SNX33

Summary

SNX33 (sorting nexin 33, HGNC:28468) is a protein-coding gene on chromosome 15q24.2, encoding Sorting nexin-33 (Q8WV41). Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2.

The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 257364 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 86 total
• MANE Select transcript: NM_153271

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28468
Approved symbol	SNX33
Name	sorting nexin 33
Location	15q24.2
Locus type	gene with protein product
Status	Approved
Aliases	MGC32065, SH3PXD3C, SNX30
Ensembl gene	ENSG00000173548
Ensembl biotype	protein_coding
OMIM	619107
Entrez	257364

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000308527, ENST00000569152

RefSeq mRNA: 2 — MANE Select: NM_153271 NM_001318146, NM_153271

CCDS: CCDS10283

Canonical transcript exons

ENST00000308527 — 2 exons

Exon	Start	End
ENSE00001208398	75647912	75650573
ENSE00001876892	75656962	75662301

Expression profiles

Bgee: expression breadth ubiquitous, 249 present calls, max score 96.35.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.1258 / max 73.9449, expressed in 1694 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
147819	8.6909	1633
147818	1.4349	1050

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	96.35	gold quality
lower esophagus mucosa	UBERON:0035834	95.17	gold quality
tendon of biceps brachii	UBERON:0008188	95.01	gold quality
esophagus mucosa	UBERON:0002469	90.68	gold quality
cardiac muscle of right atrium	UBERON:0003379	90.66	silver quality
parotid gland	UBERON:0001831	90.65	gold quality
right coronary artery	UBERON:0001625	90.55	gold quality
popliteal artery	UBERON:0002250	90.48	gold quality
tibial artery	UBERON:0007610	90.46	gold quality
aorta	UBERON:0000947	90.31	gold quality
descending thoracic aorta	UBERON:0002345	90.27	gold quality
ascending aorta	UBERON:0001496	90.24	gold quality
thoracic aorta	UBERON:0001515	90.21	gold quality
stromal cell of endometrium	CL:0002255	90.02	gold quality
ectocervix	UBERON:0012249	89.46	gold quality
vagina	UBERON:0000996	88.91	gold quality
skin of leg	UBERON:0001511	88.90	gold quality
esophagus	UBERON:0001043	88.89	gold quality
body of pancreas	UBERON:0001150	88.88	gold quality
endocervix	UBERON:0000458	88.70	gold quality
upper arm skin	UBERON:0004263	88.70	silver quality
right ovary	UBERON:0002118	88.28	gold quality
skin of abdomen	UBERON:0001416	88.11	gold quality
left ovary	UBERON:0002119	88.03	gold quality
apex of heart	UBERON:0002098	87.82	gold quality
left coronary artery	UBERON:0001626	87.76	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	87.72	gold quality
subcutaneous adipose tissue	UBERON:0002190	87.58	gold quality
mucosa of stomach	UBERON:0001199	87.52	gold quality
zone of skin	UBERON:0000014	87.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.26

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

63 targeting SNX33, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-3065-3P	99.87	70.25	1407
HSA-MIR-4779	99.86	66.50	1583
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-3175	99.65	66.30	2031
HSA-MIR-4690-5P	99.65	66.24	813
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-6081	99.48	66.07	1446
HSA-MIR-6722-3P	99.45	67.62	1919

Literature-anchored findings (GeneRIF, showing 7)

• identifies SNX33 as a new endocytic protein, which modulates amyloid precursor protein endocytosis and APP alpha-secretase cleavage, and demonstrates that the rate of APP endocytosis is a major control factor for APP alpha-secretase cleavage (PMID:18353773)
• SNX33 interferes with cellular PrP formation by modulation of PrP shedding (PMID:18419754)
• SNX33 plays a role in maintaining cell shape and cell cycle progression through its interaction with WASp (PMID:19487689)
• Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins SNX33 and nephrocystin (PMID:19718658)
• study identifies critical amino acids within the BAR domains of SNX9 and SNX33 as determinants for the specificity of BAR domain-mediated interactions and suggests that SNX9 and SNX33 have distinct molecular functions. (PMID:20964629)
• The sorting nexin 9 (SNX9) subfamily members - SNX9, SNX18 and SNX33 - are required for progression and completion of mitosis. (PMID:22718350)
• [Donepezil Reduces Amyloid Precursor Protein Endocytosis by Resulting from Increase in the Expression of Sorting Nexin Protein 33]. (PMID:34078793)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	snx33	ENSDARG00000014954
mus_musculus	Snx33	ENSMUSG00000032733
rattus_norvegicus	Snx33	ENSRNOG00000017382
drosophila_melanogaster	Snx1	FBGN0031534
drosophila_melanogaster	Snx6	FBGN0032005
caenorhabditis_elegans		WBGENE00004927
caenorhabditis_elegans		WBGENE00013354

Paralogs (15): SNX11 (ENSG00000002919), SNX1 (ENSG00000028528), SNX10 (ENSG00000086300), SNX5 (ENSG00000089006), SNX8 (ENSG00000106266), SNX3 (ENSG00000112335), SNX4 (ENSG00000114520), SNX6 (ENSG00000129515), SNX9 (ENSG00000130340), SNX12 (ENSG00000147164), SNX30 (ENSG00000148158), SNX7 (ENSG00000162627), SNX32 (ENSG00000172803), SNX18 (ENSG00000178996), SNX2 (ENSG00000205302)

Protein

Protein identifiers

Sorting nexin-33 — Q8WV41 (reviewed: Q8WV41)

Alternative names: SH3 and PX domain-containing protein 3

All UniProt accessions (2): Q8WV41, H3BPR3

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.

Subunit / interactions. Homodimer (via BAR domain). Interacts with ADAM15. Interacts with FASLG. Interacts (via SH3 domain) with DNM1 and DNM2. Interacts with WASL. Interacts with FCHSD1 (via the F-BAR domain).

Subcellular location. Cytoplasm. Cytosol. Membrane. Cytoplasmic vesicle membrane.

Tissue specificity. Detected in heart and pancreas.

Post-translational modifications. Phosphorylated.

Domain organisation. The PX and BAR domains mediate association with membranes and are required for membrane tubulation.

Similarity. Belongs to the sorting nexin family.

RefSeq proteins (2): NP_001305075, NP_695003* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001452	SH3_domain	Domain
IPR001683	PX_dom	Domain
IPR014536	Snx9_fam	Family
IPR019497	Sorting_nexin_WASP-bd-dom	Domain
IPR027267	AH/BAR_dom_sf	Homologous_superfamily
IPR036028	SH3-like_dom_sf	Homologous_superfamily
IPR036871	PX_dom_sf	Homologous_superfamily
IPR037427	SNX33_BAR	Domain

Pfam: PF00787, PF10456, PF14604

UniProt features (30 total): helix 14, strand 7, domain 3, modified residue 2, chain 1, turn 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
4AKV	X-RAY DIFFRACTION	2.65

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WV41-F1	82.62	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 77, 92

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 368 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_MCMV_INFECTION_UP, GSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_UP, GOBP_MITOTIC_CYTOKINESIS, GGGACCA_MIR133A_MIR133B, GOBP_REGULATION_OF_AUTOPHAGY, GOBP_PINOCYTOSIS, GOBP_ENDOSOME_ORGANIZATION, GOBP_VACUOLE_ORGANIZATION, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GOBP_VESICLE_ORGANIZATION, GOBP_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION, GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION, GOBP_PLASMA_MEMBRANE_ORGANIZATION, GOBP_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS

GO Biological Process (17): mitotic cytokinesis (GO:0000281), intracellular protein transport (GO:0006886), endocytosis (GO:0006897), endosome organization (GO:0007032), endosomal transport (GO:0016197), protein import (GO:0017038), cleavage furrow formation (GO:0036089), macropinocytosis (GO:0044351), negative regulation of endocytosis (GO:0045806), positive regulation of membrane protein ectodomain proteolysis (GO:0051044), plasma membrane tubulation (GO:0097320), negative regulation of protein localization to cell surface (GO:2000009), positive regulation of protein localization to cell surface (GO:2000010), mitotic cell cycle (GO:0000278), positive regulation of catabolic process (GO:0009896), protein transport (GO:0015031), cell division (GO:0051301)

GO Molecular Function (3): phosphatidylinositol binding (GO:0035091), identical protein binding (GO:0042802), protein binding (GO:0005515)

GO Cellular Component (6): cytosol (GO:0005829), plasma membrane (GO:0005886), membrane (GO:0016020), cytoplasmic vesicle membrane (GO:0030659), cytoplasmic vesicle (GO:0031410), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
cytoskeleton-dependent cytokinesis	2
intracellular protein localization	2
protein transport	2
intracellular transport	2
vesicle-mediated transport	2
protein localization to cell surface	2
regulation of protein localization to cell surface	2
cytoplasm	2
mitotic cell cycle	1
mitotic cell cycle process	1
vesicle budding from membrane	1
membrane invagination	1
import into cell	1
endomembrane system organization	1
vesicle organization	1
cytokinetic process	1
plasma membrane invagination	1
pinocytosis	1
endocytosis	1
regulation of endocytosis	1
negative regulation of transport	1
negative regulation of cellular component organization	1
membrane protein ectodomain proteolysis	1
positive regulation of protein catabolic process	1
positive regulation of proteolysis	1
regulation of membrane protein ectodomain proteolysis	1
plasma membrane organization	1
negative regulation of protein localization	1
positive regulation of protein localization	1
cell cycle	1
mitotic nuclear division	1
catabolic process	1
positive regulation of metabolic process	1
regulation of catabolic process	1
transport	1
establishment of protein localization	1
cellular process	1
anion binding	1
protein binding	1

Protein interactions and networks

STRING

754 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SNX33	ENC1	O14682	642
SNX33	SNX12	Q9UMY4	638
SNX33	SNX32	Q86XE0	637
SNX33	SNX6	Q9UNH7	631
SNX33	SNX17	Q15036	610
SNX33	SNX15	Q9NRS6	608
SNX33	SNX5	Q9Y5X3	585
SNX33	SNX4	O95219	559
SNX33	CIBAR2	Q6ZTR7	519
SNX33	GPR85	P60893	515
SNX33	DNM1	Q05193	513
SNX33	BACE1	P56817	505
SNX33	SNX27	Q96L92	500
SNX33	AMPH	P49418	487
SNX33	SNX11	Q9Y5W9	477

IntAct

122 interactions, top by confidence:

A	B	Type	Score
ANKRD54	TULP3	psi-mi:“MI:0914”(association)	0.930
FASLG	SNX33	psi-mi:“MI:0915”(physical association)	0.780
DNM2	DNM1	psi-mi:“MI:0914”(association)	0.740
KBTBD7	METTL15	psi-mi:“MI:0914”(association)	0.730
ADAM15	SNX33	psi-mi:“MI:0407”(direct interaction)	0.710
ADAM15	SNX33	psi-mi:“MI:0915”(physical association)	0.710
SNX33	NAF1	psi-mi:“MI:0915”(physical association)	0.670
NAA10	SNX33	psi-mi:“MI:0915”(physical association)	0.670
YWHAG	SNX33	psi-mi:“MI:0915”(physical association)	0.670
DNM2	SNX33	psi-mi:“MI:0915”(physical association)	0.670
GPR156	PLD2	psi-mi:“MI:0914”(association)	0.640
FASLG	PRMT2	psi-mi:“MI:0914”(association)	0.640
SDC2	PDPK1	psi-mi:“MI:0914”(association)	0.640
NCKIPSD	GEMIN2	psi-mi:“MI:0914”(association)	0.640
PPP2R3A	WTIP	psi-mi:“MI:0914”(association)	0.640
DNM1	SNX33	psi-mi:“MI:0915”(physical association)	0.640
SNX33	DNM1	psi-mi:“MI:0915”(physical association)	0.640
SNX33	SNX33	psi-mi:“MI:0915”(physical association)	0.590
SNX33	SNX9	psi-mi:“MI:0915”(physical association)	0.590

BioGRID (83): SNX33 (Affinity Capture-MS), SNX33 (Affinity Capture-MS), SNX33 (Affinity Capture-MS), SNX33 (Affinity Capture-MS), SNX33 (Affinity Capture-MS), SNX33 (Affinity Capture-MS), SNX33 (Affinity Capture-MS), SNX33 (Affinity Capture-MS), SNX33 (Affinity Capture-MS), SNX33 (Affinity Capture-MS), SNX33 (Affinity Capture-MS), SNX33 (Affinity Capture-MS), SNX33 (Affinity Capture-MS), SNX33 (Affinity Capture-MS), SNX33 (Affinity Capture-MS)

ESM2 similar proteins: A0A1B7YDZ4, B1H267, I1RXT2, O14243, O60107, O74960, O94447, P0CR58, P0CR59, P0CR62, P0CR63, P0CR64, P0CR65, P32912, P32913, P40531, P40959, P47057, Q09746, Q10253, Q28GP7, Q3ZBM5, Q4PHC3, Q4VAA7, Q4WQI6, Q522W5, Q5B797, Q5R613, Q6C238, Q6C9X0, Q6CGJ5, Q6CHY6, Q6CTQ0, Q6CUC4, Q6FPT9, Q6NRL2, Q6P8X1, Q759T1, Q75B65, Q75C43

Diamond homologs: A1A4L0, O14120, O60107, O60493, O70492, O70493, O94291, O95219, P0C220, P0CR60, P0CR61, P40959, Q04053, Q08DD7, Q1RMH8, Q28GP7, Q2KHV6, Q2U4K2, Q3MPQ4, Q4I1H6, Q4P1V3, Q4PHC3, Q4VAA7, Q4WWS3, Q4WZF1, Q59TN9, Q5A748, Q5AD77, Q5AZC9, Q5R4C2, Q5R5V1, Q5R7A7, Q5R9A9, Q5U211, Q6BIS2, Q6BZE1, Q6C2S9, Q6CHY6, Q6CUC4, Q6CWX3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 80 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Degradation of the extracellular matrix	6	16.1×	3e-04
Extracellular matrix organization	11	15.8×	3e-08

GO biological processes:

GO term	Partners	Fold	FDR
receptor-mediated endocytosis	5	16.1×	2e-03
endocytosis	8	11.0×	2e-04
cell migration	7	6.2×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

86 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	81
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

627 predictions. Top by Δscore:

Variant	Effect	Δscore
15:75657196:GCAT:G	donor_gain	1.0000
15:75657200:G:GG	donor_gain	1.0000
15:75648098:T:G	donor_gain	0.9900
15:75650572:AGG:A	donor_loss	0.9900
15:75650573:GGT:G	donor_loss	0.9900
15:75650575:T:A	donor_loss	0.9900
15:75656956:T:G	acceptor_gain	0.9900
15:75656958:CCA:C	acceptor_loss	0.9900
15:75656960:A:AG	acceptor_gain	0.9900
15:75656961:G:A	acceptor_loss	0.9900
15:75656961:G:GG	acceptor_gain	0.9900
15:75656961:GGC:G	acceptor_gain	0.9900
15:75657197:C:T	donor_gain	0.9900
15:75656955:A:AG	acceptor_gain	0.9800
15:75656956:T:TA	acceptor_gain	0.9800
15:75656960:AGGC:A	acceptor_gain	0.9800
15:75656961:GGCG:G	acceptor_gain	0.9800
15:75656961:GGCGC:G	acceptor_gain	0.9800
15:75648310:T:TA	donor_gain	0.9700
15:75648423:AGT:A	donor_gain	0.9700
15:75656950:T:TA	acceptor_gain	0.9700
15:75648102:GTGT:G	donor_gain	0.9600
15:75648265:G:C	donor_gain	0.9600
15:75656955:AT:A	acceptor_gain	0.9600
15:75647912:G:A	donor_gain	0.9500
15:75648082:T:A	donor_gain	0.9500
15:75648133:GGGTC:G	donor_gain	0.9500
15:75648134:GGTCG:G	donor_gain	0.9500
15:75648335:T:TA	donor_gain	0.9500
15:75650411:G:GC	acceptor_gain	0.9500

AlphaMissense

3859 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:75649133:T:C	F11L	1.000
15:75649135:T:A	F11L	1.000
15:75649135:T:G	F11L	1.000
15:75649214:T:A	W38R	1.000
15:75649214:T:C	W38R	1.000
15:75649248:G:A	G49E	1.000
15:75649658:T:C	F186L	1.000
15:75649660:C:A	F186L	1.000
15:75649660:C:G	F186L	1.000
15:75649769:T:A	W223R	1.000
15:75649769:T:C	W223R	1.000
15:75649771:G:C	W223C	1.000
15:75649771:G:T	W223C	1.000
15:75649826:A:G	K242E	1.000
15:75649828:A:C	K242N	1.000
15:75649828:A:T	K242N	1.000
15:75649830:T:C	F243S	1.000
15:75649841:A:G	K247E	1.000
15:75649842:A:T	K247I	1.000
15:75649843:A:C	K247N	1.000
15:75649843:A:T	K247N	1.000
15:75649847:T:G	Y249D	1.000
15:75649856:T:C	Y252H	1.000
15:75649856:T:G	Y252D	1.000
15:75649898:C:A	R266S	1.000
15:75649898:C:G	R266G	1.000
15:75649901:T:C	Y267H	1.000
15:75649901:T:G	Y267D	1.000
15:75649904:A:G	K268E	1.000
15:75649905:A:T	K268I	1.000

dbSNP variants (sampled 300 via entrez): RS1000117540 (15:75648477 AC>A), RS1000185994 (15:75660997 G>A), RS1000813448 (15:75659719 C>G), RS1001179303 (15:75654209 C>A), RS1001270659 (15:75647419 A>C), RS1001408101 (15:75658055 T>C), RS1001488948 (15:75652264 C>T), RS1001500411 (15:75651895 T>G), RS1001618212 (15:75646294 C>T), RS1001754537 (15:75658504 C>T), RS1002355191 (15:75656885 C>T), RS1002755378 (15:75647774 T>A,C,G), RS1002989227 (15:75646246 T>G), RS1003117886 (15:75652537 G>A), RS1003303485 (15:75657488 C>A,T)

Disease associations

OMIM: gene MIM:619107 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST007876_30	Estimated glomerular filtration rate	3.000000e-25

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression	4
FR900359	increases phosphorylation	1
pirinixic acid	affects binding, increases activity, increases expression	1
manganese chloride	increases abundance, increases expression	1
potassium chromate(VI)	decreases expression	1
coumarin	decreases phosphorylation	1
CGP 52608	increases reaction, affects binding	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	decreases methylation	1
jinfukang	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Caffeine	affects phosphorylation	1
Calcitriol	increases expression, affects cotreatment	1
Cisplatin	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Estradiol	decreases expression	1
Manganese	increases abundance, increases expression	1
Oxygen	increases expression	1
Smoke	decreases expression	1
Testosterone	affects cotreatment, increases expression	1
Tobacco Smoke Pollution	increases expression	1
Urethane	decreases expression	1
Antirheumatic Agents	increases expression	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.