SOX21-AS1

Summary

SOX21-AS1 (SOX21 antisense RNA 1, HGNC:39807) is a long non-coding RNA gene on chromosome 13q32.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39807
Approved symbol	SOX21-AS1
Name	SOX21 antisense RNA 1
Location	13q32.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227640
Ensembl biotype	lncRNA
Entrez	100507533
RNAcentral	URS000075C72F — lncRNA, 2986 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000438290, ENST00000665450, ENST00000690218

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000438290 — 2 exons

Exon	Start	End
ENSE00001698723	94713638	94716246
ENSE00001762666	94712716	94713393

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 80.10.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5943 / max 37.0781, expressed in 201 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
135675	0.5943	201

Top tissues by expression

211 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	80.10	gold quality
ganglionic eminence	UBERON:0004023	77.44	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.65	silver quality
esophagus mucosa	UBERON:0002469	74.67	gold quality
amygdala	UBERON:0001876	74.32	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.24	gold quality
skin of leg	UBERON:0001511	73.10	gold quality
skin of abdomen	UBERON:0001416	72.96	gold quality
caudate nucleus	UBERON:0001873	72.59	gold quality
putamen	UBERON:0001874	72.13	gold quality
lower esophagus mucosa	UBERON:0035834	71.96	gold quality
ectocervix	UBERON:0012249	71.91	gold quality
anterior cingulate cortex	UBERON:0009835	71.89	gold quality
zone of skin	UBERON:0000014	71.31	gold quality
esophagus	UBERON:0001043	71.14	gold quality
nucleus accumbens	UBERON:0001882	70.44	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.92	gold quality
right frontal lobe	UBERON:0002810	69.78	gold quality
medial globus pallidus	UBERON:0002477	69.44	gold quality
body of stomach	UBERON:0001161	68.41	gold quality
hypothalamus	UBERON:0001898	68.39	gold quality
prefrontal cortex	UBERON:0000451	67.71	gold quality
palpebral conjunctiva	UBERON:0001812	67.60	gold quality
esophagus squamous epithelium	UBERON:0006920	67.24	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.04	gold quality
stomach	UBERON:0000945	66.64	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.28	gold quality
neocortex	UBERON:0001950	65.86	gold quality
bronchial epithelial cell	CL:0002328	65.77	gold quality
Ammon’s horn	UBERON:0001954	64.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.83

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 16)

• Study identified SOX21-AS1 as susceptible dysfunction correlated with promoter hypermethylation in oral squamous cell carcinoma (OSCC). Low SOX21-AS1 expression may be an adverse prognostic biomarker for OSCC. (PMID:27933111)
• Knockdown of SOX21-AS1 suppressed cervical cancer cell proliferation, migration, and invasion, as well as epithelial to mesenchymal transition progress. Furthermore, microRNA-7 (miR-7) interacted with SOX21-AS1 by directly targeting the miRNA-binding site in the SOX21-AS1 sequence. (PMID:30912129)
• Hypomethylation of the lncRNA SOX21-AS1 is associated with cervical cancer. (PMID:31369759)
• Long non-coding RNA SOX21-AS1 promotes cell proliferation and invasion through upregulating PAK7 expression by sponging miR-144-3p in glioma cells. (PMID:31973536)
• Knockdown of long non-coding RNA SOX21-AS1 attenuates amyloid-beta-induced neuronal damage by sponging miR-107. (PMID:32124921)
• Long noncoding RNA SOX21-AS1 regulates the progression of triple-negative breast cancer through regulation of miR-520a-5p/ORMDL3 axis. (PMID:32277517)
• Silencing of long non-coding RNA SOX21-AS1 inhibits lung adenocarcinoma invasion and migration by impairing TSPAN8 via transcription factor GATA6. (PMID:32698071)
• Aberrant Methylation of the SOX21-AS1 Promoter Region Promotes Gene Expression and Its Clinical Value in Cervical Cancer. (PMID:33095426)
• Long non-coding RNA SOX21-AS1 enhances the stemness of breast cancer cells via the Hippo pathway. (PMID:33103351)
• LncRNA SOX21-AS1 Promotes the Growth and Invasiveness of Osteosarcoma Cells Through miR-7-5p/IRS2 Regulatory Network. (PMID:33341286)
• SOX21-AS1 modulates neuronal injury of MMP(+)-treated SH-SY5Y cells via targeting miR-7-5p and inhibiting IRS2. (PMID:33421490)
• SRY-Box 21 Antisense RNA 1 Knockdown Diminishes Amyloid Beta25-35-Induced Neuronal Damage by miR-132/PI3K/AKT Pathway. (PMID:34146195)
• Long non-coding RNA SOX21-AS1 modulates lung cancer progress upon microRNA miR-24-3p/PIM2 axis. (PMID:34511042)
• Downregulation of SOX21-AS1 Alleviated Cisplatin Resistance in Cervical Cancer Through Epithelial-Mesenchymal Transition Inhibition. (PMID:36039935)
• SOX21-AS1 activated by STAT6 promotes pancreatic cancer progression via up-regulation of SOX21. (PMID:36335356)
• Long non-coding RNA SOX21-AS1: A potential tumor oncogene in human cancers. (PMID:37633003)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.