SNX8

Summary

SNX8 (sorting nexin 8, HGNC:14972) is a protein-coding gene on chromosome 7p22.3, encoding Sorting nexin-8 (Q9Y5X2). May be involved in several stages of intracellular trafficking.

Enables identical protein binding activity and phosphatidylinositol binding activity. Involved in early endosome to Golgi transport and intracellular protein transport. Located in early endosome membrane and retromer complex.

Source: NCBI Gene 29886 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 113 total
• MANE Select transcript: NM_013321

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14972
Approved symbol	SNX8
Name	sorting nexin 8
Location	7p22.3
Locus type	gene with protein product
Status	Approved
Aliases	Mvp1
Ensembl gene	ENSG00000106266
Ensembl biotype	protein_coding
OMIM	614905
Entrez	29886

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 10 protein_coding, 3 retained_intron

ENST00000222990, ENST00000419693, ENST00000435060, ENST00000435336, ENST00000447136, ENST00000457286, ENST00000479689, ENST00000480807, ENST00000494722, ENST00000878403, ENST00000878404, ENST00000926983, ENST00000926984

RefSeq mRNA: 1 — MANE Select: NM_013321 NM_013321

CCDS: CCDS5331

Canonical transcript exons

ENST00000222990 — 11 exons

Exon	Start	End
ENSE00000668098	2275112	2275229
ENSE00000668099	2271850	2271971
ENSE00000668103	2257735	2257803
ENSE00000668104	2257365	2257514
ENSE00000831511	2314328	2314441
ENSE00001156125	2251770	2255169
ENSE00003496078	2256874	2257023
ENSE00003568471	2263230	2263362
ENSE00003574835	2264298	2264458
ENSE00003578352	2269559	2269639
ENSE00003667250	2278100	2278305

Expression profiles

Bgee: expression breadth ubiquitous, 187 present calls, max score 94.76.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 21.2744 / max 239.8270, expressed in 1808 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
82485	18.9459	1806
82487	2.1058	1078
82486	0.2085	76
82483	0.0080	2
82482	0.0062	4

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	94.76	gold quality
left testis	UBERON:0004533	93.72	gold quality
right testis	UBERON:0004534	92.92	gold quality
spleen	UBERON:0002106	92.67	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.28	gold quality
testis	UBERON:0000473	91.15	gold quality
vermiform appendix	UBERON:0001154	90.43	gold quality
lymph node	UBERON:0000029	89.88	gold quality
tendon of biceps brachii	UBERON:0008188	89.69	gold quality
gall bladder	UBERON:0002110	88.57	gold quality
prefrontal cortex	UBERON:0000451	87.78	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.65	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.55	gold quality
subcutaneous adipose tissue	UBERON:0002190	87.51	gold quality
hindlimb stylopod muscle	UBERON:0004252	87.28	gold quality
right atrium auricular region	UBERON:0006631	87.22	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	87.02	gold quality
granulocyte	CL:0000094	86.80	gold quality
cerebellar vermis	UBERON:0004720	86.80	silver quality
upper lobe of left lung	UBERON:0008952	86.79	gold quality
omental fat pad	UBERON:0010414	86.78	gold quality
skin of leg	UBERON:0001511	86.76	gold quality
caecum	UBERON:0001153	86.74	gold quality
peritoneum	UBERON:0002358	86.74	gold quality
amniotic fluid	UBERON:0000173	86.73	gold quality
lower esophagus mucosa	UBERON:0035834	86.30	gold quality
spinal cord	UBERON:0002240	85.98	gold quality
adipose tissue of abdominal region	UBERON:0007808	85.93	gold quality
cardiac atrium	UBERON:0002081	85.87	gold quality
upper lobe of lung	UBERON:0008948	85.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	12.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

126 targeting SNX8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-22-3P	99.93	68.13	917
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-302A-3P	99.89	71.23	1777
HSA-MIR-302B-3P	99.89	71.23	1777
HSA-MIR-302C-3P	99.89	71.20	1778
HSA-MIR-302D-3P	99.89	71.25	1777
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-20B-5P	99.88	74.01	2621
HSA-MIR-519D-3P	99.88	73.97	2607

Literature-anchored findings (GeneRIF, showing 6)

• SNX4, but not SNX1 and SNX8, is associated with the Rab11-recycling endosomes and that a high frequency of SNX4-mediated tubule formation is observed as endosomes undergo Rab4-to-Rab11 transition. (PMID:21973056)
• SNX8: A candidate gene for 7p22 cardiac malformations including tetralogy of fallot. (PMID:24311514)
• SNX8 mediates IFNG-triggered non-canonical signaling pathway and host defense against Listeria monocytogenes. (PMID:29180417)
• Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD. (PMID:34231239)
• A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling. (PMID:34524084)
• SNX8 enables lysosome reformation and reverses lysosomal storage disorder. (PMID:38519472)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	snx8a	ENSDARG00000074842
danio_rerio	snx8b	ENSDARG00000078057
mus_musculus	Snx8	ENSMUSG00000029560
rattus_norvegicus	Snx8	ENSRNOG00000001258

Paralogs (15): SNX11 (ENSG00000002919), SNX1 (ENSG00000028528), SNX10 (ENSG00000086300), SNX5 (ENSG00000089006), SNX3 (ENSG00000112335), SNX4 (ENSG00000114520), SNX6 (ENSG00000129515), SNX9 (ENSG00000130340), SNX12 (ENSG00000147164), SNX30 (ENSG00000148158), SNX7 (ENSG00000162627), SNX32 (ENSG00000172803), SNX33 (ENSG00000173548), SNX18 (ENSG00000178996), SNX2 (ENSG00000205302)

Protein

Protein identifiers

Sorting nexin-8 — Q9Y5X2 (reviewed: Q9Y5X2)

All UniProt accessions (6): Q9Y5X2, C9IYC5, C9J014, C9J271, C9J8E6, C9JCB9

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.

Subcellular location. Early endosome membrane.

Similarity. Belongs to the sorting nexin family.

RefSeq proteins (1): NP_037453* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001683	PX_dom	Domain
IPR027267	AH/BAR_dom_sf	Homologous_superfamily
IPR028662	SNX8/Mvp1	Family
IPR035704	SNX8/Mvp1_PX	Domain
IPR036871	PX_dom_sf	Homologous_superfamily
IPR045734	Snx8_BAR_dom	Domain

Pfam: PF00787, PF19566

UniProt features (10 total): binding site 3, modified residue 2, chain 1, domain 1, region of interest 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y5X2-F1	84.36	0.68

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (3): 109; 135; 148

Post-translational modifications (2): 452, 456

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 193 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_UP, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, KYNG_DNA_DAMAGE_DN, GOBP_VESICLE_MEDIATED_TRANSPORT, chr7p22, GOBP_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT, USF_02, GOBP_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI, MODULE_48, NIKOLSKY_BREAST_CANCER_7P22_AMPLICON, IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP, MODULE_95, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, SENESE_HDAC3_TARGETS_DN, GOBP_CYTOSOLIC_TRANSPORT

GO Biological Process (4): intracellular protein transport (GO:0006886), early endosome to Golgi transport (GO:0034498), protein transport (GO:0015031), retrograde transport, endosome to Golgi (GO:0042147)

GO Molecular Function (4): phosphatidylinositol binding (GO:0035091), identical protein binding (GO:0042802), protein binding (GO:0005515), lipid binding (GO:0008289)

GO Cellular Component (6): cytosol (GO:0005829), early endosome membrane (GO:0031901), endosome (GO:0005768), membrane (GO:0016020), retromer complex (GO:0030904), cytoplasmic vesicle (GO:0031410)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular protein localization	2
binding	2
cytoplasm	2
cellular anatomical structure	2
endomembrane system	2
protein transport	1
intracellular transport	1
retrograde transport, endosome to Golgi	1
Golgi vesicle transport	1
transport	1
establishment of protein localization	1
intercellular transport	1
endosomal transport	1
cytosolic transport	1
anion binding	1
protein binding	1
early endosome	1
endosome membrane	1
cytoplasmic vesicle	1
membrane protein complex	1
intracellular vesicle	1

Protein interactions and networks

STRING

962 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SNX8	SNX3	O60493	794
SNX8	SNX1	Q13596	754
SNX8	PIK3C3	Q8NEB9	683
SNX8	VPS35	Q96QK1	666
SNX8	SNX5	Q9Y5X3	651
SNX8	SNX32	Q86XE0	643
SNX8	SNX6	Q9UNH7	623
SNX8	DCHS1	Q96JQ0	616
SNX8	SNX12	Q9UMY4	607
SNX8	VPS26A	O75436	547
SNX8	SNX15	Q9NRS6	543
SNX8	SNX4	O95219	542
SNX8	VPS29	Q9UBQ0	535
SNX8	SNX17	Q15036	533
SNX8	SNX27	Q96L92	527

IntAct

56 interactions, top by confidence:

A	B	Type	Score
POLR3GL	POLR3A	psi-mi:“MI:0914”(association)	0.730
SNX8	POR	psi-mi:“MI:0914”(association)	0.640
GYPA	TCAF2	psi-mi:“MI:0914”(association)	0.640
REEP6	SNX8	psi-mi:“MI:0915”(physical association)	0.560
RABAC1	SNX8	psi-mi:“MI:0915”(physical association)	0.560
ARL6IP1	SNX8	psi-mi:“MI:0915”(physical association)	0.560
C14orf119	SNX8	psi-mi:“MI:0915”(physical association)	0.560
AKT3	HSP90AA1	psi-mi:“MI:0914”(association)	0.560
RXRG	NR2F6	psi-mi:“MI:0914”(association)	0.530
CFP	B3GLCT	psi-mi:“MI:0914”(association)	0.530
NFIL3	STK40	psi-mi:“MI:0914”(association)	0.530
WLS	CHRNB1	psi-mi:“MI:0914”(association)	0.530
BSG	BTAF1	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
Dlg4	SNX8	psi-mi:“MI:0407”(direct interaction)	0.440
ABL1	SNX8	psi-mi:“MI:0915”(physical association)	0.400
FYN	SNX8	psi-mi:“MI:0915”(physical association)	0.400
SNX8	GRB2	psi-mi:“MI:0915”(physical association)	0.400
SNX8	NCK1	psi-mi:“MI:0915”(physical association)	0.400
SNX8	PIK3R1	psi-mi:“MI:0915”(physical association)	0.400
SNX8	MYDGF	psi-mi:“MI:0915”(physical association)	0.400
SNX8	MAVS	psi-mi:“MI:0915”(physical association)	0.400
SNX8	SNX8	psi-mi:“MI:0915”(physical association)	0.400
SNX9	SNX8	psi-mi:“MI:0915”(physical association)	0.400
SNX18	SNX8	psi-mi:“MI:0915”(physical association)	0.400
SNX33	SNX8	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (55): SNX8 (Affinity Capture-RNA), SNX8 (Affinity Capture-RNA), SNX8 (Affinity Capture-RNA), MSH3 (Co-fractionation), SNX8 (Co-fractionation), SNX8 (Affinity Capture-MS), FBXW7 (Affinity Capture-MS), POR (Affinity Capture-MS), RUFY1 (Affinity Capture-MS), SNX8 (Affinity Capture-MS), LACC1 (Affinity Capture-MS), SNX8 (Affinity Capture-MS), SNX8 (Affinity Capture-MS), SNX8 (Two-hybrid), REEP6 (Two-hybrid)

ESM2 similar proteins: A5PK26, F8VPU2, O14526, O14976, O15068, O75064, O94887, P00530, P97874, P98150, P98171, Q00653, Q15027, Q15149, Q2HJE1, Q2KHV6, Q3TBD2, Q3U1Y4, Q4LDD4, Q5FVC7, Q5RB40, Q5RC07, Q5U464, Q5ZK62, Q61210, Q64096, Q6DE55, Q6IVG4, Q6P730, Q6ZQK5, Q6ZSZ5, Q8CFD4, Q8K285, Q8K2H4, Q8R5G7, Q8TDY4, Q8WWN8, Q91VS8, Q91ZR2, Q92619

Diamond homologs: A0A1B7YDZ4, I1RXT2, O14243, O60107, O60493, O70492, O70493, P0CR58, P0CR59, P0CR60, P0CR61, P0CR62, P0CR63, P40959, P47057, Q08826, Q08DD7, Q1RMH8, Q2U4K2, Q2UB56, Q3MPQ4, Q4I1H6, Q4P1V3, Q4PHC3, Q4WQI6, Q4WWS3, Q4WZF1, Q522W5, Q5A748, Q5B797, Q5H7C3, Q5R5V1, Q5U211, Q6C2S9, Q6CTQ0, Q6CUC4, Q6FNH2, Q6FPT9, Q6FT03, Q75C43

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
JAK1	“up-regulates activity”	SNX8	phosphorylation
SNX8	“up-regulates activity”	IKBKB	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 62 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
VEGFA-VEGFR2 Pathway	5	16.6×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

113 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	93
Likely benign	5
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

2649 predictions. Top by Δscore:

Variant	Effect	Δscore
7:2256869:CTCA:C	donor_loss	1.0000
7:2256870:TCA:T	donor_loss	1.0000
7:2256871:CACCT:C	donor_loss	1.0000
7:2256872:A:AC	donor_gain	1.0000
7:2256872:ACCT:A	donor_gain	1.0000
7:2256872:ACCTC:A	donor_gain	1.0000
7:2256873:C:CC	donor_gain	1.0000
7:2256873:C:CG	donor_loss	1.0000
7:2256873:CCT:C	donor_gain	1.0000
7:2256873:CCTC:C	donor_gain	1.0000
7:2256873:CCTCC:C	donor_gain	1.0000
7:2256875:T:TA	donor_gain	1.0000
7:2257021:CTG:C	acceptor_gain	1.0000
7:2257024:C:CC	acceptor_gain	1.0000
7:2257730:CTCA:C	donor_loss	1.0000
7:2257731:TCA:T	donor_loss	1.0000
7:2257732:CA:C	donor_loss	1.0000
7:2257733:ACCTT:A	donor_loss	1.0000
7:2264294:CTAC:C	donor_loss	1.0000
7:2264295:TA:T	donor_loss	1.0000
7:2264296:A:AC	donor_gain	1.0000
7:2264296:ACC:A	donor_loss	1.0000
7:2264297:C:CC	donor_gain	1.0000
7:2264463:CATCA:C	acceptor_gain	1.0000
7:2264466:C:CT	acceptor_gain	1.0000
7:2264467:A:AC	acceptor_gain	1.0000
7:2264467:A:C	acceptor_gain	1.0000
7:2264467:A:T	acceptor_gain	1.0000
7:2264470:A:AC	acceptor_gain	1.0000
7:2264470:A:C	acceptor_gain	1.0000

AlphaMissense

3053 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:2271947:C:A	R148M	1.000
7:2275206:T:A	R108S	1.000
7:2275206:T:G	R108S	1.000
7:2275207:C:G	R108T	1.000
7:2257510:A:G	L330P	0.999
7:2271947:C:G	R148T	0.999
7:2275125:C:A	K135N	0.999
7:2275125:C:G	K135N	0.999
7:2275191:G:C	F113L	0.999
7:2275191:G:T	F113L	0.999
7:2275192:A:G	F113S	0.999
7:2275193:A:G	F113L	0.999
7:2275202:A:C	Y110D	0.999
7:2275207:C:A	R108I	0.999
7:2278117:A:G	Y95H	0.999
7:2278126:G:C	H92D	0.999
7:2271935:A:G	L152P	0.998
7:2271946:C:A	R148S	0.998
7:2271946:C:G	R148S	0.998
7:2275127:T:C	K135E	0.998
7:2275150:C:G	R127P	0.998
7:2275195:T:C	D112G	0.998
7:2275202:A:G	Y110H	0.998
7:2275208:T:C	R108G	0.998
7:2278124:A:C	H92Q	0.998
7:2278124:A:T	H92Q	0.998
7:2278134:A:G	F89S	0.998
7:2255157:A:G	W433R	0.997
7:2255157:A:T	W433R	0.997
7:2257501:C:G	R333P	0.997

dbSNP variants (sampled 300 via entrez): RS1000000608 (7:2261182 C>A,T), RS1000025529 (7:2303111 G>A,C,T), RS1000026037 (7:2317303 G>A,C,T), RS1000043891 (7:2334328 G>A), RS1000051263 (7:2261337 G>T), RS1000056511 (7:2302909 C>T), RS1000111110 (7:2324511 G>A), RS1000124580 (7:2330567 A>G), RS1000140057 (7:2335793 A>G), RS1000155480 (7:2330804 TC>T), RS1000186507 (7:2264292 A>G,T), RS1000193484 (7:2320676 A>G), RS1000223243 (7:2320427 T>C,G), RS1000230223 (7:2295858 T>C), RS1000290544 (7:2286070 G>A)

Disease associations

OMIM: gene MIM:614905 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST001565_9	Schizophrenia	2.000000e-09
GCST002149_3	Schizophrenia	6.000000e-13
GCST004521_264	Autism spectrum disorder or schizophrenia	7.000000e-16
GCST005759_5	Dimensional psychopathology (Social)	2.000000e-07
GCST005934_1	Neuropathic pain in head and neck cancer	3.000000e-14
GCST006612_114	LDL cholesterol	1.000000e-08
GCST010653_13	Thyroid stimulating hormone levels	8.000000e-09
GCST90002395_496	Mean platelet volume	2.000000e-12
GCST90002403_192	Red blood cell count	3.000000e-09

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0009100	social domain measurement
EFO:0005762	neuropathic pain
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0004305	erythrocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

50 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation, affects expression, increases expression	3
bisphenol A	decreases expression, decreases methylation	2
Nickel	increases expression	2
Cyclosporine	increases expression	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
2,4,6-tribromophenol	increases expression	1
alpha-pinene	increases abundance, affects cotreatment, increases expression	1
2,5,2’,5’-tetrachlorobiphenyl	increases expression	1
decabromobiphenyl ether	increases expression	1
sodium arsenite	increases expression	1
butyraldehyde	increases expression	1
tetrabromobisphenol A	increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
aflatoxin B2	increases methylation	1
cupric oxide	increases expression	1
methacrylaldehyde	increases abundance, affects cotreatment, increases expression	1
isobutyl alcohol	affects cotreatment, decreases expression, increases abundance	1
epigallocatechin gallate	decreases expression, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
ICG 001	decreases expression	1
abrine	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	increases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Fulvestrant	increases methylation	1
Acrolein	affects cotreatment, increases expression, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.