SOCS2-AS1

Summary

SOCS2-AS1 (SOCS2 antisense RNA 1, HGNC:27054) is a long non-coding RNA gene on chromosome 12q22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27054
Approved symbol	SOCS2-AS1
Name	SOCS2 antisense RNA 1
Location	12q22
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246985
Ensembl biotype	lncRNA
OMIM	617269
Entrez	144481
RNAcentral	URS000075B390 — lncRNA, 574 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 13 lncRNA, 1 retained_intron

ENST00000499137, ENST00000500986, ENST00000547845, ENST00000551626, ENST00000662875, ENST00000668485, ENST00000754694, ENST00000754695, ENST00000754696, ENST00000754697, ENST00000754698, ENST00000754699, ENST00000754700, ENST00000754701

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499137 — 3 exons

Exon	Start	End
ENSE00001969467	93542463	93545358
ENSE00001976615	93571567	93571768
ENSE00001991255	93566744	93566970

Expression profiles

Bgee: expression breadth ubiquitous, 171 present calls, max score 88.28.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.1408 / max 269.2339, expressed in 915 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
132666	1.5187	623
132663	0.7653	248
132665	0.5425	229
132664	0.3143	152

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endocervix	UBERON:0000458	88.28	gold quality
prostate gland	UBERON:0002367	88.15	gold quality
body of uterus	UBERON:0009853	87.65	gold quality
ectocervix	UBERON:0012249	86.19	gold quality
pituitary gland	UBERON:0000007	84.78	gold quality
myometrium	UBERON:0001296	84.24	gold quality
uterine cervix	UBERON:0000002	84.19	gold quality
adenohypophysis	UBERON:0002196	83.99	gold quality
smooth muscle tissue	UBERON:0001135	82.72	gold quality
muscle layer of sigmoid colon	UBERON:0035805	79.03	gold quality
uterus	UBERON:0000995	77.50	gold quality
left uterine tube	UBERON:0001303	77.36	gold quality
vagina	UBERON:0000996	77.00	gold quality
stromal cell of endometrium	CL:0002255	76.09	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.95	silver quality
omental fat pad	UBERON:0010414	75.91	gold quality
peritoneum	UBERON:0002358	75.84	gold quality
islet of Langerhans	UBERON:0000006	75.74	gold quality
descending thoracic aorta	UBERON:0002345	75.48	gold quality
body of stomach	UBERON:0001161	74.31	gold quality
adipose tissue of abdominal region	UBERON:0007808	74.15	gold quality
ascending aorta	UBERON:0001496	73.92	gold quality
thoracic aorta	UBERON:0001515	73.79	gold quality
left coronary artery	UBERON:0001626	73.01	gold quality
upper lobe of left lung	UBERON:0008952	72.95	gold quality
lower esophagus mucosa	UBERON:0035834	72.94	gold quality
left lobe of thyroid gland	UBERON:0001120	72.44	gold quality
mucosa of stomach	UBERON:0001199	72.03	gold quality
upper lobe of lung	UBERON:0008948	71.97	gold quality
female reproductive system	UBERON:0000474	71.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.97

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• SOCS2-AS1 promotes androgen signaling by modulating the epigenetic control for AR target genes including TNFSF10 (PMID:27342777)
• Circulating Exosomal SOCS2-AS1 Acts as a Novel Biomarker in Predicting the Diagnosis of Coronary Artery Disease. (PMID:32352013)
• LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264. (PMID:32437330)
• Kawasaki disease: SOCS2-AS1/miR-324-5p/CUEDC2 axis regulates the progression of human umbilical vein endothelial cells. (PMID:32688371)
• LncRNA SOCS2-AS1 promotes the progression of glioma via regulating ITGB1 expression. (PMID:34536509)
• LncRNA SOCS2-AS1 promotes the progression of papillary thyroid cancer by destabilizing p53 protein. (PMID:37267865)
• YY1-regulated lncRNA SOCS2-AS1 suppresses HCC cell stemness and progression via miR-454-3p/CPEB1. (PMID:37677983)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.