SPATA8

Summary

SPATA8 (spermatogenesis associated 8, HGNC:28676) is a long non-coding RNA gene on chromosome 15q26.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28676
Approved symbol	SPATA8
Name	spermatogenesis associated 8
Location	15q26.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC44294, SRG8
Ensembl gene	ENSG00000185594
Ensembl biotype	lncRNA
OMIM	613948
Entrez	145946
RNAcentral	URS0000D7809D — lncRNA, 897 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 10 lncRNA, 1 retained_intron

ENST00000558553, ENST00000560327, ENST00000561002, ENST00000649986, ENST00000671619, ENST00000723770, ENST00000723771, ENST00000723772, ENST00000723773, ENST00000723774, ENST00000723775

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558553 — 3 exons

Exon	Start	End
ENSE00002551292	96783411	96783589
ENSE00003838396	96784153	96784259
ENSE00004045760	96784996	96785615

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 99.41.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.1395 / max 1222.4403, expressed in 4 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
148765	1.0057	4
148764	0.1021	3
207664	0.0147	3
148766	0.0106	3
207663	0.0063	3

Top tissues by expression

219 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	99.41	gold quality
right testis	UBERON:0004534	99.05	gold quality
adult organism	UBERON:0007023	97.57	gold quality
sperm	CL:0000019	97.06	gold quality
testis	UBERON:0000473	96.40	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.68	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.59	gold quality
pancreatic ductal cell	CL:0002079	80.13	silver quality
kidney epithelium	UBERON:0004819	75.11	gold quality
deltoid	UBERON:0001476	72.95	gold quality
nasal cavity epithelium	UBERON:0005384	69.30	gold quality
ileal mucosa	UBERON:0000331	69.29	silver quality
parotid gland	UBERON:0001831	69.15	gold quality
colonic epithelium	UBERON:0000397	68.51	silver quality
buccal mucosa cell	CL:0002336	68.38	silver quality
myocardium	UBERON:0002349	68.05	gold quality
left ventricle myocardium	UBERON:0006566	66.24	gold quality
skeletal muscle tissue	UBERON:0001134	65.38	gold quality
cardiac muscle of right atrium	UBERON:0003379	65.38	gold quality
epithelium of mammary gland	UBERON:0003244	64.20	gold quality
mammary duct	UBERON:0001765	64.08	gold quality
superficial temporal artery	UBERON:0001614	63.70	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	62.62	gold quality
quadriceps femoris	UBERON:0001377	62.48	gold quality
biceps brachii	UBERON:0001507	62.23	gold quality
heart right ventricle	UBERON:0002080	62.16	gold quality
vastus lateralis	UBERON:0001379	60.44	gold quality
nasal cavity mucosa	UBERON:0001826	60.27	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.03	gold quality
prefrontal cortex	UBERON:0000451	58.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population. (PMID:27569236)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.