SPDYE15

Summary

SPDYE15 (speedy/RINGO cell cycle regulator family member E15, HGNC:51511) is a protein-coding gene on chromosome 7q11.23, encoding Speedy protein E15 (P0DUD4).

Predicted to enable protein kinase binding activity.

Source: NCBI Gene 105180391 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001382547

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51511
Approved symbol	SPDYE15
Name	speedy/RINGO cell cycle regulator family member E15
Location	7q11.23
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000286014
Ensembl biotype	protein_coding
Entrez	105180391

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000612377

RefSeq mRNA: 2 — MANE Select: NM_001382547 NM_001382547, NM_001422015

CCDS: CCDS94127

Canonical transcript exons

ENST00000612377 — 8 exons

Exon	Start	End
ENSE00001616970	75339514	75339572
ENSE00003746354	75342957	75343061
ENSE00003841928	75342591	75342834
ENSE00003842961	75340800	75340885
ENSE00003845292	75338263	75338481
ENSE00003848851	75336685	75337267
ENSE00003928886	75335343	75335464
ENSE00003929574	75343915	75345396

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.94.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	37.94	gold quality
ganglionic eminence	UBERON:0004023	37.30	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
muscle tissue	UBERON:0002385	34.41	gold quality
bone marrow	UBERON:0002371	32.84	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
placenta	UBERON:0001987	29.78	silver quality
liver	UBERON:0002107	29.64	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	27.60	gold quality
lymph node	UBERON:0000029	27.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
blood	UBERON:0000178	27.03	gold quality
islet of Langerhans	UBERON:0000006	26.90	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
muscle of leg	UBERON:0001383	25.25	gold quality
leukocyte	CL:0000738	24.80	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
monocyte	CL:0000576	24.52	gold quality
pancreas	UBERON:0001264	24.11	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
gastrocnemius	UBERON:0001388	23.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.14

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Spdye4b	ENSMUSG00000029586
mus_musculus	Spdye4a	ENSMUSG00000039296
rattus_norvegicus	Spdye4	ENSRNOG00000058563

Paralogs (18): SPDYE1 (ENSG00000136206), SPDYE5 (ENSG00000170092), SPDYE2B (ENSG00000173678), SPDYE4 (ENSG00000183318), SPDYE12 (ENSG00000184616), SPDYE16 (ENSG00000185040), SPDYE17 (ENSG00000186645), SPDYE2 (ENSG00000205238), SPDYE18 (ENSG00000205482), SPDYE3 (ENSG00000214300), SPDYE21 (ENSG00000230358), SPDYE6 (ENSG00000260097), SPDYE9 (ENSG00000262461), SPDYE8 (ENSG00000273520), SPDYE10 (ENSG00000274570), SPDYE11 (ENSG00000275976), SPDYE13 (ENSG00000286038), SPDYE14 (ENSG00000286137)

Protein

Protein identifiers

Speedy protein E15 — P0DUD4 (reviewed: P0DUD4)

All UniProt accessions (1): P0DUD4

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the Speedy/Ringo family.

RefSeq proteins (2): NP_001369476, NP_001408944 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR020984	Speedy	Family
IPR057742	Speedy_E	Family

Pfam: PF11357

UniProt features (3 total): chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DUD4-F1	70.65	0.41

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 2 (showing top): chr7q11, GOMF_KINASE_BINDING

GO Biological Process (1): positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)

GO Molecular Function (1): protein kinase binding (GO:0019901)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of cyclin-dependent protein serine/threonine kinase activity	1
cyclin-dependent protein serine/threonine kinase activity	1
positive regulation of cell cycle	1
positive regulation of protein serine/threonine kinase activity	1
positive regulation of cyclin-dependent protein kinase activity	1
kinase binding	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0J9YY54, A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NNV3, B4DH59, F6SZT2, P0C6Y7, P0CI01, P0DKJ7, P0DKJ8, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, P79386, Q08AG5, Q13342, Q16666, Q3BBV2, Q495Y8, Q587J8, Q5JRC9, Q5QGU6, Q5RD14, Q5RKG3, Q63HK3, Q6ITT4, Q7TQI8, Q86T75, Q8IWY8, Q8N660, Q8NFV5

Diamond homologs: A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NKU9, A6NLX3, A6NNV3, P0CI01, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, Q495Y7, Q495Y8, Q5IBH6, Q5IBH7, Q5MJ68, Q5MJ70, Q8NFV5, Q8R496, Q9PU13, Q9YGL1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1743 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:75338466:T:C	F112L	0.970
7:75338468:C:A	F112L	0.970
7:75338468:C:G	F112L	0.970
7:75340827:T:C	F146L	0.959
7:75340829:C:A	F146L	0.959
7:75340829:C:G	F146L	0.959
7:75342633:A:C	K179N	0.929
7:75342633:A:T	K179N	0.929
7:75339547:A:C	D128A	0.926
7:75342989:G:C	W257C	0.920
7:75342989:G:T	W257C	0.920
7:75339547:A:T	D128V	0.917
7:75340872:T:C	F161L	0.911
7:75340874:C:A	F161L	0.911
7:75340874:C:G	F161L	0.911
7:75340875:T:C	F162L	0.910
7:75340877:C:A	F162L	0.910
7:75340877:C:G	F162L	0.910
7:75340814:G:A	M141I	0.901
7:75340814:G:C	M141I	0.901
7:75340814:G:T	M141I	0.901
7:75342987:T:A	W257R	0.897
7:75342987:T:C	W257R	0.897
7:75339548:C:A	D128E	0.891
7:75339548:C:G	D128E	0.891
7:75339546:G:C	D128H	0.888
7:75339568:A:T	D135V	0.883
7:75340828:T:C	F146S	0.881
7:75342649:T:C	F185L	0.881
7:75342651:C:A	F185L	0.881

dbSNP variants (sampled 300 via entrez): RS112813791 (7:75346728 A>C), RS112905360 (7:75343257 G>A), RS113545852 (7:75339157 A>C), RS1157616239 (7:75334565 G>A), RS1164664818 (7:75334406 T>A,C), RS1194941063 (7:75334700 T>C), RS1205536951 (7:75334724 G>A), RS1236502013 (7:75334795 T>C), RS1258717922 (7:75334751 G>C,T), RS1287478221 (7:75334889 C>T), RS1304333319 (7:75334767 C>T), RS1325414630 (7:75334821 C>G), RS1326627745 (7:75334121 A>G), RS1348501494 (7:75334760 T>A,G), RS1366079322 (7:75334555 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.