SNX19

Summary

SNX19 (sorting nexin 19, HGNC:21532) is a protein-coding gene on chromosome 11q24.3-q25, encoding Sorting nexin-19 (Q92543). Plays a role in intracellular vesicle trafficking and exocytosis.

Islet antigen-2 (IA-2) is an autoantigen in type 1 diabetes and plays a role in insulin secretion. IA-2 is found in dense-core secretory vesicles and interacts with the product of this gene, a sorting nexin. In mouse pancreatic beta-cells, the encoded protein influenced insulin secretion by stabilizing the number of dense-core secretory vesicles.

Source: NCBI Gene 399979 — RefSeq curated summary.

At a glance

• GWAS associations: 20
• Clinical variants (ClinVar): 184 total — 2 pathogenic
• MANE Select transcript: NM_014758

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21532
Approved symbol	SNX19
Name	sorting nexin 19
Location	11q24.3-q25
Locus type	gene with protein product
Status	Approved
Aliases	KIAA0254, CHET8
Ensembl gene	ENSG00000120451
Ensembl biotype	protein_coding
Entrez	399979

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 6 protein_coding, 4 protein_coding_CDS_not_defined, 3 retained_intron

ENST00000265909, ENST00000426933, ENST00000524460, ENST00000526579, ENST00000527116, ENST00000527451, ENST00000528555, ENST00000530330, ENST00000530356, ENST00000531608, ENST00000533214, ENST00000533318, ENST00000534726

RefSeq mRNA: 12 — MANE Select: NM_014758 NM_001301089, NM_001347918, NM_001347919, NM_001347920, NM_001347921, NM_001347922, NM_001347923, NM_001347924, NM_001347925, NM_001347926, NM_001347927, NM_014758

CCDS: CCDS31721, CCDS73416, CCDS86260, CCDS86261

Canonical transcript exons

ENST00000265909 — 11 exons

Exon	Start	End
ENSE00001100145	130866250	130878554
ENSE00002197008	130914266	130916479
ENSE00003477865	130905953	130906133
ENSE00003515515	130906625	130906721
ENSE00003521354	130911633	130911771
ENSE00003568410	130880622	130880806
ENSE00003591737	130910270	130910370
ENSE00003605645	130907953	130908083
ENSE00003621693	130903255	130903384
ENSE00003638003	130879624	130879711
ENSE00003690319	130910018	130910137

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 95.97.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.1554 / max 190.8769, expressed in 1807 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
123179	26.3157	1807
123178	0.8995	629
123180	0.8841	547
123177	0.0560	15

Top tissues by expression

300 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	95.97	gold quality
islet of Langerhans	UBERON:0000006	94.09	gold quality
right coronary artery	UBERON:0001625	93.33	gold quality
adrenal tissue	UBERON:0018303	93.08	gold quality
medial globus pallidus	UBERON:0002477	92.85	gold quality
gall bladder	UBERON:0002110	92.81	gold quality
hindlimb stylopod muscle	UBERON:0004252	92.14	gold quality
globus pallidus	UBERON:0001875	92.03	gold quality
corpus callosum	UBERON:0002336	91.86	gold quality
popliteal artery	UBERON:0002250	91.60	gold quality
tibial artery	UBERON:0007610	91.58	gold quality
right adrenal gland cortex	UBERON:0035827	91.46	gold quality
lower esophagus muscularis layer	UBERON:0035833	91.45	gold quality
rectum	UBERON:0001052	91.43	gold quality
lower esophagus	UBERON:0013473	91.43	gold quality
smooth muscle tissue	UBERON:0001135	91.36	gold quality
pancreas	UBERON:0001264	91.31	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.28	gold quality
ganglionic eminence	UBERON:0004023	91.26	gold quality
sperm	CL:0000019	91.19	gold quality
muscle layer of sigmoid colon	UBERON:0035805	91.17	gold quality
aorta	UBERON:0000947	91.06	gold quality
left uterine tube	UBERON:0001303	91.03	gold quality
epithelium of nasopharynx	UBERON:0001951	91.02	gold quality
nasopharynx	UBERON:0001728	91.01	gold quality
body of pancreas	UBERON:0001150	91.00	gold quality
tonsil	UBERON:0002372	90.99	gold quality
right testis	UBERON:0004534	90.97	gold quality
stomach	UBERON:0000945	90.94	gold quality
body of stomach	UBERON:0001161	90.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

147 targeting SNX19, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-7978	99.86	66.90	856
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-576-5P	99.84	70.46	2582
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-489-3P	99.80	66.46	839
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093

Literature-anchored findings (GeneRIF, showing 3)

• Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19). (PMID:30635639)
• Single molecule in situ hybridization reveals distinct localizations of schizophrenia risk-related transcripts SNX19 and AS3MT in human brain. (PMID:33649454)
• SNX19 restricts endolysosome motility through contacts with the endoplasmic reticulum. (PMID:34315878)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	snx19a	ENSDARG00000061101
danio_rerio	snx19b	ENSDARG00000079931
mus_musculus	Snx19	ENSMUSG00000031993
rattus_norvegicus	Snx19	ENSRNOG00000014719

Paralogs (3): SNX13 (ENSG00000071189), SNX25 (ENSG00000109762), SNX14 (ENSG00000135317)

Protein

Protein identifiers

Sorting nexin-19 — Q92543 (reviewed: Q92543)

All UniProt accessions (4): Q92543, E7ERC7, E9PJV7, E9PLV3

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).

Subunit / interactions. Interacts with PTPRN.

Subcellular location. Early endosome membrane. Cytoplasmic vesicle membrane.

Domain organisation. The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).

Similarity. Belongs to the sorting nexin family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q92543-1	1	yes
Q92543-2	2

RefSeq proteins (12): NP_001288018, NP_001334847, NP_001334848, NP_001334849, NP_001334850, NP_001334851, NP_001334852, NP_001334853, NP_001334854, NP_001334855, NP_001334856, NP_055573* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001683	PX_dom	Domain
IPR003114	Phox_assoc	Domain
IPR013937	Sorting_nexin_C	Domain
IPR036871	PX_dom_sf	Homologous_superfamily
IPR037909	SNX19_PX	Domain

Pfam: PF00787, PF02194, PF08628

UniProt features (22 total): sequence variant 6, compositionally biased region 4, region of interest 4, splice variant 3, domain 2, binding site 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q92543-F1	61.47	0.12

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (2): 582; 629

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 132 (showing top): GOBP_CARTILAGE_DEVELOPMENT, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, GOBP_VESICLE_ORGANIZATION, GOBP_INSULIN_SECRETION, ASTON_MAJOR_DEPRESSIVE_DISORDER_DN, GOBP_REGULATION_OF_HORMONE_LEVELS, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, GOBP_HORMONE_TRANSPORT, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_CELL_CELL_SIGNALING, GOBP_ANATOMICAL_STRUCTURE_MATURATION, GOBP_EXOCYTOSIS, GOBP_SECRETORY_GRANULE_ORGANIZATION, GOBP_CHONDROCYTE_DIFFERENTIATION, GOBP_SECRETION

GO Biological Process (6): chondrocyte differentiation (GO:0002062), exocytosis (GO:0006887), insulin secretion (GO:0030073), establishment of localization in cell (GO:0051649), dense core granule maturation (GO:1990502), protein transport (GO:0015031)

GO Molecular Function (4): phosphatidylinositol-3-phosphate binding (GO:0032266), phosphatidylinositol binding (GO:0035091), protein binding (GO:0005515), lipid binding (GO:0008289)

GO Cellular Component (6): cytoplasm (GO:0005737), early endosome membrane (GO:0031901), endosome (GO:0005768), membrane (GO:0016020), cytoplasmic vesicle membrane (GO:0030659), cytoplasmic vesicle (GO:0031410)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
cellular anatomical structure	2
cytoplasmic vesicle	2
cell differentiation	1
cartilage development	1
vesicle-mediated transport	1
secretion by cell	1
vesicle fusion to plasma membrane	1
protein secretion	1
peptide hormone secretion	1
establishment of localization	1
cellular localization	1
secretory granule maturation	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
phosphatidylinositol phosphate binding	1
anion binding	1
intracellular anatomical structure	1
early endosome	1
endosome membrane	1
endomembrane system	1
vesicle membrane	1
cytoplasm	1
intracellular vesicle	1

Protein interactions and networks

STRING

814 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SNX19	SAXO6	Q8TC05	545
SNX19	NMRAL1	Q9HBL8	517
SNX19	PTPRN	Q16849	508
SNX19	ZNF513	Q8N8E2	487
SNX19	SNX15	Q9NRS6	468
SNX19	STARD3NL	O95772	455
SNX19	MAD1L1	Q9Y6D9	435
SNX19	SNX8	Q9Y5X2	432
SNX19	SNX11	Q9Y5W9	427
SNX19	SNX5	Q9Y5X3	412
SNX19	SNX17	Q15036	404
SNX19	SNX1	Q13596	404
SNX19	MATN1	P21941	404
SNX19	PPT2	Q9UMR5	404
SNX19	SNX27	Q96L92	401

IntAct

44 interactions, top by confidence:

A	B	Type	Score
TSPAN5	ADAM10	psi-mi:“MI:0914”(association)	0.800
VAPB	FAM83G	psi-mi:“MI:0914”(association)	0.730
SNX19	PTPRN	psi-mi:“MI:0915”(physical association)	0.510
PTPRN	SNX19	psi-mi:“MI:0915”(physical association)	0.510
	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC15A3		psi-mi:“MI:0914”(association)	0.350
UNC93B1		psi-mi:“MI:0914”(association)	0.350
ATP6V0D1		psi-mi:“MI:0914”(association)	0.350
MYC		psi-mi:“MI:0914”(association)	0.350
RTN3	ESYT2	psi-mi:“MI:0914”(association)	0.350
TSPAN15	TMEM223	psi-mi:“MI:0914”(association)	0.350
TSPAN8	POTEF	psi-mi:“MI:0914”(association)	0.350
SLC6A5	SCAMP3	psi-mi:“MI:0914”(association)	0.350
HLA-F	KDM5C	psi-mi:“MI:0914”(association)	0.350
APH1A	SNX19	psi-mi:“MI:0914”(association)	0.350
FZD10	PDE2A	psi-mi:“MI:0914”(association)	0.350
SLC15A2	LGALS8	psi-mi:“MI:0914”(association)	0.350
SLC19A2	TMEM223	psi-mi:“MI:0914”(association)	0.350
SLC22A9	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC27A6	NBAS	psi-mi:“MI:0914”(association)	0.350
SLC2A8	AP3D1	psi-mi:“MI:0914”(association)	0.350
SLC30A4	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC35C2	PGRMC1	psi-mi:“MI:0914”(association)	0.350
SLC35F1	C15orf61	psi-mi:“MI:0914”(association)	0.350
SLC35F2	EI24	psi-mi:“MI:0914”(association)	0.350
SLC35F3	TMEM223	psi-mi:“MI:0914”(association)	0.350
SLC39A14	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC39A4	ESYT2	psi-mi:“MI:0914”(association)	0.350

BioGRID (102): SNX19 (Reconstituted Complex), SNX19 (Proximity Label-MS), SNX19 (Affinity Capture-MS), SNX19 (Proximity Label-MS), SNX19 (Proximity Label-MS), SNX19 (Affinity Capture-MS), SNX19 (Affinity Capture-RNA), SNX19 (Two-hybrid), SNX19 (Affinity Capture-Western), PTPRN (Affinity Capture-Western), SNX19 (Affinity Capture-RNA), SNX19 (Affinity Capture-MS), SNX19 (Affinity Capture-MS), SNX19 (Proximity Label-MS), SNX19 (Affinity Capture-MS)

ESM2 similar proteins: A1L3T7, A2AKB4, A2RU30, A5GFW5, A6NP61, A6QLD5, A7E316, B1ASB6, P60924, Q08DK9, Q1XFL1, Q2TAK8, Q2YDQ5, Q3TD16, Q3TYX8, Q3U132, Q3U1D0, Q400C9, Q49AM3, Q571B6, Q5JXC2, Q5JYT7, Q5RA50, Q5SYB0, Q66IK8, Q6DIL6, Q6GQ34, Q6IRU7, Q6P1D7, Q6P1H6, Q6P4T1, Q7TNY7, Q7TSI1, Q7Z572, Q80XI1, Q86V42, Q8BG26, Q8BLQ0, Q8BP86, Q8BVF9

Diamond homologs: Q6P4T1, Q92543

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 59 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
R-HSA-425366	6	27.9×	6e-06
SLC-mediated transmembrane transport	10	15.2×	1e-07
Transport of small molecules	10	6.5×	1e-04

GO biological processes:

GO term	Partners	Fold	FDR
amino acid transport	5	30.0×	2e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

184 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	0
Uncertain significance	147
Likely benign	12
Benign	3

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
161071	GRCh38/hg38 11q23.3-25(chr11:116851395-134998513)x3	Pathogenic
1694653	GRCh37/hg19 11q24.3-25(chr11:128634685-134257741)x1	Pathogenic

SpliceAI

2152 predictions. Top by Δscore:

Variant	Effect	Δscore
11:130879619:CTTA:C	donor_loss	1.0000
11:130879620:TTAC:T	donor_loss	1.0000
11:130879621:TA:T	donor_loss	1.0000
11:130879622:A:AC	donor_gain	1.0000
11:130879622:ACCTG:A	donor_loss	1.0000
11:130879623:C:CC	donor_gain	1.0000
11:130879623:C:CG	donor_loss	1.0000
11:130879623:CCTG:C	donor_gain	1.0000
11:130879709:GAT:G	acceptor_gain	1.0000
11:130879710:AT:A	acceptor_gain	1.0000
11:130879710:ATC:A	acceptor_loss	1.0000
11:130879712:C:CC	acceptor_gain	1.0000
11:130880617:ATTAC:A	donor_loss	1.0000
11:130880618:TTA:T	donor_loss	1.0000
11:130880619:TA:T	donor_loss	1.0000
11:130880620:ACC:A	donor_loss	1.0000
11:130880621:CCTGG:C	donor_loss	1.0000
11:130883701:AGG:A	donor_gain	1.0000
11:130883726:ATTT:A	donor_gain	1.0000
11:130905948:CTCA:C	donor_loss	1.0000
11:130905949:TCAC:T	donor_loss	1.0000
11:130905950:CACC:C	donor_loss	1.0000
11:130905952:C:CG	donor_loss	1.0000
11:130907928:C:A	donor_gain	1.0000
11:130907951:A:AC	donor_gain	1.0000
11:130907952:C:CC	donor_gain	1.0000
11:130907952:CTTG:C	donor_gain	1.0000
11:130910375:C:CT	acceptor_gain	1.0000
11:130910376:A:T	acceptor_gain	1.0000
11:130911626:T:TA	donor_gain	1.0000

AlphaMissense

6430 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:130910088:A:G	F655S	0.999
11:130911680:A:G	L589P	0.999
11:130911689:A:G	F586S	0.999
11:130911705:G:T	R581S	0.999
11:130910087:G:C	F655L	0.998
11:130910087:G:T	F655L	0.998
11:130910089:A:G	F655L	0.998
11:130910274:A:G	L637P	0.998
11:130911668:A:G	L593P	0.998
11:130911688:G:C	F586L	0.998
11:130911688:G:T	F586L	0.998
11:130911690:A:G	F586L	0.998
11:130911704:C:G	R581P	0.998
11:130910054:A:C	F666L	0.997
11:130910054:A:T	F666L	0.997
11:130910056:A:G	F666L	0.997
11:130910133:A:G	L640P	0.997
11:130910286:A:G	L633P	0.997
11:130914336:A:G	I535T	0.997
11:130910085:A:G	L656P	0.996
11:130910358:G:T	P609H	0.996
11:130911671:C:G	R592P	0.996
11:130911693:C:T	E585K	0.996
11:130911771:A:C	Y559D	0.996
11:130914277:A:C	Y555D	0.996
11:130914336:A:C	I535S	0.996
11:130910294:C:A	K630N	0.995
11:130910294:C:G	K630N	0.995
11:130911692:T:A	E585V	0.995
11:130914336:A:T	I535N	0.995

dbSNP variants (sampled 300 via entrez): RS1000128147 (11:130892333 T>C), RS1000165439 (11:130873491 G>A), RS1000188439 (11:130868052 G>A,C), RS1000201090 (11:130901725 C>T), RS1000243244 (11:130866652 C>A), RS1000380572 (11:130874573 C>G,T), RS1000445312 (11:130881111 G>A), RS1000477839 (11:130891926 C>G,T), RS1000539997 (11:130916714 C>G), RS1000610125 (11:130918118 C>T), RS1000621679 (11:130896631 G>A), RS1000643291 (11:130909066 A>G), RS1000647487 (11:130874812 A>G), RS1000720783 (11:130866949 T>A,C), RS1000804605 (11:130903144 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

20 associations (top):

Study	Trait	p-value
GCST002149_9	Schizophrenia	2.000000e-09
GCST002337_94	Amyotrophic lateral sclerosis (sporadic)	9.000000e-06
GCST002539_11	Schizophrenia	1.000000e-12
GCST004521_36	Autism spectrum disorder or schizophrenia	1.000000e-08
GCST004521_37	Autism spectrum disorder or schizophrenia	1.000000e-08
GCST004946_53	Schizophrenia	2.000000e-08
GCST006629_33	Pulse pressure	8.000000e-13
GCST006803_96	Schizophrenia	2.000000e-11
GCST007096_198	Pulse pressure	4.000000e-08
GCST007201_127	Schizophrenia	9.000000e-09
GCST007201_316	Schizophrenia	2.000000e-08
GCST007269_312	Pulse pressure	2.000000e-08
GCST007293_105	Body fat distribution (arm fat ratio)	5.000000e-06
GCST007293_87	Body fat distribution (arm fat ratio)	4.000000e-07
GCST009391_610	Metabolite levels	1.000000e-07
GCST009391_668	Metabolite levels	3.000000e-06
GCST009600_124	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy)	2.000000e-09
GCST009600_96	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy)	2.000000e-10
GCST010988_432	Adult body size	5.000000e-10
GCST012490_552	Femur bone mineral density x serum urate levels interaction	6.000000e-09

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0005763	pulse pressure measurement
EFO:0004341	body fat distribution
EFO:0009793	isoleucine measurement
EFO:0009770	leucine measurement
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects methylation, increases expression	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, increases methylation	1
beta-lapachone	increases expression	1
cobaltous chloride	decreases expression	1
arsenic disulfide	increases methylation	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation, decreases methylation	1
Acetaminophen	decreases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Carbamazepine	affects expression	1
Doxorubicin	decreases expression	1
Methotrexate	increases expression	1
Methyl Methanesulfonate	increases expression	1
Smoke	decreases expression	1
Valproic Acid	increases expression	1
Aflatoxin B1	decreases methylation	1
Sodium Selenite	increases expression	1

Cellosaurus cell lines

5 cell lines: 5 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E2KH	HAP1 SNX19 (-) 2	Cancer cell line	Male
CVCL_E2KI	HAP1 SNX19 (-) 3	Cancer cell line	Male
CVCL_E2KJ	HAP1 SNX19 (-) 4	Cancer cell line	Male
CVCL_E2KK	HAP1 SNX19 (-) 5	Cancer cell line	Male
CVCL_XT63	HAP1 SNX19 (-) 1	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.