SPDYE11

Summary

SPDYE11 (speedy/RINGO cell cycle regulator family member E11, HGNC:51507) is a protein-coding gene on chromosome 7q11.23, encoding Speedy protein E11 (P0DTA3). Acts as a modulator of the nicotinic acetylcholine receptor alpha-7 (CHRNA7) activity.

Enables acetylcholine receptor regulator activity.

Source: NCBI Gene 100996746 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001351349

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51507
Approved symbol	SPDYE11
Name	speedy/RINGO cell cycle regulator family member E11
Location	7q11.23
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000275976
Ensembl biotype	protein_coding
Entrez	100996746

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 retained_intron

ENST00000340073, ENST00000573748

RefSeq mRNA: 2 — MANE Select: NM_001351349 NM_001351349, NM_001422015

CCDS: CCDS94115

Canonical transcript exons

ENST00000340073 — 8 exons

Exon	Start	End
ENSE00002441325	73057790	73057911
ENSE00002444054	73047862	73049343
ENSE00002475456	73055982	73056564
ENSE00002495080	73054774	73054992
ENSE00002519509	73053682	73053740
ENSE00003844875	73050197	73050301
ENSE00003847040	73050424	73050667
ENSE00003847951	73052369	73052454

Expression profiles

Bgee: expression breadth ubiquitous, 127 present calls, max score 77.02.

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
urinary bladder	UBERON:0001255	77.02	gold quality
bone marrow cell	CL:0002092	65.98	silver quality
colonic epithelium	UBERON:0000397	64.65	silver quality
skeletal muscle tissue	UBERON:0001134	64.60	gold quality
bone marrow	UBERON:0002371	63.10	silver quality
monocyte	CL:0000576	62.43	gold quality
stromal cell of endometrium	CL:0002255	61.93	gold quality
leukocyte	CL:0000738	61.82	gold quality
ganglionic eminence	UBERON:0004023	59.85	gold quality
ventricular zone	UBERON:0003053	59.73	gold quality
right testis	UBERON:0004534	57.54	gold quality
cortical plate	UBERON:0005343	57.39	silver quality
testis	UBERON:0000473	56.45	gold quality
left testis	UBERON:0004533	56.16	gold quality
liver	UBERON:0002107	56.15	gold quality
blood	UBERON:0000178	55.64	gold quality
calcaneal tendon	UBERON:0003701	55.37	gold quality
granulocyte	CL:0000094	55.29	gold quality
hindlimb stylopod muscle	UBERON:0004252	54.34	silver quality
adrenal tissue	UBERON:0018303	54.25	gold quality
prefrontal cortex	UBERON:0000451	53.78	gold quality
muscle of leg	UBERON:0001383	53.59	gold quality
superior frontal gyrus	UBERON:0002661	53.56	gold quality
lymph node	UBERON:0000029	53.26	gold quality
gastrocnemius	UBERON:0001388	52.89	gold quality
kidney	UBERON:0002113	52.82	gold quality
tonsil	UBERON:0002372	52.69	gold quality
cortex of kidney	UBERON:0001225	52.50	gold quality
placenta	UBERON:0001987	52.08	gold quality
frontal cortex	UBERON:0001870	51.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Spdye4b	ENSMUSG00000029586
mus_musculus	Spdye4a	ENSMUSG00000039296
rattus_norvegicus	Spdye4	ENSRNOG00000058563

Paralogs (18): SPDYE1 (ENSG00000136206), SPDYE5 (ENSG00000170092), SPDYE2B (ENSG00000173678), SPDYE4 (ENSG00000183318), SPDYE12 (ENSG00000184616), SPDYE16 (ENSG00000185040), SPDYE17 (ENSG00000186645), SPDYE2 (ENSG00000205238), SPDYE18 (ENSG00000205482), SPDYE3 (ENSG00000214300), SPDYE21 (ENSG00000230358), SPDYE6 (ENSG00000260097), SPDYE9 (ENSG00000262461), SPDYE8 (ENSG00000273520), SPDYE10 (ENSG00000274570), SPDYE15 (ENSG00000286014), SPDYE13 (ENSG00000286038), SPDYE14 (ENSG00000286137)

Protein

Protein identifiers

Speedy protein E11 — P0DTA3 (reviewed: P0DTA3)

All UniProt accessions (1): P0DTA3

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a modulator of the nicotinic acetylcholine receptor alpha-7 (CHRNA7) activity.

Similarity. Belongs to the Speedy/Ringo family.

RefSeq proteins (2): NP_001338278, NP_001408944 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR020984	Speedy	Family
IPR057742	Speedy_E	Family

Pfam: PF11357

UniProt features (3 total): chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DTA3-F1	70.55	0.42

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 4 (showing top): chr7q11, GOMF_KINASE_BINDING, GOMF_SIGNALING_RECEPTOR_REGULATOR_ACTIVITY, GOMF_NEUROTRANSMITTER_RECEPTOR_REGULATOR_ACTIVITY

GO Biological Process (1): positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)

GO Molecular Function (2): protein kinase binding (GO:0019901), acetylcholine receptor regulator activity (GO:0030548)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of cyclin-dependent protein serine/threonine kinase activity	1
cyclin-dependent protein serine/threonine kinase activity	1
positive regulation of cell cycle	1
positive regulation of protein serine/threonine kinase activity	1
positive regulation of cyclin-dependent protein kinase activity	1
kinase binding	1
acetylcholine receptor activity	1
neurotransmitter receptor regulator activity	1

Protein interactions and networks

STRING

2134 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SPDYE11	ZDHHC11B	P0C7U3	576
SPDYE11	ZFP30	Q9Y2G7	507
SPDYE11	ZNF512	Q96ME7	479
SPDYE11	TBL3	Q12788	438
SPDYE11	DDX49	Q9Y6V7	415
SPDYE11	MICALL1	Q8N3F8	400
SPDYE11	SACK1B	Q5T0W9	400
SPDYE11	DNAH8	Q96JB1	370
SPDYE11	EIF3L	Q9Y262	366
SPDYE11	RPS5	P46782	334
SPDYE11	EPRS1	P07814	304
SPDYE11	YARS1	P54577	277
SPDYE11	ZBTB34	Q8NCN2	272
SPDYE11	FKBP8	Q14318	271
SPDYE11	ZC3H12A	Q5D1E8	225

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0J9YY54, A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NNV3, B4DH59, F6SZT2, P0C6Y7, P0CI01, P0DKJ7, P0DKJ8, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, P79386, Q08AG5, Q13342, Q16666, Q3BBV2, Q495Y8, Q587J8, Q5JRC9, Q5QGU6, Q5RD14, Q5RKG3, Q63HK3, Q6ITT4, Q7TQI8, Q86T75, Q8IWY8, Q8N660, Q8NFV5

Diamond homologs: A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NKU9, A6NLX3, A6NNV3, P0CI01, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, Q495Y7, Q495Y8, Q5IBH6, Q5IBH7, Q5MJ68, Q5MJ70, Q8NFV5, Q8R496, Q9PU13, Q9YGL1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1742 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1156452073 (7:73055330 G>C), RS1159915971 (7:73055607 CT>C,CTT), RS1163745417 (7:73055619 CTTTTTTTTTTTTT>C,CT,CTT,CTTTT,CTTTTT,CTTTTTT,CTTTTTTT,CTTTTTTTT,CTTTTTTTTT,CTTTTTTTTTT,CTTTTTTTTTTT,CTTTTTTTTTTTT,CTTTTTTTTTTTTTT,CTTTTTTTTTTTTTTT,CTTTTTTTTTTTTTTTT,CTTTTTTTTTTTTTTTTTTTTTTTT), RS1170369935 (7:73055688 G>A), RS1174870716 (7:73055985 A>C), RS1175595565 (7:73055263 C>A,G,T), RS1177920690 (7:73056045 G>T), RS1178509833 (7:73056019 G>A), RS1179166425 (7:73050149 G>A), RS1183440432 (7:73055347 G>T), RS1186395929 (7:73055622 T>C), RS1197794310 (7:73055707 C>G), RS1198090804 (7:73052215 C>T), RS1198511605 (7:73049697 G>A), RS1201647232 (7:73056070 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.