SPDYE14

Summary

SPDYE14 (speedy/RINGO cell cycle regulator family member E14, HGNC:51510) is a protein-coding gene on chromosome 7q11.23, encoding Speedy protein E14 (P0DUD3).

Predicted to enable protein kinase binding activity.

Source: NCBI Gene 641776 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001394940

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51510
Approved symbol	SPDYE14
Name	speedy/RINGO cell cycle regulator family member E14
Location	7q11.23
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000286137
Ensembl biotype	protein_coding
Entrez	641776

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000651045

RefSeq mRNA: 4 — MANE Select: NM_001394940 NM_001382494, NM_001382495, NM_001394940, NM_001422015

CCDS: CCDS94126

Canonical transcript exons

ENST00000651045 — 8 exons

Exon	Start	End
ENSE00001334566	75315948	75317429
ENSE00003845468	75312833	75312918
ENSE00003846163	75308718	75309300
ENSE00003846874	75311547	75311605
ENSE00003848387	75314624	75314867
ENSE00003850701	75314990	75315094
ENSE00003850708	75310296	75310514
ENSE00003997026	75307376	75307497

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.94.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	37.94	gold quality
ganglionic eminence	UBERON:0004023	37.30	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
muscle tissue	UBERON:0002385	34.41	gold quality
bone marrow	UBERON:0002371	32.84	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
placenta	UBERON:0001987	29.78	silver quality
liver	UBERON:0002107	29.64	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	27.60	gold quality
lymph node	UBERON:0000029	27.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
blood	UBERON:0000178	27.03	gold quality
islet of Langerhans	UBERON:0000006	26.90	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
muscle of leg	UBERON:0001383	25.25	gold quality
leukocyte	CL:0000738	24.80	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
monocyte	CL:0000576	24.52	gold quality
pancreas	UBERON:0001264	24.11	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
gastrocnemius	UBERON:0001388	23.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Spdye4b	ENSMUSG00000029586
mus_musculus	Spdye4a	ENSMUSG00000039296
rattus_norvegicus	Spdye4	ENSRNOG00000058563

Paralogs (18): SPDYE1 (ENSG00000136206), SPDYE5 (ENSG00000170092), SPDYE2B (ENSG00000173678), SPDYE4 (ENSG00000183318), SPDYE12 (ENSG00000184616), SPDYE16 (ENSG00000185040), SPDYE17 (ENSG00000186645), SPDYE2 (ENSG00000205238), SPDYE18 (ENSG00000205482), SPDYE3 (ENSG00000214300), SPDYE21 (ENSG00000230358), SPDYE6 (ENSG00000260097), SPDYE9 (ENSG00000262461), SPDYE8 (ENSG00000273520), SPDYE10 (ENSG00000274570), SPDYE11 (ENSG00000275976), SPDYE15 (ENSG00000286014), SPDYE13 (ENSG00000286038)

Protein

Protein identifiers

Speedy protein E14 — P0DUD3 (reviewed: P0DUD3)

All UniProt accessions (1): P0DUD3

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the Speedy/Ringo family.

RefSeq proteins (4): NP_001369423, NP_001369424, NP_001381869, NP_001408944 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR020984	Speedy	Family
IPR057742	Speedy_E	Family

Pfam: PF11357

UniProt features (3 total): chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DUD3-F1	70.83	0.41

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 2 (showing top): chr7q11, GOMF_KINASE_BINDING

GO Biological Process (1): positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)

GO Molecular Function (1): protein kinase binding (GO:0019901)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of cyclin-dependent protein serine/threonine kinase activity	1
cyclin-dependent protein serine/threonine kinase activity	1
positive regulation of cell cycle	1
positive regulation of protein serine/threonine kinase activity	1
positive regulation of cyclin-dependent protein kinase activity	1
kinase binding	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0J9YY54, A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NNV3, B4DH59, F6SZT2, P0C6Y7, P0CI01, P0DKJ7, P0DKJ8, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, P79386, Q08AG5, Q13342, Q16666, Q3BBV2, Q495Y8, Q587J8, Q5JRC9, Q5QGU6, Q5RD14, Q5RKG3, Q63HK3, Q6ITT4, Q7TQI8, Q86T75, Q8IWY8, Q8N660, Q8NFV5

Diamond homologs: A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NKU9, A6NLX3, A6NNV3, P0CI01, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, Q495Y7, Q495Y8, Q5IBH6, Q5IBH7, Q5MJ68, Q5MJ70, Q8NFV5, Q8R496, Q9PU13, Q9YGL1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1743 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS10233540 (7:75300777 C>G), RS10281296 (7:75301016 G>A), RS10355 (7:75288109 T>G), RS111469898 (7:75272661 C>T), RS1156337668 (7:75267991 C>T), RS1156346088 (7:75240379 C>T), RS1156417275 (7:75241759 A>C), RS1156579226 (7:75244783 AAAACAAAC>A,AAAAC), RS1156580420 (7:75271135 T>G), RS1156634869 (7:75275071 C>A,T), RS1156702536 (7:75273523 C>G,T), RS1156776437 (7:75247507 G>A,C), RS1156777531 (7:75245819 G>A), RS1156832954 (7:75275781 G>C), RS1156993752 (7:75262235 AAAAC>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Lactic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.