SNX13	RGS13	O14921	521

IntAct

29 interactions, top by confidence:

A	B	Type	Score
IPPK	TMEM223	psi-mi:“MI:0914”(association)	0.530
CXCR4	TMEM120B	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM120B	psi-mi:“MI:0914”(association)	0.530
TSPAN2	TSPAN3	psi-mi:“MI:0914”(association)	0.530
SLC6A8	ILVBL	psi-mi:“MI:0914”(association)	0.530
SNX14	SNX13	psi-mi:“MI:0915”(physical association)	0.400
G6PC1	SNX13	psi-mi:“MI:0915”(physical association)	0.370
SNX13	NR1I3	psi-mi:“MI:0915”(physical association)	0.370
KLF15	SNX13	psi-mi:“MI:0915”(physical association)	0.370
SNX13	TDP2	psi-mi:“MI:0915”(physical association)	0.370
	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
	HLA-C	psi-mi:“MI:0914”(association)	0.350
TPRA1	BMPR1B	psi-mi:“MI:0914”(association)	0.350
TSPAN1	TLCD2	psi-mi:“MI:0914”(association)	0.350
IFITM3	PRAF2	psi-mi:“MI:0914”(association)	0.350
TSPAN2	TPP1	psi-mi:“MI:0914”(association)	0.350
HTR1B	SCAMP2	psi-mi:“MI:0914”(association)	0.350
ANKRD9	UBB	psi-mi:“MI:0914”(association)	0.350
CXCR4	ESYT2	psi-mi:“MI:0914”(association)	0.350
TSPAN2	GPD2	psi-mi:“MI:0914”(association)	0.350
SLC19A2	TMEM223	psi-mi:“MI:0914”(association)	0.350
SLC30A7	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC6A11	ILVBL	psi-mi:“MI:0914”(association)	0.350
SLC6A12	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC6A13	SPTLC2	psi-mi:“MI:0914”(association)	0.350
SLC6A4	RER1	psi-mi:“MI:0914”(association)	0.350
KRAS	IGKV2D-24	psi-mi:“MI:0914”(association)	0.350
FMR1	SNX13	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (35): SNX13 (Affinity Capture-MS), SNX13 (Affinity Capture-MS), SNX13 (Affinity Capture-MS), SNX13 (Affinity Capture-RNA), SNX13 (Proximity Label-MS), SNX13 (Affinity Capture-MS), SNX13 (Affinity Capture-MS), SNX13 (Affinity Capture-MS), SNX13 (Affinity Capture-MS), SNX13 (Affinity Capture-MS), SNX13 (Affinity Capture-MS), SNX13 (Affinity Capture-MS), SNX13 (Affinity Capture-MS), SNX13 (Affinity Capture-MS), GNAS (Reconstituted Complex)

ESM2 similar proteins: A0A8I6A2H6, A4IG32, A5D7A0, B1H2N3, D2HZB0, F1LNJ2, O70585, O75643, O88456, P04574, P04632, P06813, P07090, P13135, P22676, P23092, P46940, P47728, Q08331, Q0IIL1, Q1RMX9, Q3ZBY3, Q4FZY0, Q4KUS2, Q4R518, Q5PPL2, Q5RDF9, Q5RDI4, Q62768, Q64537, Q6NWD4, Q6P4T2, Q6P6Q9, Q6PHS6, Q7KZ85, Q86XE3, Q8C079, Q8VCX5, Q8WWF8, Q96C19

Diamond homologs: P40959, P57768, P57769, Q08DX0, Q3MPQ4, Q4FZZ1, Q559T8, Q5AG56, Q5PNP1, Q5R6Q7, Q5R7A7, Q5R903, Q7Z7A4, Q8BHY8, Q8BX57, Q8C080, Q8R4V0, Q8TEQ0, Q96BR1, Q9D3S3, Q9ERE3, Q9FG38, Q9Y5W7, Q9Y5W8, Q05B62, Q13596, Q4R503, Q6BIS2, Q99N27, Q9WV80, A1QZ05, B1AVY7, Q2KHV6, Q54TC3, Q54WZ5, Q6CUC4, Q6PHS6, Q75CC3, Q8CFD4, Q8IPH9

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 40 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
amino acid transport	5	42.2×	2e-05
sodium ion transmembrane transport	5	27.4×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

151 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	106
Likely benign	6
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

5424 predictions. Top by Δscore:

Variant	Effect	Δscore
7:17796938:CT:C	acceptor_gain	1.0000
7:17796940:C:CC	acceptor_gain	1.0000
7:17799003:TGCTA:T	donor_loss	1.0000
7:17799004:GCTAC:G	donor_loss	1.0000
7:17799005:CTACC:C	donor_loss	1.0000
7:17799006:TA:T	donor_loss	1.0000
7:17799007:A:C	donor_loss	1.0000
7:17799011:A:AC	donor_gain	1.0000
7:17799033:G:C	donor_gain	1.0000
7:17799067:T:TA	donor_gain	1.0000
7:17799071:TCGCA:T	donor_gain	1.0000
7:17799153:ACC:A	acceptor_loss	1.0000
7:17799156:T:A	acceptor_loss	1.0000
7:17801582:A:C	donor_gain	1.0000
7:17801582:ACTC:A	donor_loss	1.0000
7:17801584:TCAC:T	donor_loss	1.0000
7:17801586:A:AC	donor_gain	1.0000
7:17801587:C:CG	donor_gain	1.0000
7:17801587:CA:C	donor_gain	1.0000
7:17801587:CAT:C	donor_gain	1.0000
7:17801587:CATT:C	donor_gain	1.0000
7:17801587:CATTA:C	donor_gain	1.0000
7:17801656:GCAC:G	acceptor_gain	1.0000
7:17801657:CAC:C	acceptor_gain	1.0000
7:17801657:CACC:C	acceptor_gain	1.0000
7:17801660:C:CC	acceptor_gain	1.0000
7:17801661:T:C	acceptor_loss	1.0000
7:17801666:A:AC	acceptor_gain	1.0000
7:17801666:A:C	acceptor_gain	1.0000
7:17814829:CTTA:C	donor_gain	1.0000

AlphaMissense

6345 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000018529 (7:17845883 A>T), RS1000036935 (7:17920577 G>A), RS1000055823 (7:17849941 A>G), RS1000093182 (7:17934042 G>T), RS1000095738 (7:17882676 T>C), RS1000099832 (7:17888531 A>T), RS1000100151 (7:17810382 A>G), RS1000145730 (7:17822089 A>G), RS1000165215 (7:17823643 A>T), RS1000171214 (7:17934464 G>A), RS1000173402 (7:17899460 A>G), RS1000222651 (7:17815503 C>T), RS1000281483 (7:17855461 C>G), RS1000307471 (7:17807083 G>T), RS1000313056 (7:17940468 A>C,G)

Disease associations

OMIM: gene MIM:606589 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

42 associations (top):

Study	Trait	p-value
GCST002147_21	Fibrinogen	5.000000e-10
GCST002223_54	HDL cholesterol	9.000000e-12
GCST003123_17	Severe influenza A (H1N1) infection	7.000000e-11
GCST004121_31	Fibrinogen levels	1.000000e-12
GCST004122_5	Fibrinogen levels	1.000000e-11
GCST004232_37	HDL cholesterol levels	2.000000e-08
GCST004232_48	HDL cholesterol levels	1.000000e-16
GCST006013_2	Lactate dehydrogenase levels	5.000000e-09
GCST006014_13	Creatine kinase levels	2.000000e-09
GCST006611_24	HDL cholesterol	2.000000e-24
GCST006979_328	Heel bone mineral density	6.000000e-10
GCST008070_134	HDL cholesterol levels	2.000000e-06
GCST008070_64	HDL cholesterol levels	1.000000e-14
GCST008070_92	HDL cholesterol levels	1.000000e-08
GCST008074_89	Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	7.000000e-06
GCST008075_162	HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	1.000000e-28
GCST008075_220	HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	4.000000e-08
GCST008075_31	HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	2.000000e-19
GCST008084_124	HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	3.000000e-07
GCST008084_218	HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	4.000000e-29
GCST008084_41	HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	3.000000e-22
GCST008085_153	HDL cholesterol levels in current drinkers	2.000000e-10
GCST008085_64	HDL cholesterol levels in current drinkers	8.000000e-18
GCST008085_90	HDL cholesterol levels in current drinkers	3.000000e-07
GCST008087_10	Triglyceride levels in current drinkers	9.000000e-06
GCST008529_48	Tea consumption	7.000000e-07
GCST009360_3	LDL cholesterol levels x long total sleep time interaction (1df test)	3.000000e-06
GCST009366_11	LDL cholesterol levels x long total sleep time interaction (2df test)	2.000000e-09
GCST009367_68	HDL cholesterol levels x short total sleep time interaction (2df test)	5.000000e-12
GCST009602_62	Metabolic syndrome	3.000000e-09

EFO canonical traits (18, from GWAS)

EFO ID	Trait name
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:1001488	influenza A (H1N1)
EFO:0004808	L lactate dehydrogenase measurement
EFO:0004534	creatine kinase measurement
EFO:0009270	heel bone mineral density
EFO:0004530	triglyceride measurement
EFO:0004329	alcohol drinking
EFO:0010091	tea consumption measurement
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0000195	metabolic syndrome
EFO:0004502	adiponectin measurement
EFO:0004614	apolipoprotein A 1 measurement
EFO:0007874	gut microbiome measurement
EFO:0008336	disease progression measurement
EFO:0004980	appendicular lean mass
EFO:0004833	neutrophil count
EFO:0004736	aspartate aminotransferase measurement
EFO:0010099	chronic widespread pain

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression	5
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
arsenite	affects binding, decreases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
cobaltous chloride	increases expression	1
butyraldehyde	decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
azoxystrobin	decreases expression	1
CGP 52608	affects binding, increases reaction	1
torcetrapib	increases expression	1
pyrachlostrobin	decreases expression	1
jinfukang	decreases expression	1
picoxystrobin	decreases expression	1
Decitabine	decreases expression	1
Sunitinib	increases expression	1
Leflunomide	decreases expression	1
Antimycin A	decreases expression	1
Cadmium	increases abundance, increases expression	1
Caffeine	increases phosphorylation	1
Coumestrol	decreases expression	1
Doxorubicin	decreases expression	1
Hydrogen Peroxide	increases expression, affects cotreatment	1
Methyl Methanesulfonate	increases expression	1
Rotenone	decreases expression	1
Silicon Dioxide	decreases expression	1
Theophylline	affects cotreatment, increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E2KG	HAP1 SNX13 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.