SPDYE10

Summary

SPDYE10 (speedy/RINGO cell cycle regulator family member E10, HGNC:51506) is a protein-coding gene on chromosome 7q11.23, encoding Speedy protein E10 (P0DUX0).

Enables acetylcholine receptor regulator activity.

Source: NCBI Gene 643862 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001382505

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51506
Approved symbol	SPDYE10
Name	speedy/RINGO cell cycle regulator family member E10
Location	7q11.23
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000274570
Ensembl biotype	protein_coding
Entrez	643862

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 2 protein_coding_CDS_not_defined, 2 protein_coding

ENST00000576332, ENST00000612005, ENST00000682856, ENST00000691996

RefSeq mRNA: 2 — MANE Select: NM_001382505 NM_001382504, NM_001382505

CCDS: CCDS94117

Canonical transcript exons

ENST00000691996 — 9 exons

Exon	Start	End
ENSE00002466988	73106340	73106444
ENSE00003756816	73106567	73106810
ENSE00003920331	73112123	73112705
ENSE00003924731	73110922	73111140
ENSE00003926086	73108517	73108602
ENSE00003928243	73109830	73109888
ENSE00003928607	73115357	73115542
ENSE00003930198	73155323	73155431
ENSE00003930867	73104008	73105486

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 85.86.

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	85.86	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.13	gold quality
left testis	UBERON:0004533	78.66	gold quality
testis	UBERON:0000473	78.16	gold quality
right testis	UBERON:0004534	77.48	gold quality
colonic epithelium	UBERON:0000397	76.33	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	67.63	gold quality
lower esophagus mucosa	UBERON:0035834	65.87	gold quality
adrenal tissue	UBERON:0018303	64.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.54	gold quality
liver	UBERON:0002107	61.58	gold quality
tonsil	UBERON:0002372	61.54	gold quality
right lobe of liver	UBERON:0001114	61.41	gold quality
corpus callosum	UBERON:0002336	59.77	gold quality
cerebellum	UBERON:0002037	59.62	gold quality
cerebellar cortex	UBERON:0002129	59.44	gold quality
primary visual cortex	UBERON:0002436	59.37	gold quality
cerebellar hemisphere	UBERON:0002245	59.32	gold quality
blood	UBERON:0000178	59.17	gold quality
esophagus mucosa	UBERON:0002469	58.94	gold quality
mucosa of transverse colon	UBERON:0004991	58.80	gold quality
endometrium	UBERON:0001295	58.66	gold quality
placenta	UBERON:0001987	58.56	gold quality
calcaneal tendon	UBERON:0003701	58.42	gold quality
metanephros cortex	UBERON:0010533	58.28	gold quality
adenohypophysis	UBERON:0002196	58.10	gold quality
right hemisphere of cerebellum	UBERON:0014890	57.94	gold quality
left ovary	UBERON:0002119	57.93	gold quality
spleen	UBERON:0002106	57.83	gold quality
apex of heart	UBERON:0002098	57.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.42

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Spdye4b	ENSMUSG00000029586
mus_musculus	Spdye4a	ENSMUSG00000039296
rattus_norvegicus	Spdye4	ENSRNOG00000058563

Paralogs (18): SPDYE1 (ENSG00000136206), SPDYE5 (ENSG00000170092), SPDYE2B (ENSG00000173678), SPDYE4 (ENSG00000183318), SPDYE12 (ENSG00000184616), SPDYE16 (ENSG00000185040), SPDYE17 (ENSG00000186645), SPDYE2 (ENSG00000205238), SPDYE18 (ENSG00000205482), SPDYE3 (ENSG00000214300), SPDYE21 (ENSG00000230358), SPDYE6 (ENSG00000260097), SPDYE9 (ENSG00000262461), SPDYE8 (ENSG00000273520), SPDYE11 (ENSG00000275976), SPDYE15 (ENSG00000286014), SPDYE13 (ENSG00000286038), SPDYE14 (ENSG00000286137)

Protein

Protein identifiers

Speedy protein E10 — P0DUX0 (reviewed: P0DUX0)

All UniProt accessions (1): P0DUX0

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the Speedy/Ringo family.

RefSeq proteins (2): NP_001369433, NP_001369434* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR020984	Speedy	Family
IPR057742	Speedy_E	Family

Pfam: PF11357

UniProt features (3 total): chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DUX0-F1	71.23	0.43

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 3 (showing top): chr7q11, GOMF_KINASE_BINDING, JINESH_BLEBBISHIELD_VS_LIVE_CONTROL_UP

GO Biological Process (1): positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)

GO Molecular Function (1): protein kinase binding (GO:0019901)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of cyclin-dependent protein serine/threonine kinase activity	1
cyclin-dependent protein serine/threonine kinase activity	1
positive regulation of cell cycle	1
positive regulation of protein serine/threonine kinase activity	1
positive regulation of cyclin-dependent protein kinase activity	1
kinase binding	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0J9YY54, A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NNV3, B4DH59, F6SZT2, P0C6Y7, P0CI01, P0DKJ7, P0DKJ8, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, P79386, Q08AG5, Q13342, Q16666, Q3BBV2, Q495Y8, Q587J8, Q5JRC9, Q5QGU6, Q5RD14, Q5RKG3, Q63HK3, Q6ITT4, Q7TQI8, Q86T75, Q8IWY8, Q8N660, Q8NFV5

Diamond homologs: A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NKU9, A6NLX3, A6NNV3, P0CI01, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, Q495Y7, Q495Y8, Q5IBH6, Q5IBH7, Q5MJ68, Q5MJ70, Q8NFV5, Q8R496, Q9PU13, Q9YGL1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1018987 (7:73122961 A>G), RS10248431 (7:73146520 C>T), RS111517749 (7:73113747 T>A,C), RS111714962 (7:73150971 C>A), RS112105869 (7:73119402 A>G), RS112154436 (7:73150970 C>A), RS112388653 (7:73115273 T>C), RS112438073 (7:73156142 T>A,C), RS112511866 (7:73117244 A>G), RS1156246504 (7:73128995 A>G,T), RS1156248678 (7:73142213 G>A), RS1156285684 (7:73114606 G>A), RS1156291901 (7:73156041 T>C), RS1156374586 (7:73114150 C>A,T), RS1156393958 (7:73156636 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Okadaic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.