SOCS7

Summary

SOCS7 (suppressor of cytokine signaling 7, HGNC:29846) is a protein-coding gene on chromosome 17q12, encoding Suppressor of cytokine signaling 7 (O14512). Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1.

Predicted to enable phosphorylation-dependent protein binding activity; signaling adaptor activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in insulin receptor signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of neuron migration. Predicted to act upstream of or within brain development; fat cell differentiation; and protein ubiquitination. Located in cytosol. Is active in cytoplasm.

Source: NCBI Gene 30837 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 80 total
• MANE Select transcript: NM_014598

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29846
Approved symbol	SOCS7
Name	suppressor of cytokine signaling 7
Location	17q12
Locus type	gene with protein product
Status	Approved
Aliases	NAP4, NCKAP4
Ensembl gene	ENSG00000274211
Ensembl biotype	protein_coding
OMIM	608788
Entrez	30837

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 4 protein_coding, 1 retained_intron

ENST00000612932, ENST00000613678, ENST00000617360, ENST00000617765, ENST00000665913

RefSeq mRNA: 1 — MANE Select: NM_014598 NM_014598

CCDS: CCDS32637

Canonical transcript exons

ENST00000612932 — 10 exons

Exon	Start	End
ENSE00003717020	38361711	38361775
ENSE00003721567	38351844	38353032
ENSE00003727133	38365308	38365409
ENSE00003728855	38395309	38395444
ENSE00003731046	38367882	38368050
ENSE00003732324	38377714	38377842
ENSE00003736077	38366287	38366417
ENSE00003744753	38364752	38364856
ENSE00003750230	38395848	38395998
ENSE00003752440	38399513	38405593

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 94.71.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.6314 / max 119.7794, expressed in 1663 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
160477	2.5933	1122
160476	2.4832	1229
160481	0.7103	470
160480	0.4301	210
160478	0.2165	75
160479	0.1423	33
208165	0.0556	14

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	94.71	gold quality
left testis	UBERON:0004533	94.67	gold quality
testis	UBERON:0000473	93.39	gold quality
cortical plate	UBERON:0005343	91.89	gold quality
cerebellum	UBERON:0002037	91.65	gold quality
cerebellar cortex	UBERON:0002129	91.58	gold quality
cerebellar hemisphere	UBERON:0002245	91.51	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.29	gold quality
ganglionic eminence	UBERON:0004023	88.88	gold quality
sural nerve	UBERON:0015488	86.83	gold quality
islet of Langerhans	UBERON:0000006	86.74	gold quality
skeletal muscle tissue	UBERON:0001134	85.04	gold quality
superior frontal gyrus	UBERON:0002661	84.37	gold quality
prefrontal cortex	UBERON:0000451	84.17	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.86	gold quality
pancreas	UBERON:0001264	83.81	gold quality
gastrocnemius	UBERON:0001388	83.58	gold quality
muscle of leg	UBERON:0001383	83.48	gold quality
ventricular zone	UBERON:0003053	83.10	gold quality
frontal cortex	UBERON:0001870	82.70	gold quality
adrenal tissue	UBERON:0018303	82.17	gold quality
body of pancreas	UBERON:0001150	81.75	gold quality
muscle tissue	UBERON:0002385	81.74	gold quality
cerebral cortex	UBERON:0000956	81.73	gold quality
anterior cingulate cortex	UBERON:0009835	81.51	gold quality
brain	UBERON:0000955	81.46	gold quality
hindlimb stylopod muscle	UBERON:0004252	81.40	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	81.06	gold quality
colonic epithelium	UBERON:0000397	80.96	gold quality
primary visual cortex	UBERON:0002436	80.43	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ENAD-17	no	259.15
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

235 targeting SOCS7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-4534	99.99	66.58	1907
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788

Literature-anchored findings (GeneRIF, showing 17)

• Taken together, our data indicate that SOCS-7 interacts with vinexin and the actin cytoskeleton. (PMID:15242778)
• Results indicate that SOCS-7 is a dysregulator of prolactin, leptin, and growth hormone signaling and that its mode of action is a variation of SOCS protein inhibition of cytokine-inducible STAT3 and 5-mediated signal transduction. (PMID:15677474)
• data suggest that SOCS7 is a potent regulator of glucose homeostasis and insulin signaling (PMID:16127460)
• Demonstrate connection between septins/SOCS7/NCK signaling and the DNA damage response. (PMID:17803907)
• findings show that PPAR-gamma is involved in the regulation of SOCS-7 expression by hepatitis C virus core protein genotype 3a (PMID:20357037)
• Higher mRNA expression levels of SOCS1, 3, 4 and 7 are significantly associated with earlier tumour stage and better clinical outcome in human breast cancer. (PMID:20433750)
• LNCaP-S17 cells are resistant to exogenous IL-6-induced neuroendocrine differentiation due to increased levels of CIS/SOCS7 that block activation of JAK2-STAT3 pathways. (PMID:22213096)
• The present report describes for the first time associations between common variants in SOCS7 gene and obesity, central obesity, insulin resistance and disorders of lipid metabolism in nondiabetic men from Argentina. (PMID:22397880)
• SOCS7 functioned as an oncogene, the finding that revealed a novel mechanism of carcinogenesis in bladder cancer cells. (PMID:23392170)
• genetic variants in the SOCS7 gene do not impact variation in glucose homeostasis traits and only minimally impact risk of T2DM in the Old Order Amish (PMID:23767996)
• Insulin Like Growth Factor I treatment and SOCS7 loss have synergistically resulted in increased growth and migration of MCF7 and in increased migration of MDA-MB-231 cells. (PMID:24046004)
• This SOCS7 knockdown-attributed effect could be due to a precise anti-PLCg-1 role. (PMID:25162020)
• This study showed that increased protein levels of SOCS-4 and SOCS-7 in Alzheimer’s disease brains. (PMID:25286386)
• Long noncoding RNA UCA1 regulates HCV replication and antiviral response via miR-145-5p/SOCS7/IFN pathway. (PMID:34345210)
• The E3 ubiquitin ligase SOCS-7 reverses immunosuppression via Shc1 signaling in hepatocellular carcinoma. (PMID:35042950)
• Lack of association between SOCS3 and SOCS7 polymorphisms and psoriasis. (PMID:36169255)
• SOCS7-Derived BC-Box Motif Peptide Mediated Cholinergic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells. (PMID:36769102)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	socs7	ENSDARG00000077018
mus_musculus	Socs7	ENSMUSG00000038485
rattus_norvegicus	Socs7	ENSRNOG00000059008
drosophila_melanogaster	Socs16D	FBGN0030869
caenorhabditis_elegans	F39B2.5	WBGENE00009556

Paralogs (7): CISH (ENSG00000114737), SOCS2 (ENSG00000120833), SOCS6 (ENSG00000170677), SOCS5 (ENSG00000171150), SOCS4 (ENSG00000180008), SOCS3 (ENSG00000184557), SOCS1 (ENSG00000185338)

Protein

Protein identifiers

Suppressor of cytokine signaling 7 — O14512 (reviewed: O14512)

Alternative names: Nck, Ash and phospholipase C gamma-binding protein, Nck-associated protein 4

All UniProt accessions (4): O14512, A0A087WZ14, A0A087X1Q5, A0A5F9YLF9

UniProt curated annotations — full annotation on UniProt →

Function. Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA.

Subunit / interactions. Substrate-recognition component of the ECS(SOCS7) complex, composed of SOCS7, CUL5, ELOB, ELOC and RNF7/RBX2. Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, PLCG1, SORBS3/vinexin, and phosphorylated STAT3 and STAT5. Interacts with SEPT6. Interacts with phosphorylated IRS4 and PIK3R1.

Subcellular location. Cytoplasm. Nucleus. Cell membrane.

Tissue specificity. Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.

Domain organisation. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

Induction. By IL6/interleukin-6, prolactin and growth hormone.

Pathway. Protein modification; protein ubiquitination.

Isoforms (2)

UniProt ID	Names	Canonical?
O14512-1	1	yes
O14512-2	2

RefSeq proteins (1): NP_055413* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000980	SH2	Domain
IPR001496	SOCS_box	Domain
IPR035866	SOCS7_SH2	Domain
IPR036036	SOCS_box-like_dom_sf	Homologous_superfamily
IPR036860	SH2_dom_sf	Homologous_superfamily
IPR037346	SOCS7_SOCS	Domain

Pfam: PF00017, PF07525

UniProt features (16 total): compositionally biased region 5, region of interest 5, domain 2, chain 1, splice variant 1, mutagenesis site 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O14512-F1	55.83	0.12

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (1):

Position	Phenotype
425–427	loss of irs1 ubiquitination and degradation.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 179 (showing top): GOBP_RESPONSE_TO_NITROGEN_COMPOUND, MIDORIKAWA_AMPLIFIED_IN_LIVER_CANCER, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_LAYER_FORMATION_IN_CEREBRAL_CORTEX, GOBP_NEUROGENESIS, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS, GOBP_FOREBRAIN_DEVELOPMENT, GOBP_FOREBRAIN_CELL_MIGRATION, MODULE_205, GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS, FOSTER_TOLERANT_MACROPHAGE_UP, GOBP_RESPONSE_TO_INSULIN, GOBP_TELENCEPHALON_GLIAL_CELL_MIGRATION, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4

GO Biological Process (8): insulin receptor signaling pathway (GO:0008286), negative regulation of signal transduction (GO:0009968), protein ubiquitination (GO:0016567), layer formation in cerebral cortex (GO:0021819), intracellular signal transduction (GO:0035556), proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161), regulation of neuron migration (GO:2001222), reelin-mediated signaling pathway (GO:0038026)

GO Molecular Function (5): SH3 domain binding (GO:0017124), signaling adaptor activity (GO:0035591), phosphorylation-dependent protein binding (GO:0140031), ubiquitin-like ligase-substrate adaptor activity (GO:1990756), protein binding (GO:0005515)

GO Cellular Component (6): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829), plasma membrane (GO:0005886), Cul5-RING ubiquitin ligase complex (GO:0031466), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
signal transduction	2
intracellular anatomical structure	2
cell surface receptor protein tyrosine kinase signaling pathway	1
cellular response to insulin stimulus	1
regulation of signal transduction	1
negative regulation of cell communication	1
negative regulation of signaling	1
negative regulation of response to stimulus	1
protein modification by small protein conjugation	1
cerebral cortex radial glia-guided migration	1
anatomical structure formation involved in morphogenesis	1
ubiquitin-dependent protein catabolic process	1
proteasomal protein catabolic process	1
neuron migration	1
regulation of cell migration	1
cell surface receptor signaling pathway	1
protein domain specific binding	1
protein-macromolecule adaptor activity	1
modification-dependent protein binding	1
enzyme-substrate adaptor activity	1
binding	1
intracellular membrane-bounded organelle	1
cytoplasm	1
membrane	1
cell periphery	1
cullin-RING ubiquitin ligase complex	1

Protein interactions and networks

STRING

708 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SOCS7	CUL5	Q93034	834
SOCS7	NCK1	P16333	802
SOCS7	SEPTIN6	Q14141	785
SOCS7	SEPTIN7	Q16181	775
SOCS7	ELOC	Q15369	757
SOCS7	IRS4	O14654	713
SOCS7	H3BTC1	H3BTC1	713
SOCS7	RNF7	Q9UBF6	669
SOCS7	ELOB	Q15370	638
SOCS7	LCK	P06239	628
SOCS7	SEPTIN11	Q9NVA2	574
SOCS7	SEPTIN8	Q92599	571
SOCS7	NCK2	O43639	565
SOCS7	IRS1	P35568	560
SOCS7	TP53	P04637	536

IntAct

64 interactions, top by confidence:

A	B	Type	Score
CUL5	SOCS2	psi-mi:“MI:0914”(association)	0.880
SOCS7	SORBS3	psi-mi:“MI:0915”(physical association)	0.690
SORBS3	SOCS7	psi-mi:“MI:0915”(physical association)	0.690
SORBS3	SOCS7	psi-mi:“MI:0403”(colocalization)	0.690
SOCS7	NCK2	psi-mi:“MI:0915”(physical association)	0.670
SOCS7	NCK2	psi-mi:“MI:0914”(association)	0.670
CUL5	SOCS7	psi-mi:“MI:0914”(association)	0.640
SOCS7	EXOSC8	psi-mi:“MI:0915”(physical association)	0.560
SOCS7	TNS2	psi-mi:“MI:0915”(physical association)	0.560
SOCS7	MDFI	psi-mi:“MI:0915”(physical association)	0.560
	SOCS7	psi-mi:“MI:0915”(physical association)	0.560
SOCS7	HSPB8	psi-mi:“MI:0915”(physical association)	0.560
SOCS7	YES1	psi-mi:“MI:0915”(physical association)	0.560
SOCS7	SORBS2	psi-mi:“MI:0915”(physical association)	0.560
SOCS7	LENG8	psi-mi:“MI:0915”(physical association)	0.560
SOCS7	GAS2L2	psi-mi:“MI:0915”(physical association)	0.560
SOCS7	NSMF	psi-mi:“MI:0915”(physical association)	0.560
SOCS7	MISP	psi-mi:“MI:0915”(physical association)	0.560
SOCS7	GRB2	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	SOCS7	psi-mi:“MI:0915”(physical association)	0.560
RNF7	SOCS7	psi-mi:“MI:0914”(association)	0.530
SOCS7	ABI1	psi-mi:“MI:0407”(direct interaction)	0.440
SOCS7	SORBS3	psi-mi:“MI:0915”(physical association)	0.370
SEPTIN6	SOCS7	psi-mi:“MI:0914”(association)	0.350
CUL5	DDX3X	psi-mi:“MI:0914”(association)	0.350
RNF7	SOCS2	psi-mi:“MI:0914”(association)	0.350

BioGRID (53): DAB1 (Reconstituted Complex), CUL5 (Affinity Capture-Western), DAB1 (Biochemical Activity), SOCS7 (Affinity Capture-MS), SOCS7 (Two-hybrid), SOCS7 (Two-hybrid), SOCS7 (Two-hybrid), SOCS7 (Two-hybrid), SOCS7 (Two-hybrid), SOCS7 (Two-hybrid), SOCS7 (Two-hybrid), SOCS7 (Two-hybrid), SOCS7 (Two-hybrid), SOCS7 (Two-hybrid), SOCS7 (Two-hybrid)

ESM2 similar proteins: A0A1W2PRP0, A6NCS4, A7Y7W2, O14512, O43638, O57601, O70220, O96004, P07812, P09023, P10085, P10284, P17483, P22091, P24899, P50548, P52954, P52955, P55318, P57100, P63156, P63157, P70447, P79772, P97832, Q02346, Q05917, Q0VCE2, Q12952, Q1XID0, Q28555, Q3I5G5, Q3Y598, Q60688, Q61660, Q63244, Q63250, Q64279, Q64305, Q64731

Diamond homologs: G5ECJ6, O00459, O08908, O14508, O14512, O14544, O35716, O35717, O46404, O88582, P00519, P00520, P00521, P10447, P14234, P15498, P23726, P23727, P26450, P27870, P27986, P42684, P54100, P62993, P62994, Q08012, Q08DN7, Q45FX5, Q4JIM5, Q54RB7, Q5R4J7, Q5R685, Q5RCM6, Q60631, Q62662, Q63787, Q63788, Q63789, Q64143, Q6P6U0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

80 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	69
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

4104 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:38366388:T:C	F388L	1.000
17:38366389:T:C	F388S	1.000
17:38366389:T:G	F388C	1.000
17:38366390:T:A	F388L	1.000
17:38366390:T:G	F388L	1.000
17:38366397:A:C	S391R	1.000
17:38366399:C:A	S391R	1.000
17:38366399:C:G	S391R	1.000
17:38366401:T:A	L392H	1.000
17:38366401:T:C	L392P	1.000
17:38366410:T:C	L395S	1.000
17:38366410:T:G	L395W	1.000
17:38367886:G:A	G399D	1.000
17:38367888:T:A	W400R	1.000
17:38367888:T:C	W400R	1.000
17:38367889:G:C	W400S	1.000
17:38367890:G:C	W400C	1.000
17:38367890:G:T	W400C	1.000
17:38367891:T:C	Y401H	1.000
17:38367891:T:G	Y401D	1.000
17:38367892:A:G	Y401C	1.000
17:38367894:T:A	W402R	1.000
17:38367894:T:C	W402R	1.000
17:38367895:G:C	W402S	1.000
17:38367896:G:C	W402C	1.000
17:38367896:G:T	W402C	1.000
17:38367897:G:A	G403R	1.000
17:38367897:G:C	G403R	1.000
17:38367897:G:T	G403W	1.000
17:38367898:G:A	G403E	1.000

dbSNP variants (sampled 300 via entrez): RS1000023004 (17:38405993 T>A), RS1000121574 (17:38363122 G>A), RS1000172442 (17:38377616 C>T), RS1000177959 (17:38394045 T>G), RS1000197754 (17:38358995 A>G,T), RS1000305162 (17:38369827 G>A), RS1000319158 (17:38376924 A>T), RS1000319239 (17:38375875 A>G), RS1000346629 (17:38357734 A>C,G), RS1000400026 (17:38383729 A>G), RS1000538427 (17:38382016 T>C), RS1000571634 (17:38390563 C>T), RS1000586876 (17:38370812 A>G), RS1000622468 (17:38353732 A>G,T), RS1000663207 (17:38388184 C>T)

Disease associations

OMIM: gene MIM:608788 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases abundance, increases expression	2
Benzo(a)pyrene	increases expression, increases methylation	2
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
methylparaben	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
resorcinol	decreases expression	1
mono(carboxy-isooctyl)phthalate	affects expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	decreases expression, increases abundance	1
Cadmium	increases abundance, decreases expression	1
Carbamazepine	affects expression	1
Chelating Agents	affects binding, increases expression	1
Copper	affects binding, increases expression	1
Diclofenac	affects expression	1
Doxorubicin	decreases expression	1
Formaldehyde	decreases expression	1
Methylcholanthrene	affects binding, increases reaction	1
Tretinoin	decreases expression	1
Urethane	increases expression	1
Valproic Acid	decreases expression	1
Cyclosporine	increases expression	1
Antirheumatic Agents	affects expression	1
Cadmium Chloride	decreases expression, increases abundance	1
Simvastatin	increases expression	1
Particulate Matter	increases abundance, increases expression	1

Cellosaurus cell lines

4 cell lines: 3 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D8B8	Ubigene A-549 SOCS7 KO	Cancer cell line	Male
CVCL_D8VZ	Ubigene HCT 116 SOCS7 KO	Cancer cell line	Male
CVCL_D9SM	Ubigene HEK293 SOCS7 KO	Transformed cell line	Female
CVCL_E0PN	Ubigene HeLa SOCS7 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.