SPAG5-AS1

Summary

SPAG5-AS1 (SPAG5 antisense RNA 1, HGNC:41140) is a long non-coding RNA gene on chromosome 17q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41140
Approved symbol	SPAG5-AS1
Name	SPAG5 antisense RNA 1
Location	17q11.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227543
Ensembl biotype	lncRNA
Entrez	100506436
RNAcentral	URS000075B48C — lncRNA, 1379 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 10 lncRNA, 1 retained_intron

ENST00000414744, ENST00000424210, ENST00000554154, ENST00000556050, ENST00000584675, ENST00000670419, ENST00000782659, ENST00000782660, ENST00000782661, ENST00000782662, ENST00000782663

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414744 — 2 exons

Exon	Start	End
ENSE00001177063	28598790	28599839
ENSE00003750390	28616285	28617377

Expression profiles

Bgee: expression breadth ubiquitous, 166 present calls, max score 91.85.

FANTOM5 (CAGE): breadth broad, TPM avg 3.4341 / max 156.9402, expressed in 547 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
160045	2.9698	462
160044	0.4023	158
160046	0.0619	27

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cardiac muscle of right atrium	UBERON:0003379	91.85	gold quality
kidney epithelium	UBERON:0004819	91.26	gold quality
right testis	UBERON:0004534	90.96	gold quality
left testis	UBERON:0004533	90.88	gold quality
left ventricle myocardium	UBERON:0006566	90.74	gold quality
pancreatic ductal cell	CL:0002079	90.44	silver quality
testis	UBERON:0000473	88.05	gold quality
myocardium	UBERON:0002349	83.56	gold quality
epithelial cell of pancreas	CL:0000083	80.74	gold quality
tibialis anterior	UBERON:0001385	80.54	silver quality
ileal mucosa	UBERON:0000331	80.45	silver quality
sperm	CL:0000019	78.93	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.85	gold quality
right lobe of liver	UBERON:0001114	78.36	gold quality
quadriceps femoris	UBERON:0001377	78.12	gold quality
vastus lateralis	UBERON:0001379	77.68	gold quality
adult mammalian kidney	UBERON:0000082	77.60	gold quality
granulocyte	CL:0000094	77.47	gold quality
upper arm skin	UBERON:0004263	76.66	gold quality
bone marrow cell	CL:0002092	76.56	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	76.25	gold quality
nasal cavity epithelium	UBERON:0005384	75.65	gold quality
deltoid	UBERON:0001476	75.31	gold quality
monocyte	CL:0000576	74.81	gold quality
leukocyte	CL:0000738	74.66	gold quality
small intestine Peyer’s patch	UBERON:0003454	74.55	gold quality
right lobe of thyroid gland	UBERON:0001119	74.31	gold quality
metanephros cortex	UBERON:0010533	74.31	gold quality
spleen	UBERON:0002106	74.13	gold quality
kidney	UBERON:0002113	73.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long Non-coding RNA SPAG5-AS1 Attenuates Diabetic Retinal Vascular Dysfunction by Inhibiting Human Retinal Microvascular Endothelial Cell Proliferation, Migration, and Tube Formation by Regulating the MicroRNA-1224-5p/IRS-1 Axis. (PMID:36346578)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.