SPDYE17

Summary

SPDYE17 (speedy/RINGO cell cycle regulator family member E17, HGNC:51513) is a protein-coding gene on chromosome 7q11.23, encoding Speedy protein E17 (P0DUD2).

Enables acetylcholine receptor regulator activity.

Source: NCBI Gene 102723849 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001351351

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51513
Approved symbol	SPDYE17
Name	speedy/RINGO cell cycle regulator family member E17
Location	7q11.23
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000186645
Ensembl biotype	protein_coding
Entrez	102723849

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000671986

RefSeq mRNA: 1 — MANE Select: NM_001351351 NM_001351351

CCDS: CCDS94130

Canonical transcript exons

ENST00000671986 — 8 exons

Exon	Start	End
ENSE00003890655	77024868	77025111
ENSE00003890701	77024641	77024745
ENSE00003891466	77022306	77023787
ENSE00003891570	77029233	77029451
ENSE00003893143	77028142	77028200
ENSE00003893474	77026829	77026914
ENSE00003894944	77032240	77032361
ENSE00003895720	77030441	77031023

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 76.93.

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.93	gold quality
left testis	UBERON:0004533	63.37	gold quality
testis	UBERON:0000473	63.22	gold quality
right testis	UBERON:0004534	62.73	gold quality
calcaneal tendon	UBERON:0003701	60.99	gold quality
colonic epithelium	UBERON:0000397	59.53	silver quality
tonsil	UBERON:0002372	58.34	silver quality
adrenal tissue	UBERON:0018303	58.26	gold quality
lower esophagus mucosa	UBERON:0035834	58.25	gold quality
bone marrow cell	CL:0002092	57.91	silver quality
sural nerve	UBERON:0015488	57.27	silver quality
endometrium	UBERON:0001295	56.75	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	56.55	silver quality
placenta	UBERON:0001987	55.35	gold quality
corpus callosum	UBERON:0002336	52.85	gold quality
bone marrow	UBERON:0002371	51.03	silver quality
granulocyte	CL:0000094	50.63	silver quality
cerebellar cortex	UBERON:0002129	50.27	silver quality
cerebellar hemisphere	UBERON:0002245	50.14	silver quality
liver	UBERON:0002107	50.10	silver quality
cerebellum	UBERON:0002037	49.82	silver quality
skeletal muscle tissue	UBERON:0001134	49.80	gold quality
right lobe of liver	UBERON:0001114	49.72	silver quality
left ovary	UBERON:0002119	49.29	gold quality
right uterine tube	UBERON:0001302	49.07	gold quality
mucosa of transverse colon	UBERON:0004991	49.03	gold quality
uterine cervix	UBERON:0000002	48.98	silver quality
ovary	UBERON:0000992	48.90	gold quality
esophagus mucosa	UBERON:0002469	48.82	gold quality
blood	UBERON:0000178	48.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Spdye4b	ENSMUSG00000029586
mus_musculus	Spdye4a	ENSMUSG00000039296
rattus_norvegicus	Spdye4	ENSRNOG00000058563

Paralogs (18): SPDYE1 (ENSG00000136206), SPDYE5 (ENSG00000170092), SPDYE2B (ENSG00000173678), SPDYE4 (ENSG00000183318), SPDYE12 (ENSG00000184616), SPDYE16 (ENSG00000185040), SPDYE2 (ENSG00000205238), SPDYE18 (ENSG00000205482), SPDYE3 (ENSG00000214300), SPDYE21 (ENSG00000230358), SPDYE6 (ENSG00000260097), SPDYE9 (ENSG00000262461), SPDYE8 (ENSG00000273520), SPDYE10 (ENSG00000274570), SPDYE11 (ENSG00000275976), SPDYE15 (ENSG00000286014), SPDYE13 (ENSG00000286038), SPDYE14 (ENSG00000286137)

Protein

Protein identifiers

Speedy protein E17 — P0DUD2 (reviewed: P0DUD2)

All UniProt accessions (1): P0DUD2

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the Speedy/Ringo family.

RefSeq proteins (1): NP_001338280* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR020984	Speedy	Family
IPR057742	Speedy_E	Family

Pfam: PF11357

UniProt features (3 total): chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DUD2-F1	70.85	0.43

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 2 (showing top): chr7q11, GOMF_KINASE_BINDING

GO Biological Process (1): positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)

GO Molecular Function (1): protein kinase binding (GO:0019901)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of cyclin-dependent protein serine/threonine kinase activity	1
cyclin-dependent protein serine/threonine kinase activity	1
positive regulation of cell cycle	1
positive regulation of protein serine/threonine kinase activity	1
positive regulation of cyclin-dependent protein kinase activity	1
kinase binding	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0J9YY54, A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NNV3, B4DH59, F6SZT2, P0C6Y7, P0CI01, P0DKJ7, P0DKJ8, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, P79386, Q08AG5, Q13342, Q16666, Q3BBV2, Q495Y8, Q587J8, Q5JRC9, Q5QGU6, Q5RD14, Q5RKG3, Q63HK3, Q6ITT4, Q7TQI8, Q86T75, Q8IWY8, Q8N660, Q8NFV5

Diamond homologs: A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NKU9, A6NLX3, A6NNV3, P0CI01, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, Q495Y7, Q495Y8, Q5IBH6, Q5IBH7, Q5MJ68, Q5MJ70, Q8NFV5, Q8R496, Q9PU13, Q9YGL1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1001582007 (7:77032568 T>C), RS1004375059 (7:77024244 C>T), RS1004872998 (7:77025706 T>C), RS1005470538 (7:77029118 C>G,T), RS1005791720 (7:77027470 A>G), RS1008769349 (7:77023774 C>G,T), RS1009258238 (7:77026281 G>A,C), RS1009318866 (7:77027235 G>C), RS1009639271 (7:77026571 C>A,T), RS1010674762 (7:77032634 A>G), RS1013027844 (7:77026114 G>T), RS1013314054 (7:77025766 A>G), RS1014079927 (7:77032422 TGG>T), RS1014732322 (7:77029474 C>G,T), RS1015469269 (7:77027757 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tobacco Smoke Pollution	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.