SPDYE18

Summary

SPDYE18 (speedy/RINGO cell cycle regulator family member E18, HGNC:51514) is a protein-coding gene on chromosome 7q11.23, encoding Speedy protein E18 (P0DV79).

Predicted to enable protein kinase binding activity.

Source: NCBI Gene 100505767 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001394953

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51514
Approved symbol	SPDYE18
Name	speedy/RINGO cell cycle regulator family member E18
Location	7q11.23
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000205482
Ensembl biotype	protein_coding
Entrez	100505767

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000510091, ENST00000965050

RefSeq mRNA: 2 — MANE Select: NM_001394953 NM_001351348, NM_001394953

CCDS: CCDS94131

Canonical transcript exons

ENST00000510091 — 9 exons

Exon	Start	End
ENSE00002019255	77059180	77059398
ENSE00002022364	77052733	77052837
ENSE00002030601	77057637	77057867
ENSE00002063887	77055236	77055321
ENSE00002069463	77056550	77056608
ENSE00003799859	77052960	77053203
ENSE00003919469	77060353	77060933
ENSE00003932588	77062496	77062558
ENSE00003935105	77050391	77051879

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 65.27.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
popliteal artery	UBERON:0002250	65.27	gold quality
tibial artery	UBERON:0007610	65.23	gold quality
left ovary	UBERON:0002119	64.81	gold quality
ovary	UBERON:0000992	64.36	gold quality
hindlimb stylopod muscle	UBERON:0004252	64.36	gold quality
mucosa of stomach	UBERON:0001199	64.16	gold quality
left testis	UBERON:0004533	64.04	gold quality
right lobe of thyroid gland	UBERON:0001119	64.03	gold quality
testis	UBERON:0000473	64.02	gold quality
skeletal muscle tissue	UBERON:0001134	63.99	gold quality
right ovary	UBERON:0002118	63.97	gold quality
right testis	UBERON:0004534	63.78	gold quality
thyroid gland	UBERON:0002046	63.04	gold quality
left lobe of thyroid gland	UBERON:0001120	62.92	gold quality
cerebellum	UBERON:0002037	62.42	gold quality
cerebellar cortex	UBERON:0002129	62.40	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.37	gold quality
cerebellar hemisphere	UBERON:0002245	62.33	gold quality
gastrocnemius	UBERON:0001388	62.27	gold quality
muscle of leg	UBERON:0001383	62.17	gold quality
muscle tissue	UBERON:0002385	61.62	gold quality
tibial nerve	UBERON:0001323	61.60	gold quality
right uterine tube	UBERON:0001302	61.29	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.27	gold quality
lower esophagus	UBERON:0013473	61.15	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.15	gold quality
duodenum	UBERON:0002114	61.10	gold quality
left coronary artery	UBERON:0001626	60.88	gold quality
subcutaneous adipose tissue	UBERON:0002190	60.78	gold quality
smooth muscle tissue	UBERON:0001135	60.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.85

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Spdye4b	ENSMUSG00000029586
mus_musculus	Spdye4a	ENSMUSG00000039296
rattus_norvegicus	Spdye4	ENSRNOG00000058563

Paralogs (18): SPDYE1 (ENSG00000136206), SPDYE5 (ENSG00000170092), SPDYE2B (ENSG00000173678), SPDYE4 (ENSG00000183318), SPDYE12 (ENSG00000184616), SPDYE16 (ENSG00000185040), SPDYE17 (ENSG00000186645), SPDYE2 (ENSG00000205238), SPDYE3 (ENSG00000214300), SPDYE21 (ENSG00000230358), SPDYE6 (ENSG00000260097), SPDYE9 (ENSG00000262461), SPDYE8 (ENSG00000273520), SPDYE10 (ENSG00000274570), SPDYE11 (ENSG00000275976), SPDYE15 (ENSG00000286014), SPDYE13 (ENSG00000286038), SPDYE14 (ENSG00000286137)

Protein

Protein identifiers

Speedy protein E18 — P0DV79 (reviewed: P0DV79)

All UniProt accessions (2): P0DV79, A0A8I5KS96

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the Speedy/Ringo family.

RefSeq proteins (2): NP_001338277, NP_001381882* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR020984	Speedy	Family
IPR057742	Speedy_E	Family

Pfam: PF11357

UniProt features (5 total): compositionally biased region 3, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DV79-F1	61.63	0.28

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 8 (showing top): chr7q11, GOMF_KINASE_BINDING, GSE14350_TREG_VS_TEFF_DN, GSE27786_LSK_VS_CD4_TCELL_DN, GSE3994_WT_VS_PAC1_KO_ACTIVATED_MAST_CELL_UP, GSE4142_NAIVE_VS_MEMORY_BCELL_UP, GSE6875_TCONV_VS_TREG_UP, GSE29164_DAY3_VS_DAY7_CD8_TCELL_TREATED_MELANOMA_DN

GO Biological Process (1): positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)

GO Molecular Function (1): protein kinase binding (GO:0019901)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of cyclin-dependent protein serine/threonine kinase activity	1
cyclin-dependent protein serine/threonine kinase activity	1
positive regulation of cell cycle	1
positive regulation of protein serine/threonine kinase activity	1
positive regulation of cyclin-dependent protein kinase activity	1
kinase binding	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0J9YX94, A0A0J9YXQ4, A0A0J9YY54, A0A494C1R9, A1L443, A5D7L8, A6NDY0, A6NKD2, E9PGG2, F6SZT2, O19110, O75807, O88852, P0CV98, P0CV99, P0CW00, P0CW01, P0CW24, P0DV79, P17564, P59644, P78358, Q01534, Q0P5N2, Q15735, Q2KI51, Q587J8, Q5R5G8, Q5R6R8, Q5RFC2, Q5SV97, Q60465, Q6P752, Q86V59, Q8BSI6, Q8N9W4, Q8NAG6, Q8NEE8, Q8VD63, Q95LS7

Diamond homologs: A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NKU9, A6NLX3, A6NNV3, P0CI01, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, Q495Y7, Q495Y8, Q5IBH6, Q5IBH7, Q5MJ68, Q5MJ70, Q8NFV5, Q8R496, Q9PU13, Q9YGL1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

2320 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000197874 (7:77053832 CTA>C), RS1000804650 (7:77058861 T>C), RS1001570351 (7:77060508 T>C), RS1002210621 (7:77060412 C>T), RS1002815715 (7:77062302 G>A), RS1003352887 (7:77053442 C>G), RS1003499751 (7:77050334 A>T), RS1003557118 (7:77064479 T>A), RS1003592166 (7:77052131 T>C), RS1004225007 (7:77063440 C>T), RS1004464341 (7:77057344 T>G), RS1004602031 (7:77058030 C>T), RS1005469758 (7:77059544 T>C), RS1005605655 (7:77060007 C>A,G,T), RS1006963683 (7:77061319 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
abrine	increases expression	1
Okadaic Acid	decreases expression	1
Lactic Acid	increases expression	1
Acrylamide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.