SNX4

Summary

SNX4 (sorting nexin 4, HGNC:11175) is a protein-coding gene on chromosome 3q21.2, encoding Sorting nexin-4 (O95219). Involved in the regulation of endocytosis and in several stages of intracellular trafficking.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene.

Source: NCBI Gene 8723 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 67 total
• MANE Select transcript: NM_003794

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11175
Approved symbol	SNX4
Name	sorting nexin 4
Location	3q21.2
Locus type	gene with protein product
Status	Approved
Aliases	ATG24B
Ensembl gene	ENSG00000114520
Ensembl biotype	protein_coding
OMIM	605931
Entrez	8723

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 13 protein_coding, 2 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined

ENST00000251775, ENST00000465505, ENST00000471751, ENST00000473417, ENST00000482965, ENST00000873370, ENST00000873371, ENST00000873372, ENST00000873373, ENST00000873374, ENST00000873375, ENST00000873376, ENST00000873377, ENST00000873378, ENST00000945404, ENST00000945405, ENST00000945406

RefSeq mRNA: 1 — MANE Select: NM_003794 NM_003794

CCDS: CCDS3032

Canonical transcript exons

ENST00000251775 — 14 exons

Exon	Start	End
ENSE00001246362	125446650	125447826
ENSE00001246368	125520032	125520202
ENSE00003471682	125480247	125480319
ENSE00003478078	125453810	125453955
ENSE00003499630	125489408	125489463
ENSE00003504549	125498059	125498194
ENSE00003514508	125460771	125460860
ENSE00003556431	125457266	125457365
ENSE00003569423	125469454	125469519
ENSE00003583805	125451305	125451419
ENSE00003585862	125497834	125497983
ENSE00003585874	125504623	125504744
ENSE00003657134	125497341	125497388
ENSE00003684216	125476695	125476756

Expression profiles

Bgee: expression breadth ubiquitous, 298 present calls, max score 97.47.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 45.9078 / max 812.6196, expressed in 1823 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
44302	45.6166	1823
44301	0.2912	73

Top tissues by expression

299 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	97.47	gold quality
jejunal mucosa	UBERON:0000399	95.40	gold quality
cortical plate	UBERON:0005343	95.12	gold quality
calcaneal tendon	UBERON:0003701	94.44	gold quality
nephron tubule	UBERON:0001231	94.07	gold quality
tendon	UBERON:0000043	93.80	gold quality
ganglionic eminence	UBERON:0004023	93.47	gold quality
ventricular zone	UBERON:0003053	92.89	gold quality
islet of Langerhans	UBERON:0000006	92.73	gold quality
duodenum	UBERON:0002114	92.67	gold quality
choroid plexus epithelium	UBERON:0003911	92.55	gold quality
tendon of biceps brachii	UBERON:0008188	92.49	gold quality
tibia	UBERON:0000979	92.21	gold quality
pancreatic ductal cell	CL:0002079	92.14	gold quality
rectum	UBERON:0001052	92.04	gold quality
oocyte	CL:0000023	91.69	gold quality
kidney epithelium	UBERON:0004819	91.19	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.11	gold quality
kidney	UBERON:0002113	90.87	gold quality
sperm	CL:0000019	90.84	gold quality
renal glomerulus	UBERON:0000074	90.77	gold quality
corpus callosum	UBERON:0002336	90.71	gold quality
metanephric glomerulus	UBERON:0004736	90.70	gold quality
adult mammalian kidney	UBERON:0000082	90.68	gold quality
jejunum	UBERON:0002115	90.36	gold quality
cortex of kidney	UBERON:0001225	90.29	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	90.26	gold quality
adrenal tissue	UBERON:0018303	90.00	gold quality
medial globus pallidus	UBERON:0002477	89.95	gold quality
liver	UBERON:0002107	89.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.37

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

126 targeting SNX4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-6744-5P	99.93	66.82	748
HSA-MIR-6508-5P	99.92	70.67	2465

Literature-anchored findings (GeneRIF, showing 8)

• Sorting nexin 4 and amphiphysin 2 have roles in endocytosis and intracellular trafficking (PMID:12668730)
• study indicates that hVps34 and its product PI(3)P are involved in endosome to Golgi transport of ricin, and that SNX2 and SNX4 are likely to be effectors in this pathway (PMID:17319803)
• by driving membrane tubulation, SNX4 coordinates iterative, geometric-based sorting of the TfnR with the long-range transport of carriers from early endosomes to the ERC (PMID:17994011)
• clathrin serving as a regulator of SNX4-dependent transport; upon clathrin release, dynein may bind SNX4 and mediate retrograde movement (PMID:19529763)
• SNX4, but not SNX1 and SNX8, is associated with the Rab11-recycling endosomes and that a high frequency of SNX4-mediated tubule formation is observed as endosomes undergo Rab4-to-Rab11 transition. (PMID:21973056)
• alpha-taxilin interacts with SNX4 and plays a role in the recycling pathway of TfnR. (PMID:24690921)
• Results indicate that SNX4-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer’s disease progression. (PMID:28109317)
• The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy. (PMID:33468622)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	snx4	ENSDARG00000022659
mus_musculus	Snx4	ENSMUSG00000022808
rattus_norvegicus	Snx4	ENSRNOG00000001786

Paralogs (15): SNX11 (ENSG00000002919), SNX1 (ENSG00000028528), SNX10 (ENSG00000086300), SNX5 (ENSG00000089006), SNX8 (ENSG00000106266), SNX3 (ENSG00000112335), SNX6 (ENSG00000129515), SNX9 (ENSG00000130340), SNX12 (ENSG00000147164), SNX30 (ENSG00000148158), SNX7 (ENSG00000162627), SNX32 (ENSG00000172803), SNX33 (ENSG00000173548), SNX18 (ENSG00000178996), SNX2 (ENSG00000205302)

Protein

Protein identifiers

Sorting nexin-4 — O95219 (reviewed: O95219)

All UniProt accessions (3): O95219, F8W9T3, F8WDD4

UniProt curated annotations — full annotation on UniProt →

Function. Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A.

Subunit / interactions. Heterodimer; heterodimerizes with SNX7 or SNX30. Interacts with SNX32. Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2. Interacts with BIN1.

Subcellular location. Early endosome membrane.

Domain organisation. The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

Similarity. Belongs to the sorting nexin family.

Isoforms (2)

UniProt ID	Names	Canonical?
O95219-1	1	yes
O95219-2	2

RefSeq proteins (1): NP_003785* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001683	PX_dom	Domain
IPR027267	AH/BAR_dom_sf	Homologous_superfamily
IPR034783	SNX4	Family
IPR034902	PX_SNX4	Domain
IPR036871	PX_dom_sf	Homologous_superfamily
IPR037430	SNX4_BAR	Domain

Pfam: PF00787

UniProt features (11 total): binding site 4, modified residue 2, chain 1, domain 1, mutagenesis site 1, region of interest 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95219-F1	84.73	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 106; 108; 132; 154

Post-translational modifications (2): 1, 22

Mutagenesis-validated functional residues (1):

Position	Phenotype
132	abolishes phosphatidylinositol phosphate binding. abolishes endosomal location.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 251 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, GOBP_REGULATION_OF_AUTOPHAGY, GOBP_VACUOLE_ORGANIZATION, GOBP_INFLAMMATORY_RESPONSE, GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION, GOBP_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION, MORF_BRCA1, MORF_ATRX, GOBP_REGULATION_OF_EXOCYTOSIS, GOBP_REGULATION_OF_HORMONE_LEVELS, GOBP_HORMONE_TRANSPORT, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_REGULATION_OF_VACUOLE_ORGANIZATION, GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS

GO Biological Process (4): protein transport (GO:0015031), endocytic recycling (GO:0032456), positive regulation of histamine secretion by mast cell (GO:1903595), positive regulation of autophagosome assembly (GO:2000786)

GO Molecular Function (8): epidermal growth factor receptor binding (GO:0005154), insulin receptor binding (GO:0005158), phosphatidylinositol-3-phosphate binding (GO:0032266), phosphatidylinositol binding (GO:0035091), transferrin receptor binding (GO:1990459), leptin receptor binding (GO:1990460), protein binding (GO:0005515), lipid binding (GO:0008289)

GO Cellular Component (10): cytoplasm (GO:0005737), early endosome (GO:0005769), cytoplasmic dynein complex (GO:0005868), plasma membrane (GO:0005886), membrane (GO:0016020), SNARE complex (GO:0031201), early endosome membrane (GO:0031901), protein-containing complex (GO:0032991), presynaptic endosome (GO:0098830), endosome (GO:0005768)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
signaling receptor binding	3
binding	2
cellular anatomical structure	2
endosome	2
transport	1
intracellular protein localization	1
establishment of protein localization	1
endosomal transport	1
vesicle-mediated transport to the plasma membrane	1
histamine secretion by mast cell	1
positive regulation of mast cell degranulation	1
positive regulation of hormone secretion	1
positive regulation of inflammatory response	1
positive regulation of multicellular organismal process	1
regulation of histamine secretion by mast cell	1
autophagosome assembly	1
positive regulation of macroautophagy	1
positive regulation of vacuole organization	1
positive regulation of organelle assembly	1
regulation of autophagosome assembly	1
growth factor receptor binding	1
phosphatidylinositol phosphate binding	1
anion binding	1
intracellular anatomical structure	1
dynein complex	1
membrane	1
cell periphery	1
cytoplasm	1
membrane protein complex	1
early endosome	1
endosome membrane	1
cellular_component	1
presynapse	1
endomembrane system	1
cytoplasmic vesicle	1

Protein interactions and networks

STRING

1702 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SNX4	SNX1	Q13596	976
SNX4	SNX6	Q9UNH7	910
SNX4	SERPINE2	P07093	893
SNX4	SNX5	Q9Y5X3	845
SNX4	WWC1	Q8IX03	831
SNX4	SNX15	Q9NRS6	803
SNX4	LEPR	P48357	791
SNX4	VPS35	Q96QK1	764
SNX4	VPS26A	O75436	762
SNX4	VPS29	Q9UBQ0	753
SNX4	SNX7	Q9UNH6	739
SNX4	SNX17	Q15036	720
SNX4	IFT122	Q9HBG6	706
SNX4	SNX3	O60493	694
SNX4	TFRC	P02786	658

IntAct

81 interactions, top by confidence:

A	B	Type	Score
SNX4	SNX30	psi-mi:“MI:0914”(association)	0.830
SNX4	SNX30	psi-mi:“MI:0915”(physical association)	0.830
CFTR	XPO1	psi-mi:“MI:0914”(association)	0.710
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
SNX7	SNX4	psi-mi:“MI:0914”(association)	0.670
SNX4	SNX7	psi-mi:“MI:0915”(physical association)	0.670
SNX7	SNX4	psi-mi:“MI:0915”(physical association)	0.670
BIN1	SNX4	psi-mi:“MI:0915”(physical association)	0.630
SNX4	BIN1	psi-mi:“MI:0915”(physical association)	0.630
MAGEA6	SNX4	psi-mi:“MI:0915”(physical association)	0.560
ARL6IP1	SNX4	psi-mi:“MI:0915”(physical association)	0.560
SNX4	MAGEA6	psi-mi:“MI:0915”(physical association)	0.560
SNX4	SH3GLB1	psi-mi:“MI:0915”(physical association)	0.560
SNX4	DGAT2L6	psi-mi:“MI:0915”(physical association)	0.560
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
SNX4	Bin1	psi-mi:“MI:0915”(physical association)	0.460
Bin1	SNX4	psi-mi:“MI:0403”(colocalization)	0.460

BioGRID (88): SNX4 (Two-hybrid), ARL6IP1 (Two-hybrid), SNX4 (Affinity Capture-MS), SNX4 (Proximity Label-MS), SNX4 (Two-hybrid), SNX4 (Proximity Label-MS), SNX30 (Affinity Capture-MS), SNX4 (Affinity Capture-MS), ANKMY2 (Affinity Capture-MS), ABCB10 (Affinity Capture-MS), CACYBP (Affinity Capture-MS), SNX4 (Affinity Capture-MS), SNX4 (Proximity Label-MS), SNX4 (Affinity Capture-Western), SNX4 (Proximity Label-MS)

ESM2 similar proteins: A0A098DRQ4, A1A4L0, A1CAN8, A1DF15, A1L1C7, A6RJQ7, A7E559, A7KAL4, B2AVN3, C8VDI2, C8VDQ4, I1RKA1, I1S4N7, O60749, O95219, P0C220, P83094, Q0WQF4, Q2TBW7, Q2U7R4, Q2UB56, Q4IR87, Q4WCV3, Q4WUE5, Q4WZF1, Q524W4, Q5AZC9, Q5R4C2, Q5R6M6, Q5R9A9, Q6NRZ4, Q6P3Q6, Q6PCS4, Q6VVX2, Q7SB54, Q7SB97, Q8J2R3, Q8K3H0, Q8VWF1, Q91VH2

Diamond homologs: A1A4L0, O14120, O60107, O60493, O70492, O70493, O94291, O95219, P0C220, P0CR60, P0CR61, P40959, Q04053, Q08DD7, Q1RMH8, Q28GP7, Q2KHV6, Q2U4K2, Q3MPQ4, Q4I1H6, Q4P1V3, Q4PHC3, Q4VAA7, Q4WWS3, Q4WZF1, Q59TN9, Q5A748, Q5AD77, Q5AZC9, Q5R4C2, Q5R5V1, Q5R7A7, Q5R9A9, Q5U211, Q6BIS2, Q6BZE1, Q6C2S9, Q6CHY6, Q6CUC4, Q6CWX3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 59 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Clathrin-mediated endocytosis	6	15.5×	4e-04

GO biological processes:

GO term	Partners	Fold	FDR
endocytosis	7	13.9×	2e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2736 predictions. Top by Δscore:

Variant	Effect	Δscore
3:125451301:CTA:C	donor_loss	1.0000
3:125451302:TAC:T	donor_loss	1.0000
3:125451304:CCTT:C	donor_loss	1.0000
3:125451317:A:AC	donor_gain	1.0000
3:125451318:C:CC	donor_gain	1.0000
3:125451318:CTGAT:C	donor_gain	1.0000
3:125451322:T:C	donor_gain	1.0000
3:125451338:G:C	donor_gain	1.0000
3:125451351:T:TA	donor_gain	1.0000
3:125451415:ATTCT:A	acceptor_gain	1.0000
3:125451416:TTCT:T	acceptor_gain	1.0000
3:125451417:TCTC:T	acceptor_loss	1.0000
3:125451418:CT:C	acceptor_gain	1.0000
3:125451420:C:CC	acceptor_gain	1.0000
3:125451421:T:A	acceptor_loss	1.0000
3:125451425:A:AC	acceptor_gain	1.0000
3:125453835:G:C	donor_gain	1.0000
3:125453951:ACAGT:A	acceptor_gain	1.0000
3:125453952:CAGT:C	acceptor_gain	1.0000
3:125453952:CAGTC:C	acceptor_gain	1.0000
3:125453953:AGT:A	acceptor_gain	1.0000
3:125453954:GT:G	acceptor_gain	1.0000
3:125453955:TCTA:T	acceptor_loss	1.0000
3:125453956:C:CC	acceptor_gain	1.0000
3:125453956:C:CG	acceptor_loss	1.0000
3:125457264:AC:A	donor_gain	1.0000
3:125457264:ACC:A	donor_gain	1.0000
3:125457265:CC:C	donor_gain	1.0000
3:125457265:CCC:C	donor_gain	1.0000
3:125457361:CAGCC:C	acceptor_gain	1.0000

AlphaMissense

2974 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:125447814:A:G	W440R	1.000
3:125447814:A:T	W440R	1.000
3:125469469:C:T	G280D	1.000
3:125469515:A:G	W265R	1.000
3:125469515:A:T	W265R	1.000
3:125476707:C:T	G259D	1.000
3:125497898:A:G	L162P	1.000
3:125497910:A:G	L158S	1.000
3:125497919:C:G	R155P	1.000
3:125497922:C:G	R154P	1.000
3:125497933:A:C	F150L	1.000
3:125497933:A:T	F150L	1.000
3:125497935:A:G	F150L	1.000
3:125498144:C:G	R105P	1.000
3:125447812:C:A	W440C	0.999
3:125447812:C:G	W440C	0.999
3:125451345:A:G	L422P	0.999
3:125451403:C:G	A403P	0.999
3:125469458:C:G	D284H	0.999
3:125469469:C:A	G280V	0.999
3:125469470:C:G	G280R	0.999
3:125469472:G:T	A279D	0.999
3:125469473:C:G	A279P	0.999
3:125469481:A:G	L276P	0.999
3:125469510:A:C	S266R	0.999
3:125469510:A:T	S266R	0.999
3:125469512:T:G	S266R	0.999
3:125476707:C:A	G259V	0.999
3:125476708:C:G	G259R	0.999
3:125497379:A:G	W187R	0.999

dbSNP variants (sampled 300 via entrez): RS1000007594 (3:125470307 G>A,C,T), RS1000016362 (3:125513332 T>C), RS1000140477 (3:125475766 CAGG>C), RS1000189888 (3:125495746 G>A), RS1000190564 (3:125500034 T>A,C), RS1000257967 (3:125489258 A>G), RS1000294448 (3:125446608 T>G), RS1000343129 (3:125477425 A>G), RS1000363178 (3:125483612 C>T), RS1000415766 (3:125483934 G>A), RS1000492532 (3:125513664 T>A,C), RS1000520487 (3:125451623 A>G), RS1000525074 (3:125510820 A>G), RS1000581292 (3:125491394 G>A,C,T), RS1000588508 (3:125452823 T>C)

Disease associations

OMIM: gene MIM:605931 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST008745_39	Estimated glomerular filtration rate in non-diabetics	3.000000e-08
GCST008972_34	Urate levels	4.000000e-10
GCST010988_112	Adult body size	4.000000e-08
GCST012305_5	Major depressive disorder x sex interaction	3.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement
EFO:0008343	sex interaction measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases abundance, increases expression, affects methylation, decreases expression, affects cotreatment	3
perfluorooctane sulfonic acid	decreases expression, increases expression	3
bisphenol A	decreases expression	2
Air Pollutants	increases oxidation, decreases expression, affects cotreatment, increases abundance	2
FR900359	decreases phosphorylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
cobaltous chloride	increases expression	1
perfluorooctanoic acid	increases expression	1
manganese chloride	increases expression, affects cotreatment, increases abundance	1
potassium chromate(VI)	decreases expression, affects cotreatment	1
methacrylaldehyde	increases abundance, affects cotreatment, increases oxidation	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
trovafloxacin	affects cotreatment, decreases expression	1
CGP 52608	affects binding, increases reaction	1
monomethylarsonous acid	increases expression	1
perfluorohexanesulfonic acid	decreases expression	1
jinfukang	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Acetaminophen	decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Arsenic	increases abundance, increases expression, affects cotreatment	1
Atrazine	decreases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Demecolcine	decreases expression	1
Formaldehyde	decreases expression	1
Ivermectin	decreases expression	1
Lipopolysaccharides	affects expression, affects response to substance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.