SOS1-IT1

Summary

SOS1-IT1 (SOS1 intronic transcript 1, HGNC:41385) is a long non-coding RNA gene on chromosome 2p22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41385
Approved symbol	SOS1-IT1
Name	SOS1 intronic transcript 1
Location	2p22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229692
Ensembl biotype	lncRNA
Entrez	100505911
RNAcentral	URS0000315D76 — lncRNA, 1191 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000420644, ENST00000594472, ENST00000609942

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000420644 — 2 exons

Exon	Start	End
ENSE00001622893	38993410	38993857
ENSE00001699199	38992976	38993066

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 83.31.

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.31	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.89	gold quality
colonic epithelium	UBERON:0000397	78.25	gold quality
cortical plate	UBERON:0005343	76.53	gold quality
ventricular zone	UBERON:0003053	76.07	gold quality
adrenal tissue	UBERON:0018303	75.29	gold quality
ganglionic eminence	UBERON:0004023	74.18	gold quality
calcaneal tendon	UBERON:0003701	72.89	gold quality
right ovary	UBERON:0002118	71.79	gold quality
lower esophagus	UBERON:0013473	71.65	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.62	gold quality
bone marrow cell	CL:0002092	71.51	silver quality
left ovary	UBERON:0002119	71.23	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.88	gold quality
vermiform appendix	UBERON:0001154	70.60	gold quality
islet of Langerhans	UBERON:0000006	70.19	gold quality
lymph node	UBERON:0000029	69.19	gold quality
descending thoracic aorta	UBERON:0002345	69.15	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.08	gold quality
leukocyte	CL:0000738	68.91	gold quality
right coronary artery	UBERON:0001625	68.91	gold quality
monocyte	CL:0000576	68.81	gold quality
smooth muscle tissue	UBERON:0001135	68.81	gold quality
omental fat pad	UBERON:0010414	68.81	gold quality
mucosa of stomach	UBERON:0001199	68.79	gold quality
peritoneum	UBERON:0002358	68.73	gold quality
body of uterus	UBERON:0009853	68.72	gold quality
prefrontal cortex	UBERON:0000451	68.33	gold quality
heart left ventricle	UBERON:0002084	68.23	gold quality
left lobe of thyroid gland	UBERON:0001120	67.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.39

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.