SPACA6-AS1

Summary

SPACA6-AS1 (SPACA6 antisense RNA 1, HGNC:49383) is a long non-coding RNA gene on chromosome 19q13.41.

Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex.

Source: NCBI Gene 102238594 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49383
Approved symbol	SPACA6-AS1
Name	SPACA6 antisense RNA 1
Location	19q13.41
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000269959
Ensembl biotype	lncRNA
Entrez	102238594
RNAcentral	URS0000050347 — lncRNA, 3962 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000602324

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000602324 — 2 exons

Exon	Start	End
ENSE00003253062	51685363	51688501
ENSE00003325668	51692634	51693456

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 72.93.

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	72.93	silver quality
colonic epithelium	UBERON:0000397	69.53	silver quality
ventricular zone	UBERON:0003053	58.61	silver quality
cortical plate	UBERON:0005343	58.33	silver quality
ganglionic eminence	UBERON:0004023	58.24	gold quality
tonsil	UBERON:0002372	57.81	silver quality
urinary bladder	UBERON:0001255	57.10	silver quality
hindlimb stylopod muscle	UBERON:0004252	55.78	gold quality
cerebellum	UBERON:0002037	55.55	gold quality
cerebellar cortex	UBERON:0002129	55.45	gold quality
cerebellar hemisphere	UBERON:0002245	55.44	gold quality
right hemisphere of cerebellum	UBERON:0014890	55.41	gold quality
stromal cell of endometrium	CL:0002255	55.10	silver quality
placenta	UBERON:0001987	54.62	gold quality
omental fat pad	UBERON:0010414	54.27	gold quality
ovary	UBERON:0000992	53.10	gold quality
left ovary	UBERON:0002119	52.75	gold quality
right ovary	UBERON:0002118	52.51	gold quality
right testis	UBERON:0004534	52.51	gold quality
testis	UBERON:0000473	52.46	gold quality
left testis	UBERON:0004533	52.34	gold quality
uterine cervix	UBERON:0000002	52.28	gold quality
liver	UBERON:0002107	52.27	silver quality
adipose tissue	UBERON:0001013	52.24	gold quality
substantia nigra	UBERON:0002038	51.04	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	50.91	gold quality
body of uterus	UBERON:0009853	50.86	gold quality
myometrium	UBERON:0001296	50.72	gold quality
pituitary gland	UBERON:0000007	50.62	gold quality
prefrontal cortex	UBERON:0000451	50.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.57

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• A Novel ceRNA Regulatory Network Involving the Long Non-Coding Antisense RNA SPACA6P-AS, miR-125a and its mRNA Targets in Hepatocarcinoma Cells. (PMID:32709089)
• SPACA6P-AS: a trailblazer in breast cancer pathobiology and therapeutics. (PMID:38922500)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.